Pullulan-stabilized gold nanoparticles tablet as a nanozyme sensor for point-of-care applications

Al-Kassawneh, Muna; Sadiq, Zubi; Jahanshahi‐Anbuhi, Sana

doi:10.1016/j.sbsr.2022.100526

Cited by 9 publications

(4 citation statements)

References 63 publications

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“…A tablet incorporating gold nanoparticles (AuNPs) was designed by encapsulating AuNPs within dextran matrices . This design ensures resilience to alkaline conditions while exhibiting heightened responsiveness in acidic environments due to nanogold aggregation within the lower pH range.…”

Section: Role Of Nanocarriers In Tabletized Nanomedicinementioning

confidence: 99%

“…Along the same lines, AuNPs encapsulated with a pullulan matrix tablet have been generated. The peroxidase catalytic activity of these AuNPs-pullulan tables is showcased through the oxidation of the substrate . These AuNPs-based tablets provide sensor activity in measuring the levels of glucose and hydrogen peroxide.…”

Section: Role Of Nanocarriers In Tabletized Nanomedicinementioning

confidence: 99%

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Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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The limitations of conventional therapeutic treatments prevailed in the development of nanotechnology-based medical formulations, termed nanomedicine. Nanomedicine is an advanced medicine that often consists of therapeutic agent(s) embedded in biodegradable or biocompatible nanomaterial-based formulations. Among nanomedicine approaches, tablet (oral) nanomedicine is still under development. In tabletized nanomedicine, the dynamic interplay between nanoformulations and the intricate milieu of the gastrointestinal tract simulates a pivotal role, particularly accentuating the influence exerted upon the luminal, mucosal, and epithelial cells. In this work, we document the perspectives and opportunities of nanoformulations toward the development of tabletized nanomedicine. This review also unveils the notion of integrating nanomedicine within a tablet formulation, which facilitates the controlled release of drugs, biomolecules, and agent(s) from the formulation to achieve a better therapeutic response. Finally, an attempt was made to explore current trends in nanomedicine technology such as bacteriophage, probiotic, and oligonucleotide tabletized nanomedicine and the combination of nanomedicine with imaging agents, i.e., nanotheranostics.

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Section: Role Of Nanocarriers In Tabletized Nanomedicinementioning

confidence: 99%

Section: Role Of Nanocarriers In Tabletized Nanomedicinementioning

confidence: 99%

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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“…17 In recent studies, the incorporation of reagent encapsulation techniques has been preferred to ensure swift detection in a liquid phase by discharging enclosed reagents during the testing process. 18–21 This combined method not only yields a sensitive detection system but also merges the beneficial aspects of point-of-care analytical devices. Therefore, scientists and researchers are keen to investigate novel platforms for point-of-care devices.…”

Section: Introductionmentioning

confidence: 99%

User-friendly and ultra-stable all-inclusive gold tablets for cysteamine detection

2023

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“…The encapsulation of the bioreagents in polysaccharides enhances the stability of enzymes in different external conditions, while the solid tablets act as a portable easy-to-use detection platform that can be inserted into the sample medium and readily dissolve to initiate the assay procedure. This approach has been successfully applied to a variety of assays, including the detection of phosphate in water [ 28 ] using AuNPs and nanozyme sensors for glucose detection in saliva with pullulan-stabilized AuNP tablets [ 29 ]. Among the various materials that have been explored for enzyme encapsulation, dextran has emerged as a promising candidate.…”

Section: Introductionmentioning

confidence: 99%

Tablet-Based Sensor: A Stable and User-Friendly Tool for Point-of-Care Detection of Glucose in Urine

Hajimiri,

Safiabadi Tali,

Al-Kassawneh

et al. 2023

Biosensors

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The colorimetric detection of glucose in urine through enzymatic reactions offers a low-cost and non-invasive method to aid in diabetes management. Nonetheless, the vulnerability of enzymes to environmental conditions, particularly elevated temperatures, and their activity loss pose significant challenges for transportation and storage. In this work, we developed a stable and portable tablet sensor as a user-friendly platform for glucose monitoring. This innovative device encapsulates glucose oxidase and horseradish peroxidase enzymes with dextran, transforming them into solid tablets and ensuring enhanced stability and practicality. The enzymatic tablet-based sensor detected glucose in urine samples within 5 min, using 3,3′,5,5′-tetramethylbenzidine (TMB) as the indicator. The tablet sensor exhibited responsive performance within the clinically relevant range of 0–6 mM glucose, with a limit of detection of 0.013 mM. Furthermore, the tablets detected glucose in spiked real human urine samples, without pre-processing, with high precision. Additionally, with regard to thermal stability, the enzyme tablets better maintained their activity at an elevated temperature as high as 60 °C compared to the solution-phase enzymes, demonstrating the enhanced stability of the enzymes under harsh conditions. The availability of these stable and portable tablet sensors will greatly ease the transportation and application of glucose sensors, enhancing the accessibility of glucose monitoring, particularly in resource-limited settings.

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Pullulan-stabilized gold nanoparticles tablet as a nanozyme sensor for point-of-care applications

Cited by 9 publications

References 63 publications

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

User-friendly and ultra-stable all-inclusive gold tablets for cysteamine detection

Tablet-Based Sensor: A Stable and User-Friendly Tool for Point-of-Care Detection of Glucose in Urine

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