Puerarin: A Review of Pharmacological Effects

Zhou, Yan-Xi; Zhang, Hong; Peng, Cheng

doi:10.1002/ptr.5083

Cited by 475 publications

(312 citation statements)

References 124 publications

(129 reference statements)

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“…The isoflavones 84-85 are abundant in legumes, soy and show potent estrogenic activity by interacting with the estrogenic receptors [76,77]. Puerarin (86) is the main active principle of Pueraria lobata root (Fabaceae) and it used in clinical practice in China to treat cardiovascular diseases, cerebrovascular disorders, Parkinson's disease, Alzheimer's disease, diabetes and diabetic complications [78]. The flavonols 89-91 were isolated from leaves of Quercus ilex (Fagaceae) and belong to the group of acylated flavonoids ( Figure 19).…”

Section: Although a Comparison Between Results Ofmentioning

confidence: 99%

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

2016

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Phenols are among the largest and most widely distributed groups of secondary metabolites within the plant kingdom. They are implicated in multiple and essential physiological functions. In humans they play an important role as microconstituents of the daily diet, their consumption being considered healthy. The physical and chemical properties of phenolic compounds make these molecules versatile ligands, capable of interacting with a wide range of targets, such as the Carbonic Anhydrases (CAs, EC 4.2.1.1). CAs reversibly catalyze the fundamental reaction of CO 2 hydration to bicarbonate and protons in all living organisms, being actively involved in the regulation of a plethora of patho/physiological processes. This review will discuss the most recent advances in the search of naturally occurring phenols and their synthetic derivatives that inhibit the CAs and their mechanisms of action at molecular level. Plant extracts or mixtures are not considered in the present review.

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Section: Although a Comparison Between Results Ofmentioning

confidence: 99%

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

2016

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“…Pharmacological uses of puerarin are considered to be wide, and it may be useful in the treatment of cardiovascular and cerebrovascular diseases with further development (9). Puerarin does not result in marked proliferation of rat osteoblasts, however, it promotes the synthesis and secretion of alkaline phosphatase from osteoblasts (10). Furthermore, it may reduce bone resorption lacunae (11).…”

Section: Introductionmentioning

confidence: 99%

Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling

Wang

Jin

et al. 2016

Molecular Medicine Reports

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Abstract. Puerarin is an important active ingredient in the root of kudzu vine due to its pharmacological properties. The aim of the present study is to contribute to the existing knowledge of the effect of puerarin in the attenuation of inflammation and oxidation in mice with collagen antibody-induced arthritis via toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling. Arthritis was induced using injection of anti-type II collagen antibodies. Treatment with puerarin was observed to significantly decrease clinical scoring of the collagen antibody-induced arthritis and suppress oxidative stress and the inflammatory response in mice. Furthermore, puerarin was demonstrated to inhibit mRNA expression of matrix metalloproteinase-9 and protein expression of TLR4 following collagen antibody-induced arthritis in mice. The effect of puerarin may be associated with the suppression of NF-κB activity in collagen antibody-induced arthritis mice. Furthermore, upregulation of phosphorylated (p)-Janus kinase 2 and p-signal transducer and activator of transcription 3 protein expression was suppressed by puerarin. The results of the present study indicate, for the first time, the effect of puerarin to attenuate inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling.

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“…The neuroprotective potential of puerarin has been comprehensively evaluated in cell cultures and rodent models of several neurodegenerative diseases (16). A previous study showed that puerarin suppressed 6-hydroxydopamine-induced nitric oxide (NO) production and neurotoxicity in PC12 cells and primary rat midbrain neurons, which was attributed to the activation of arginase-2 in the L-arginine-NO pathway (17).…”

Section: Discussionmentioning

confidence: 99%

Puerarin prevents tumor necrosis factor-α-induced apoptosis of PC12 cells via activation of the PI3K/Akt signaling pathway

Liang

Xie

2017

Experimental and Therapeutic Medicine

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Abstract. Tumor necrosis factor-α (TNF-α), a potential proinflammatory cytokine, is an important component involved in neuronal apoptosis associated with neuroinflammation in the central nervous system. It has been reported that puerarin possesses pharmacological effects, such as anti-apoptotic, antioxidant, anti-osteoporosis, anti-inflammatory, cardioprotective and neuroprotective actions. The aim of the present study was to explore the effect of puerarin on apoptosis induced by TNF-α (3x10 5 U/l) and its detailed mechanisms in PC12 cells. MTT and flow cytometric assays were performed to evaluate cell cytotoxicity and apoptosis, respectively. An enzymatic assay was used to detect the activity of caspase-3 and caspase-9. Western blot analysis was performed to assess changes in the levels of proteins, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), caspase-3, Akt and phosphorylated Akt. The results showed that puerarin (25 and 50 µM) significantly suppressed TNF-α-induced apoptosis in PC12 cells. The TNF-α-induced in crease in the Bax/Bcl-2 ratio was markedly inhibited by pre-treatment with puerarin for 2 h. In addition, puerarin decreased the level of TNF-α-induced cleaved caspase-3. Furthermore, puerarin inhibited the TNF-α-induced decrease in the phosphorylation of Akt, which was abolished by LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, suggesting that the PI3K/Akt pathway participated in the suppressive effect of puerarin. Taken together, these findings indicated that puerarin prevented TNF-α-induced apoptosis in PC12 cells via activating of the PI3K/Akt signaling pathway, suggesting that puerarin may be a potential neuroprotective drug in the clinical treatment of neuroinflammation via anti-apoptotic mechanisms.

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Puerarin: A Review of Pharmacological Effects

Cited by 475 publications

References 124 publications

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling

Puerarin prevents tumor necrosis factor-α-induced apoptosis of PC12 cells via activation of the PI3K/Akt signaling pathway

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