Puk16 Global Economic Evaluations of Dialysis Treatment Modalities

Just, PM; Riella, MC; Tschosik, EA; Noe, LL; Charro, FT de; Bhattacharyya, Sudipta

doi:10.1016/s1098-3015(10)65147-9

Value in Health

2007

DOI: 10.1016/s1098-3015(10)65147-9

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Puk16 Global Economic Evaluations of Dialysis Treatment Modalities

PM Just¹,

MC Riella²,

EA Tschosik³

et al.

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2014

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Drugs to Foster Kidney Regeneration in Experimental Animals and Humans

Gagliardini

Benigni

2014

Nephron Exp Nephrol

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Background: The incidence of kidney diseases is increasing worldwide and they are emerging as a major public health problem. Once mostly considered inexorable, renal disease progression can now be halted and lesions can even regress with drugs such as angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II type I receptor blockers, indicating the possibility of kidney repair. Summary: The discovery of renal progenitor cells lining the Bowman capsule of adult rat and human kidneys has shed light on the mechanism of repair by ACEi. Parietal progenitors are a reservoir of cells that contribute to podocyte turnover in physiological conditions. In the early phases of renal disease these progenitors migrate chaotically and subsequently proliferate, accumulating in Bowman's space. The abnormal behavior of parietal progenitors is sustained by the activation of CXCR4 receptors in response to an increased production of the chemokine SDF-1 by podocytes activated by the inflammatory environment. Ang II, via the AT₁ receptor, also contributes to progenitor cell proliferation. The CXCR4/SDF-1 and Ang II/AT₁ receptor pathogenic pathways both pave the way for lesion formation and subsequent sclerosis. ACEi normalize the CXCR4 and AT₁ receptor expression on progenitors, limiting their proliferation, concomitant with the regression of hyperplastic lesions in animals, and in a patient with crescentic glomerulopathy. Key Message: Understanding the molecular and cellular determinants of regeneration triggered by renoprotective drugs will reveal novel pathways that might be challenged or targeted by pharmacological therapy.

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Drugs to Foster Kidney Regeneration in Experimental Animals and Humans

Gagliardini

Benigni

2014

Nephron Exp Nephrol

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Quality of life data from EQ-5D for evidence-based health service practice in dialysis care

Eichler

Hess

Früh

et al. 2014

BMC Health Serv Res

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Puk16 Global Economic Evaluations of Dialysis Treatment Modalities

Cited by 2 publications

References 0 publications

Drugs to Foster Kidney Regeneration in Experimental Animals and Humans

Drugs to Foster Kidney Regeneration in Experimental Animals and Humans

Quality of life data from EQ-5D for evidence-based health service practice in dialysis care

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