Pulmonale und pleurale Manifestationen beim Plasmozytom

Schelle, M.; Schreiber, C.; Knolle, Juergen; Florschütz, Axel; Kachel, R; Schreiber, J

doi:10.1055/s-2006-944275

Cited by 8 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 In addition, only a few cases with histologically proven pulmonary involvement have been reported in the literature. [12][13][14][15][16][17][18] These findings suggest that the histological diagnosis of pulmonary involvement in myeloma is extremely difficult, particularly after bortezomib treatment, as in the present case. In patients with multiple myeloma who manifest abnormal pulmonary shadowing, pulmonary involvement from myeloma cells may be possible; therefore, lower doses of bortezomib should be initially administered to avoid severe DAH.…”

Section: Discussionsupporting

confidence: 51%

Early-Onset Severe Diffuse Alveolar Hemorrhage after Bortezomib Administration Suggestive of Pulmonary Involvement of Myeloma Cells

Sugita

Ohwada

Nagao

et al. 2015

J Clin Exp Hematopathol

View full text Add to dashboard Cite

Severe acute lung injury is a rare but life-threatening complication associated with bortezomib. We report a patient with multiple myeloma who developed a severe diffuse alveolar hemorrhage (DAH) immediately after the first bortezomib administration. The patient was suspected to have pulmonary involvement of myeloma, which caused DAH after rapidly eradicating myeloma cells in the lungs with bortezomib. Rechallenge with bortezomib was performed without recurrent DAH. In patients with multiple myeloma who manifest abnormal pulmonary shadow, we should be aware of early-onset severe DAH after bortezomib administration, which might be due to pulmonary involvement of myeloma cells.

show abstract

Section: Discussionsupporting

confidence: 51%

Early-Onset Severe Diffuse Alveolar Hemorrhage after Bortezomib Administration Suggestive of Pulmonary Involvement of Myeloma Cells

Sugita

Ohwada

Nagao

et al. 2015

J Clin Exp Hematopathol

View full text Add to dashboard Cite

show abstract

“…They may also report symptoms due to the infiltration of the surrounding organs. 5,6 Our patient complained of dyspnea on exertion associated with an important deterioration of her general status.…”

Section: Discussionmentioning

confidence: 81%

Case Report: A very rare case of a pleural effusion revealing multiple myeloma

Daboussi,

Saidane,

Mhamdi

et al. 2023

F1000Res

View full text Add to dashboard Cite

Multiple myeloma is a common malignant bone-based disease. Pleural effusions reported in these patients remain rare. It is commonly due to congestive heart disease, pulmonary embolism, nephrotic syndrome or a second neoplasia. The true myelomatous pleural effusion resulting from a direct tumoral invasion of the pleural are extremely rare. We report here the case of a massive pleural effusion revealing multiple myeloma in a 71-year-old patient. The chest ultrasound showed a massive pleural effusion in the left side with a multinodular thickening of the pleura. The medical thoracoscopy showed a grape-cluster appearance. The diagnosis was made by pleural guided biopsy revealing abnormal plasma cells with an intense positive CD 138 (plasma cell marker) and MUM1 (multiple myeloma oncogene1) staining with a light kappa chain in the protein electrophoresis associated with a myeloma. Unfortunately, our patient died one month after the initial diagnosis. We present also a review of the recent literature in order to highlight the clinical presentations of the myelomatous pleural effusion, the diagnostic tools, the therapeutic strategies as well as the outcomes.

show abstract

“…The immunodeficiency manifests as recurrent infections. In late stages the extramedullary plasma cell infiltration of other organs is possible but rare, 22 either in the form of bulky lesions or diffuse infiltration. The evolution of bulky plasma cell infiltration in bones is also possible but mainly occurs in the late stages of MM.…”

Section: Discussionmentioning

confidence: 99%

Unusual manifestation of a multiple myeloma in the hyoid bone

Sychra¹,

Eßer²,

Kosmehl³

et al. 2013

Dentomaxillofacial Radiology

View full text Add to dashboard Cite

The most common manifestation of plasma cell neoplasms is multiple myeloma. Solitary and localized tumours in the form of solitary plasmacytoma of the bone or extramedullary plasmacytoma are rare. In the late stages of multiple myeloma, bulky bone tumour infiltrates may be found which may be the primary clinical manifestation of the previously unknown malignancy. We report a case of a hyoid bone tumour with extramedullary plasma cell infiltrates in the oropharynx in multiple myeloma.

show abstract

Pulmonale und pleurale Manifestationen beim Plasmozytom

Cited by 8 publications

References 4 publications

Early-Onset Severe Diffuse Alveolar Hemorrhage after Bortezomib Administration Suggestive of Pulmonary Involvement of Myeloma Cells

Early-Onset Severe Diffuse Alveolar Hemorrhage after Bortezomib Administration Suggestive of Pulmonary Involvement of Myeloma Cells

Case Report: A very rare case of a pleural effusion revealing multiple myeloma

Unusual manifestation of a multiple myeloma in the hyoid bone

Contact Info

Product

Resources

About