PUFA in the pathogenesis and treatment of patients with multiple sclerosis

Harbige, Laurence S.; Pinto, E.; Xiang, M.; Leach, Michael J.; Sharief, Mohammed

doi:10.1017/s0029665108006307

Cited by 7 publications

(3 citation statements)

References 2 publications

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“…The authors reported that a dose of 5 g/day over 18 months produced no benefit whatsoever on any parameter of disease activity, surrogate or otherwise. A dose of 14 g/day on the other hand, over the same time period, significantly reduced the annualised mean of relapses per patient and the levels of disability as measured by EDSS scores [265].…”

Section: Lipid Rafts Mlrs and N-3 Pufas In Multiple Sclerosismentioning

confidence: 78%

The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders

Morris¹,

Walder

Puri

et al. 2015

Mol Neurobiol

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Oxidative and nitrosative stress (O&NS) is causatively implicated in the pathogenesis of Alzheimer's and Parkinson's disease, multiple sclerosis, chronic fatigue syndrome, schizophrenia and depression. Many of the consequences stemming from O&NS, including damage to proteins, lipids and DNA, are well known, whereas the effects of O&NS on lipoprotein-based cellular signalling involving palmitoylation and plasma membrane lipid rafts are less well documented. The aim of this narrative review is to discuss the mechanisms involved in lipid-based signalling, including palmitoylation, membrane/lipid raft (MLR) and n-3 polyunsaturated fatty acid (PUFA) functions, the effects of O&NS processes on these processes and their role in the abovementioned diseases. S-palmitoylation is a post-translational modification, which regulates protein trafficking and association with the plasma membrane, protein subcellular location and functions. Palmitoylation and MRLs play a key role in neuronal functions, including glutamatergic neurotransmission, and immune-inflammatory responses. Palmitoylation, MLRs and n-3 PUFAs are vulnerable to the corruptive effects of O&NS. Chronic O&NS inhibits palmitoylation and causes profound changes in lipid membrane composition, e.g. n-3 PUFA depletion, increased membrane permeability and reduced fluidity, which together lead to disorders in intracellular signal transduction, receptor dysfunction and increased neurotoxicity. Disruption of lipid-based signalling is a source of the neuroimmune disorders involved in the pathophysiology of the abovementioned diseases. n-3 PUFA supplementation is a rational therapeutic approach targeting disruptions in lipid-based signalling.

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Section: Lipid Rafts Mlrs and N-3 Pufas In Multiple Sclerosismentioning

confidence: 78%

The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders

Morris¹,

Walder

Puri

et al. 2015

Mol Neurobiol

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“…A linhaça é fonte dos ácidos graxos α-linolênico e linoléico, precursores do ω-3 e ω-6, respectivamente. Tais ácidos são importantes para o desenvolvimento do sistema nervoso central, auxiliam na prevenção de doenças cardiovasculares, diabetes e determinados tipos de câncer, atuam ainda na redução de processos inflamatórios e doenças auto--imunes 7 .…”

Section: N T R O D U ç ã Ounclassified

Avaliação dos efeitos da semente de linhaça quando utilizada como fonte de proteína nas fases de crescimento e manutenção em ratos

et al. 2009

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OBJETIVO: O objetivo deste trabalho foi avaliar a qualidade protéica da linhaça quando usada nas fases de crescimento e manutenção em ratos. MÉTODOS: Na primeira etapa utilizaram-se 18 Rattus norvegicus, Wistar, fêmeas, recém-desmamadas, recebendo água e ração à vontade. Estas foram distribuídas em 3 grupos (n=6): grupo linhaça - com dieta à base de linhaça, grupo controle - com dieta à base de caseína, grupo controle modificado - com dieta à base de caseína, com maior concentração de fibras e óleo. Na segunda etapa (após 28 dias de experimento) a dieta do grupo linhaça foi modificada, acrescentou-se 5,4% de caseína. Os demais grupos permaneceram com as mesmas dietas. Todas eram isoenergéticas e continham 10% de proteína. Os animais foram acompanhados até 180 dias de vida. Foram determinados o quociente de eficiência protéica e a albumina nas duas fases do experimento. RESULTADOS: Na primeira etapa, o grupo linhaça obteve quociente de eficiência protéica (0,8, DP=0,05) significantemente menor que o grupo controle (2,3, DP=0,1) e o controle modificado (2,3, DP=0,2). A concentração de albumina do grupo linhaça (3,0, DP=0,04g/dL) foi menor (p<0,01) que a do grupo controle (3,9, DP=0,06g/dL) e a do controle modificado (3,9, DP=0,01g/dL). Já na segunda etapa, o grupo linhaça modificado (1,2, DP=0,1) obteve maior (p<0,01) quociente de eficiência protéica que grupo controle (0,9, DP=0,02) e o controle modificado (0,9, DP=0,05). Não houve diferença significante no teor de albumina entre os grupos, caracterizando a recuperação da desnutrição. CONCLUSÃO: Conclui-se que a linhaça não deve ser utilizada como fonte exclusiva de proteína, principalmente na fase de crescimento.

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“…E-mail: pa.cremonez@gmail.com. (FAO, 2008;Oomah and Mazza, 1993;Westcott and Muir, 2003;Harbige et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Fertigation of stillage in the culture of brown and golden linseed (Linum usitatissimum)

Cremonez¹,

Feiden²,

Santos³

et al. 2014

Afr. J. Biotechnol.

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In Brazil, the stillage is mainly used in fertigation of sugarcane plantations, however, little is known about its effect on the nutritional supplementation and irrigation cultivation of linseed. Because of the shortage of work in the area, the present study aimed to evaluate the development of the culture of brown and golden linseed submitted to fertigation of stillage. The experiment was conducted in the field, at the Federal University of Paraná in Palotina/PR in the agricultural year of 2013, on a eutrophic Red Latosol. The adopted lineation was completely randomized in split plots, where the plots were composed by the two varieties (brown and gold), and the sub-plots by the ratios (100% stillage; 50% stillage and 50% water; 100% control water). Fertigation of stillage in the culture of brown and golden linseed presents positive results on plant height, dry and fresh weight, capsules number and productivity; except for the number of branches (100% is higher). It was observed that between the two varieties, the golden linseed showed better development with the applied treatment.

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PUFA in the pathogenesis and treatment of patients with multiple sclerosis

Cited by 7 publications

References 2 publications

The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders

The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders

Avaliação dos efeitos da semente de linhaça quando utilizada como fonte de proteína nas fases de crescimento e manutenção em ratos

Fertigation of stillage in the culture of brown and golden linseed (Linum usitatissimum)

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