Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats

Liang, Junbo; Chen, Haixiao; Pan, Weibo; Xu, Chunlan

doi:10.3892/mmr.2012.854

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…Studies with GLP-1 analogs among the animal models, in-vitro cell lines and human islet cells have shown a reduction in apoptosis, which was associated with a significant downregulation of caspase-3 and up-regulation of bcl-2, and an increase in intracellular insulin content [47,64,66,67]. In an earlier study, Puerarin, one of the components of PTY-2, decreased the expression of caspase-3 in osteoblasts of diabetic rats and improved the pathological changes in diabetic rats [68].…”

Section: Discussionmentioning

confidence: 94%

Anti-oxidant, anti-apoptotic, anti-hypoxic and anti-inflammatory conditions induced by PTY-2 against STZ-induced stress in islets

Srivastava

Pandey

Singh

et al. 2019

Preprint

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Background and Aim: Earlier assessment of Pueraria tuberosa tubers has shown anti-diabetic effects through incretin mimetic action and DPP-IV inhibition. The aim of this work was to further explore the protective role of aqueous extract of Pueraria tuberosa against streptozotocin (STZ)-induced pancreatic stress in rats. Methods:Diabetes was induced with STZ (65 mg/kg body weight) in Charles foster male rats. After 60 days of STZ administration, animals with blood glucose levels > 200 g/dL were considered as diabetic. All the rats were later divided into three groups: Group-1 (STZ untreated normal rats), Group-2 (Diabetic control), and Group-3 (PTY-2 [50 mg/100 g bw treatment for next 10 days to diabetic rats). The rats were then sacrificed at the 10 th day of treatment accordingly.

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Section: Discussionmentioning

confidence: 94%

Anti-oxidant, anti-apoptotic, anti-hypoxic and anti-inflammatory conditions induced by PTY-2 against STZ-induced stress in islets

Srivastava

Pandey

Singh

et al. 2019

Preprint

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“…Stimulation of new bone formation was also observed in a rat model of osteoblast implant [295]. In the streptozotocin-induced diabetic rat model, puerarin treatment suppressed the caspase-3 expression in osteoblasts and improved bone mineral density [296]. Puerarin prevented osteonecrosis induced by alcohol in mice as well as in cultured bone marrow stromal cells [297].…”

Section: Natural Products With Osteoprotective and Related Activitiesmentioning

confidence: 99%

Natural Products from Chinese Medicines with Potential Benefits to Bone Health

2016

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Abstract:Osteoporosis is a progressive, systemic bone disorder characterized by loss of bone mass and microstructure, leading to reduced bone strength and increased risk of fracture. It is often associated with reduced quality of life and other medical complications. The disease is common in the aging population, particularly among postmenopausal women and patients who receive long-term steroidal therapy. Given the rapid growth of the aging population, increasing life expectancy, the prevalence of bone loss, and financial burden to the healthcare system and individuals, demand for new therapeutic agents and nutritional supplements for the management and promotion of bone health is pressing. With the advent of global interest in complementary and alternative medicine and natural products, Chinese medicine serves as a viable source to offer benefits for the improvement and maintenance of bone health. This review summarizes the scientific information obtained from recent literatures on the chemical ingredients of Chinese medicinal plants that have been reported to possess osteoprotective and related properties in cell-based and/or animal models. Some of these natural products (or their derivatives) may become promising leads for development into dietary supplements or therapeutic drugs.

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“…[ 77 ], decreased expression of caspase-3 in osteoblasts (80 mg/kg/day for 6 weeks; i.p.) [ 30 ], and reduced blood glucose and improved empty lacunar and BMD (100 mg/kg for 6 weeks, i.p. [ 31 ]) in STZ (65 mg/kg) induced diabetic rats.…”

Section: Preclinical Advances Of Dop In Tcmmentioning

confidence: 99%

Diabetic Osteoporosis: A Review of Its Traditional Chinese Medicinal Use and Clinical and Preclinical Research

Zhu

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Aim. The incidence of diabetic osteoporosis (DOP) is increasing due to lack of effective management over the past few decades. This review aims to summarize traditional Chinese medicine (TCM) suitability in the pathogenesis and clinical and preclinical management of DOP. Methods. Literature sources used were from Medline (Pubmed), CNKI (China Knowledge Resource Integrated Database), and CSTJ (China Science and Technology Journal Database) online databases. For the consultation, keywords such as diabetic osteoporosis (DOP), TCM, clinical study, animal experiment, toxicity, and research progress were used in various combinations. Around 100 research papers and reviews were visited. Results. Liver-spleen-kidney insufficiency may result in development of DOP. 18 clinical trials are identified to use TCM compound prescriptions for management of patients with DOP. TCM herbs and their active ingredients are effective in preventing the development of DOP in streptozotocin (STZ) and alloxan as well as STZ combined with ovariectomy insulted rats. Among them, most frequently used TCM herbs in clinical trials are Radix Astragali, Radix et Rhizoma Salviae Miltiorrhizae, Radix Rehmanniae Preparata, and Herba Epimedii. Some of TCM herbs also exhibit toxicities in clinical and preclinical research. Conclusions. TCM herbs may act as the novel sources of anti-DOP drugs by improving bone and glucolipid metabolisms. However, the pathogenesis of DOP and the material base of TCM herbs still merit further study.

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Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats

Cited by 7 publications

References 27 publications

Anti-oxidant, anti-apoptotic, anti-hypoxic and anti-inflammatory conditions induced by PTY-2 against STZ-induced stress in islets

Anti-oxidant, anti-apoptotic, anti-hypoxic and anti-inflammatory conditions induced by PTY-2 against STZ-induced stress in islets

Natural Products from Chinese Medicines with Potential Benefits to Bone Health

Diabetic Osteoporosis: A Review of Its Traditional Chinese Medicinal Use and Clinical and Preclinical Research

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