“…Researchers in studies of children and adults with a prior history of BPD have reported lower DL CO (25)(26)(27) than healthy controls; however, we are not aware of any previous study evaluating the DM and Vc in subjects with a history of BPD. Studies in adults with differing pulmonary diseases, including chronic obstructive pulmonary disease (28), pulmonary hypertension (29), and idiopathic interstitial pneumonia (30), have demonstrated reductions in both DM and Vc. However, DM/Vc ratios were increased in chronic obstructive pulmonary disease, reduced in pulmonary hypertension, and unchanged in idiopathic interstitial pneumonia, which may reflect the differing pathophysiology of these diseases.…”