Puerarin inhibited 3-chloropropane-1,2-diol fatty acid esters formation by reacting with glycidol and glycidyl esters

Effect of acrolein, a lipid oxidation product, on the formation of the heterocyclic aromatic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in model systems and roasted tilapia fish patties

“…Phenylalanine (0.2 mmol) or creatinine (0.2 mmol) was mixed with different amounts of acrolein (0, 0.02, 0.04, 0.08, 0.16, 0.2, 0.4 mmol) in 5 mL of distilled water in screw cap-sealed tubes. The mixture was heated at 130 °C for 2 h and further analyzed by semi-preparative HPLC system (Shimadzu) to identify reaction products (new peaks) formed in the model system ( Wang, Tao, Zhu, Fan, Wang, & Zhao, 2021 ). Briefly, separation was performed on a SunFire Prep C18 OBD column (5 μm, 250 mm × 19 mm) eluted with water (solvent A) and acetonitrile (solvent B) with a flow rate of 5 mL/min.…”

Bibliometric Analysis of Research Trends on 3-Monochloropropane-1,2-Diol Esters in Foods

“…97 Additionally, Wang et al found that puerarin can react with glycidol and glycidol esters to inhibit 3-MCPDE formation. 98 Recently, Zheng et al found phytosterols can inhibit the formation of 3-MCPDE in chemical reaction models, through scavenging free radical intermediates and competing for chloride ions with glyceride. 99 These findings suggest that certain chemicals can inhibit the formation of 3-MCPDE not only by scavenging free radicals but also by reacting with intermediates or precursors, opening a new field of research on 3-MCPDE mitigation.…”

“…Moreover, some antioxidants, such as oleoresin rosemary, BHA, TBHQ, BHT, and sage extract were effective in inhibiting the formation of 3-MCPDE during oil frying . Additionally, Wang et al found that puerarin can react with glycidol and glycidol esters to inhibit 3-MCPDE formation . Recently, Zheng et al found phytosterols can inhibit the formation of 3-MCPDE in chemical reaction models, through scavenging free radical intermediates and competing for chloride ions with glyceride .…”

Apigenin and its octoic acid diester attenuated glycidol-induced autophagic-dependent apoptosis via inhibiting the ERK/JNK/p38 signaling pathways in human umbilical vein endothelial cells (HUVECs)

“…Glycidol and its esters glycidyl esters (GEs) are well-known food contaminants mainly formed in refined edible oils and thermally processed foods containing salt and fat such as cooked/cured fish or meat, malt-derived products, and bakery products ( Jiang et al, 2021 ; Wang et al, 2021a , Wang et al, 2021b ), which implies their frequent exposure by the general public. The epoxide group of glycidol could react with DNA, proteins, and cellular glutathione under physiological systems, and induce many diseases such as kidney toxicity, cardiovascular diseases, and cancers ( Bakhiya et al, 2011 ; Yamada et al, 2010 ).…”

“…Endothelial cells are continuously exposed to and in constant contact with serum circulating substances, making them a target of glycidol ( Zhang et al, 2018 ). Since endothelial cells play a key role in regulating and maintaining vascular health, the dysfunction of endothelial cells has been considered as a key trigger of a number of cardiovascular diseases ( Cao et al, 2017 ; Endemann and Schiffrin, 2004 ; Little et al, 2021 ; Wang et al, 2021a , Wang et al, 2021b ). Therefore, it is of great significance to study the effect and related mechanism of glycidol on vascular endothelial cells so as to develop effective therapeutic strategies to protect Humans from the toxic effects of glycidol.…”