Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ–induced early diabetic rats

Abstract

Puerarin is able to enhance SOD activity, and inhibit RAGE and VEGF expressions in retinas of STZ-induced early diabetic rats.

Silybin reduces obliterated retinal capillaries in experimental diabetic retinopathy in rats

“…Previous studies have shown that a large number of flavonoids possess protective effects on diabetes-induced retinal pathological alterations, including vascular hyperpermeability, vascular endothelial cell injury, and excessive retinal proinflammatory cytokines (Chen et al, 2012;Chung et al, 2005;Kumar et al, 2013Kumar et al, , 2012Li et al, 2013;Nakajima et al, 2001;Yang et al, 2009). Present study was designed to explore the potential effect of silybin, also a kind of flavonoid compound, on retinal blood vessels in diabetes that was induced in rats with STZ plus high-fat diet.…”

Effects of delayed puerarin treatment in long-term neurological outcomes of focal ischemic stroke in rats

“…[13] Puerarin, a form of herbal medicine, which has shown that it attenuates brain damage after ischemic stroke in rats. [45814] Previous studies have demonstrated that puerarin has multiple therapeutic effects involving anti-apoptosis,[14] anti-inflammation[4] anti-oxidative stress,[1516] anti-excitotoxicity,[16] activated potassium channel[3] and increase cerebral blood flow,[17] indicating puerarin might be a novel candidate for new drug development. However, all these published studies focused only on pre-stroke or early puerain treatment in acute brain tissue damage.…”

Suppressive Effects of Puerariae Radix on the Breast Tumor Incidence in Rats Treated with DMBA

“…In the present study, PR significantly reduced the elevated levels of VEGF-C in DMBA rats, suggesting that it might inhibit breast tumor formation by downregulating vascular angiogenesis factors in rat DMBA-induced breast tumors. An association between puerarin and VEGF has been reported in several studies, and puerarin has been suggested to suppress the vascularization of ectopic endometrial tissues stimulated by 17β-estradiol (Wang et al, 2011) and to inhibit VEGF expression in retinas of streptozotocin-induced early diabetic rats (Chen et al, 2012a). Other reports suggest that puerarin may induce therapeutic angiogenesis by increasing VEGF mRNA expression in rats with myocardial infarction (Zhang et al, 2006).…”