Pullulan-Functionalized Fe₃O₄ Nanoparticles with Mesopore Silica-Loaded Tetraphenylporphyrin Tetrasulfonic Acid Hydrate for Targeting Photodynamic Therapy

Recent Advances in Porphyrin-Based Inorganic Nanoparticles for Cancer Treatment

“…PL binds to the asialoglycoprotein receptor [109] which is overexpressed on HepG2 cells with maximum receptor activity [110]. The cellular uptake results from this study showed that the NPs internalized far better in HepG2 cells than Hela cells, due to the high asialoglycoprotein receptor overexpression in HepG2 cells, confirming the effective targeting ability of this nanocomposite [107]. Within PDT in vitro experiments with 200 µg mL −1 Fe 3 O 4 @mSiO 2 (TPPS)-PL NPs caused 65% loss of cell viability in HepG2 cells, while 100 g mL −1 of the nanocomposite noted only 20% of cells remained viable, after 20 min of treatment, suggesting the overall efficacy of this treatment for human hepatoma carcinoma [107].…”

“…A multifunctional nanosystem known as Fe 3 O 4 @mSiO 2 (TPPS)-PL was fabricated by Liu et al (2017) for the in vitro PDT treatment of HepG2 and HeLa cells [107]. The Fe 3 O 4 magnetic NPs were further coated with mesoporous silica and Pullulan (PL) targeting moieties were covalently attached onto the Fe 3 O 4 @mSiO 2 .…”

“…The Fe 3 O 4 magnetic NPs were further coated with mesoporous silica and Pullulan (PL) targeting moieties were covalently attached onto the Fe 3 O 4 @mSiO 2 . Tetraphenylporphyrin tetrasulfonic acid hydrate (TPPS) was then loaded into the silica shell of the nanocomposite to form Fe 3 O 4 @mSiO 2 (TPPS)-PL NPs [107]. PL is a water-soluble, nonionic polysaccharide [108] which has a low toxicity and immunogenicity [107].…”

“…Tetraphenylporphyrin tetrasulfonic acid hydrate (TPPS) was then loaded into the silica shell of the nanocomposite to form Fe 3 O 4 @mSiO 2 (TPPS)-PL NPs [107]. PL is a water-soluble, nonionic polysaccharide [108] which has a low toxicity and immunogenicity [107]. PL binds to the asialoglycoprotein receptor [109] which is overexpressed on HepG2 cells with maximum receptor activity [110].…”

Inorganic Nanoparticles for Cancer Treatment

“…A multifunctional nanosystem known as Fe O @mSiO (TPPS)-PL was fabricated by Liu et al (2017) for the in vitro Various studies have noted that metal and nitrogen co-doped carbon nanospheres could produce porphyrin-like metal coordination centers, with the ability to change redox states and electronic structures to form active sites . In this regard, synthesized gadolinium encapsulated graphene CNPs (Gd@GCNs) .…”