Pullulan film incorporated with nanocapsules improves pomegranate seed oil anti-inflammatory and antioxidant effects in the treatment of atopic dermatitis in mice

Cervi, Verônica Ferrari; Saccol, Camila Parcianello; Sari, Marcel Henrique Marcondes; Martins, Charles Ferreira; Rosa, Lucas Saldanha da; Ilha, Bruna Dias; Soares, Fábio Zovico Maxnuck; Luchese, Cristiane; Wilhelm, Ethel A.; Cruz, Letícia

doi:10.1016/j.ijpharm.2021.121144

Cited by 20 publications

(20 citation statements)

References 69 publications

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“…The HET-CAM alternative method was validated for eye irritation tests because of its high sensitivity [ 44 ]. However, it can be applied to prevent irritation in other mucous membranes, such as the skin [ 40 , 45 ]. In this study, the free or nanoencapsulated sesamol forms did not show any irritant effect, suggesting that the developed formulations are safe for the cutaneous application.…”

Section: Discussionmentioning

confidence: 99%

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

et al. 2023

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Irritant contact dermatitis is usually treated with corticosteroids, which cause expressive adverse effects. Sesamol is a phenolic compound with anti-inflammatory and antioxidant properties. This study was designed to evaluate a hydrogel containing sesamol-loaded ethylcellulose nanocapsules for the treatment of irritant contact dermatitis. The nanocapsules presented a size in the nanometric range, a negative zeta potential, a sesamol content close to the theoretical value (1 mg/mL), and a 65% encapsulation efficiency. Nanoencapsulation protected sesamol against UVC-induced degradation and increased the scavenging activity assessed by ABTS and DPPH radicals. The hydrogels were prepared by thickening the nanocapsule suspensions with guar gum (2.5%). The hydrogels maintained the nanometric size of the nanocapsules and a sesamol content of approximately 1 mg/g. The HET-CAM assay classified the hydrogels as nonirritating. The in vitro release of the hydrogel containing sesamol in the nanoencapsulated form demonstrated an initial burst effect followed by a prolonged sesamol release and a lower skin permeation in comparison with the hydrogel containing free sesamol. In addition, it exhibited the best anti-inflammatory effect in the irritant contact dermatitis model induced by croton oil, reducing ear edema and inflammatory cells infiltration, similar to dexamethasone (positive control). Therefore, the hydrogel containing sesamol in the nanoencapsulated form seemed to have a therapeutic potential in treating irritant contact dermatitis.

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Section: Discussionmentioning

confidence: 99%

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

et al. 2023

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“…Research has also shown that pomegranate extract reduces the generation of pro-inflammatory cytokines in skin cells and improves the functioning of the skin barrier. This is especially advantageous for those with atopic dermatitis, a disorder characterized by impaired skin barrier function [ 163 , 164 ]. The studies suggest that polyphenols hold promise for treating atopic dermatitis.…”

Section: Polyphenols and Their Significance In Skin Disease Therapymentioning

confidence: 99%

The Promising Role of Polyphenols in Skin Disorders

Farhan

2024

Molecules

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The biochemical characteristics of polyphenols contribute to their numerous advantageous impacts on human health. The existing research suggests that plant phenolics, whether consumed orally or applied directly to the skin, can be beneficial in alleviating symptoms and avoiding the development of many skin disorders. Phenolic compounds, which are both harmless and naturally present, exhibit significant potential in terms of counteracting the effects of skin damage, aging, diseases, wounds, and burns. Moreover, polyphenols play a preventive role and possess the ability to delay the progression of several skin disorders, ranging from small and discomforting to severe and potentially life-threatening ones. This article provides a concise overview of recent research on the potential therapeutic application of polyphenols for skin conditions. It specifically highlights studies that have investigated clinical trials and the use of polyphenol-based nanoformulations for the treatment of different skin ailments.

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“…As shown in Figure 1, there are three forms of EO in plants [18] (pp. 25,26,[39][40][41], including:…”

Section: Drug Delivery System and Plant-like Structure In Relation To...mentioning

confidence: 99%

Stabilization of Essential Oil: Polysaccharide-Based Drug Delivery System with Plant-like Structure Based on Biomimetic Concept

Lim

Yin

et al. 2023

Polymers

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Essential oils (EOs) have stability problems, including volatility, oxidation, photosensitivity, heat sensitivity, humidity sensitivity, pH sensitivity, and ion sensitivity. A drug delivery system is an effective way to stabilize EOs, especially due to the protective effect of polymeric drug carriers. Polysaccharides are frequently employed as drug carrier materials because they are highly safe, come in a variety of forms, and have plentiful sources. Interestingly, the EO drug delivery system is based on the biomimetic concept since it corresponds to the structure of plant tissue. In this paper, we associate the biomimetic plant-like structures of the EO drug delivery system with the natural forms of EO in plant tissues, and summarize the characteristics of polysaccharide-based drug carriers for EO protection. Thus, we highlight the research progress on polysaccharides and their modified materials, including gum arabic, starch, cellulose, chitosan, sodium alginate, pectin, and pullulan, and their use as biomimetic drug carriers for EO preparations due to their abilities and potential for EO protection.

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Pullulan film incorporated with nanocapsules improves pomegranate seed oil anti-inflammatory and antioxidant effects in the treatment of atopic dermatitis in mice

Cited by 20 publications

References 69 publications

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

The Promising Role of Polyphenols in Skin Disorders

Stabilization of Essential Oil: Polysaccharide-Based Drug Delivery System with Plant-like Structure Based on Biomimetic Concept

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