Pullulan hydrogels as drug release platforms in biomedicine

Teixeira, Marta O.; Marinho, Elina; Silva, Carla; Antunes, Joana C.; Felgueiras, Helena P.

doi:10.1016/j.jddst.2023.105066

Cited by 10 publications

(4 citation statements)

References 154 publications

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“…Pullulan, a polysaccharide consisting of maltotriose units connected by α-1,4 glycosidic bonds, is biocompatible, non-toxic, non-mutagenic, non-immunogenic, and biodegradable [70]. Pullulan-based hydrogels sustain the bioactivity in drug delivery, offering adjustable release profiles [70]. In tissue engineering, the focus lies on multifunctional pullulan-based 3D scaffolds for efficient tissue regeneration [71].…”

Section: Polysaccharide-based Polymersmentioning

confidence: 99%

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Rana,

De la Hoz Siegler

2024

Gels

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Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, and structural similarity to the extracellular matrix. Recent chemical advancements have bolstered their versatility, facilitating the integration of the molecules guiding cellular activities and enabling their controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity and network imperfections, which adversely affect their mechanical properties, diffusion rates, and biological activity. In response to these challenges, hybrid hydrogels have emerged, aiming to enhance their strength, drug release efficiency, and therapeutic effectiveness. These hybrid hydrogels, featuring improved formulations, are tailored for controlled drug release and tissue regeneration across both soft and hard tissues. The scientific community has increasingly recognized the versatile characteristics of hybrid hydrogels, particularly in the biomedical sector. This comprehensive review delves into recent advancements in hybrid hydrogel systems, covering the diverse types, modification strategies, and the integration of nano/microstructures. The discussion includes innovative fabrication techniques such as click reactions, 3D printing, and photopatterning alongside the elucidation of the release mechanisms of bioactive molecules. By addressing challenges, the review underscores diverse biomedical applications and envisages a promising future for hybrid hydrogels across various domains in the biomedical field.

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Section: Polysaccharide-based Polymersmentioning

confidence: 99%

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Rana,

De la Hoz Siegler

2024

Gels

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“…In accordance with the type of material, it is possible to distinguish between three different kinds of hydrogels: natural hydrogels, which come from biological sources, such as proteins, polysaccharides, or nucleic acids; synthetic hydrogels, which are made from synthetic monomers; and hybrid hydrogels, which are made of both natural and synthetic materials [16,17]. Natural polymer-based hydrogels are made of polymers derived from alginate [18], pectin [19], carrageenan [20], chitosan [21], polylysine [22], collagen [18], carboxymethyl chitin [23], carboxymethylcellulose [24], dextran [25], agarose [26], and pullulan [27], among other matrices [28][29][30]. Synthetic polymer-based hydrogels include polyvinyl alcohol [31], polyethylene glycol [32], and polyacrylic acid [33], among others.…”

Section: Hydrogel Classificationmentioning

confidence: 99%

An Overview of Polymeric Hydrogel Applications for Sustainable Agriculture

Vedovello,

Sanches,

da Silva Teodoro

et al. 2024

Agriculture

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Agriculture, a vital element of human survival, confronts challenges of meeting rising demand due to population growth and product availability in developing nations. Reliance on pesticides and fertilizers strains natural resources, leading to soil degradation and water scarcity. Addressing these issues necessitates enhancing water efficiency in agriculture. Polymeric hydrogels, with their unique water retention and nutrient-release capabilities, offer promising solutions. These superabsorbent materials form three-dimensional networks retaining substantial amounts of water. Their physicochemical properties suit various applications, including agriculture. Production involves methods like bulk, solution, and suspension polymerization, with cross-linking, essential for hydrogels, achieved through physical or chemical means, each with different advantages. Grafting techniques incorporate functional groups into matrices, while radiation synthesis offers purity and reduced toxicity. Hydrogels provide versatile solutions to tackle water scarcity and soil degradation in agriculture. Recent research explores hydrogel formulations for optimal agricultural performance, enhancing soil water retention and plant growth. This review aims to offer a comprehensive overview of hydrogel technologies as adaptable solutions addressing water scarcity and soil degradation challenges in agriculture, with ongoing research refining hydrogel formulations for optimal agricultural use.

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“…1 Additionally, they are three-dimensional crosslinked polymeric networks that have the ability to swell in aqueous solution, but not to dissolve. 2,3 They are extensively investigated for a plethora of reasons, covering many research areas, such as drug delivery excipients, 4 bioprinting, 5 biomedicine, 6 and tissue engineering. 7 Furthermore, the hydrogels can be designed to have the desired physical/chemical characteristics, such as their mechanical strength and their potential to load and release drug molecules, which further expand their possible application in controlled drug delivery.…”

Section: Introductionmentioning

confidence: 99%