PUK1 Diuretic Activity of Aqueous Extract of Boswellia Serrata Roxb. Oleo Gum in Normal Albino Rats

Asif, Muhammad; Atif, Muhammad; Sulaiman, Siti Noraini; Hassali, M.A.; Shafie, A.A.; Haq, N.; Saleem, Fahad

doi:10.1016/j.jval.2012.08.246

Cited by 10 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immediately after administration, the animals were placed in metabolic cages (one animal per cage), specially designed to separate urine and feces, and cumulative urine output at 1, 2, 4, and 6 h was recorded. The diuretic activity was expressed in mL/100 g body weight (Asif et al., 2014 ), while the diuretic index was calculated as the ratio between the diuresis of the animals treated with the test substance and the diuresis of the control group (Danamma et al., 2011 ).…”

Section: Methodsmentioning

confidence: 99%

Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy

et al. 2018

View full text Add to dashboard Cite

The hydrochlorothiazide (HCT) low solubility and permeability give rise to limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations; its low dose makes the achievement of a homogeneous drug distribution very difficult. Thus, the aim of this study was to investigate the effectiveness of a strategy based on the development of nanostructured lipid carriers (NLC) as an innovative oral pediatric formulation of HCT with improved therapeutic efficacy. The performance of various synthetic and natural liquid lipids was examined and two different preparation methods were employed, i.e. homogenization-ultrasonication (HU) and microemulsion (ME), in order to evaluate their influence on the NLC properties in terms of size, polydispersity index, ζ-potential, entrapment efficiency, gastric stability, and drug release properties. Precirol®ATO5 was used as solid lipid and Tween®80 and Pluronic®F68 as surfactants, formerly selected in a previous study focused on the development of HCT-solid lipid nanoparticles (SLNs). The presence of Pluronic®F68 did not allow ME formation. On the contrary, using Tween®80, the ME method enabled a higher entrapment efficiency than the HU. Regardless of the preparation method, NLCs exhibited great entrapment efficiency values clearly higher than previous SLNs. Moreover, NLC-ME formulations provided a prolonged release, which lasted for 6 h. In particular, NLC-ME containing Tween®20 as Co-Surfactant showed the best performances, giving rise to a complete drug release, never achieved with previous SLN formulations, despite their successful results. In vivo studies on rats confirmed these results, displaying their best diuretic profile. Moreover, all HCT-loaded NLC formulations showed higher stability than the corresponding SLNs.

show abstract

Section: Methodsmentioning

confidence: 99%

Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy

et al. 2018

View full text Add to dashboard Cite

show abstract

“…biting and scratching behavior, licking of tail, paw and penis, intense grooming behavior and vocalization) and diarrhea [12,17]. Mortality of the animals was noted at end of 24 hours [12,13,17].…”

Section: Assessment Of Acute Toxicitymentioning

confidence: 99%

Diuretic Activity of <i>Achyranthes aspera</i> Linn Crude Aqueous Extract in Albino Rats

Asif¹,

Jabeen²,

Atif³

et al. 2015

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…The experimental protocols are: H: intact healthy group Gr1: induced burn without treatment Gr2: induced burn and treated with silver sulfadiazine Gr3: induced burn and treated with methanolic extract of B. serrata-dexrin-glycerin combination. The extraction process was first done on the Oleo gum resin using methanol by maceration (cold method), then the methanolic extract was mixed with dextrin and glycerin with continuous heating and stirring using magnetic stirrer and electric heater, the final combination was left to cool down (10) . At the end of the experiment the animals have been sacrificed by ether on day 29.…”

Section: Methodsmentioning

confidence: 99%

The Use of Methanolic Extract of Boswellia Serrata in Combination With Dextrin and Glycerin for Treatment of Experimentally Induced Thermal Injuries in Rabbits

2016

IJMS

View full text Add to dashboard Cite

Background Thermal injuries and burns are considered as the major health care problem worldwide. Burns in general are life-threatening condition with high morbidity and mortality. Wound infection and delayed wound healing are the main essential problems in burned patients and represent the major goals for new therapeutic strategies. Frankincense, the gum resin of the Boswellia serrata tree have traditionally been used in folk medicine for centuries to manage different chronic inflammatory diseases, the anti-inflammatory potential of lipophilic Boswellia serrata extracts were confirmed by experimental data from animal models and clinical studies on humans. Objective Comparing the wound healing effect of methanol extract of Boswellia serrata-dextrin-glycerin combination to that of silver sulfadiazine. Methods The dried powder of the oleo gum resin was extracted by cold method (maceration) using methanol and then the dried extract was mixed with dextrin and glycerin (30 gm, 40 ml, 60 gm) respectively. Thirty-two domestic male rabbits were divided into four groups, eight animals for each group, the groups were; intact healthy (H), burned without treatment (Gr1), burned and treated with silver sulfadiazine (Gr2) and burned and treated with the methanolic extract of Boswellia serrata-dextrin-glycerin combination (Gr3). Thermal injury was induced in all groups (except the intact healthy group) and treated topically on burned area once daily for 28 days. Tissue levels of vascular endothelial cell growth factor (VEGF) and tumor necrosis factor alpha (TNF-α) were assessed in addition to skin histological examination at the end of the study (day 29). Results Histopathological evaluation showed enhanced inflammatory response, granulation tissue formation, and collagen deposition due to the appropriate regulation of TNF-α and VEGF. Conclusion Topical use of the methanolic extract of Boswellia serrata-dextrin-glycerin combination significantly enhanced wound healing activities.

show abstract

PUK1 Diuretic Activity of Aqueous Extract of Boswellia Serrata Roxb. Oleo Gum in Normal Albino Rats

Cited by 10 publications

References 0 publications

Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy

Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy

Diuretic Activity of <i>Achyranthes aspera</i> Linn Crude Aqueous Extract in Albino Rats

The Use of Methanolic Extract of Boswellia Serrata in Combination With Dextrin and Glycerin for Treatment of Experimentally Induced Thermal Injuries in Rabbits

Contact Info

Product

Resources

About