Puerarin: A review of its mechanisms of action and clinical studies in ophthalmology

Meng, Fan Yun; Guo, Boling; Ma, Yi-qing; Li, Kunwei; Niu, Fengju

doi:10.1016/j.phymed.2022.154465

Cited by 22 publications

(5 citation statements)

References 102 publications

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“…This test confirmed that the hydrogel has the ability to self‐heal and restore the broken structure, [ 29 ] which prevents the hydrogel from degrading into gel fragments under external pressure, thus maintaining the protective effect on the wound and further extending the service life of the hydrogel. [ 30 ] The viscosity of the hydrogel decreased with increasing shear rate, indicating the existence of shear‐thinning properties and the injectable potential of the hydrogel. This is mainly attributed to the dynamic network structure because of the noncovalent interactions in the supramolecular hydrogel (Figure 3g).…”

Section: Resultsmentioning

confidence: 99%

Dual Self‐Assembly of Puerarin and Silk Fibroin into Supramolecular Nanofibrillar Hydrogel for Infected Wound Treatment

Yang,

Zhao,

Zhang

et al. 2024

Adv Healthcare Materials

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The treatment of infected wounds remains a challenging biomedical problem because of the complex microenvironment at the wound bed. Some natural bioactive small‐molecule hydrogelators with unique rigid structures can self‐assemble into supramolecular hydrogels, serving as supporting dressings and therapeutic agents for wound healing. However, they are still suffered from low structural stability and bio‐functionality. Herein, we proposed a supramolecular hydrogel antibacterial dressing with a dual nanofibrillar network structure. A nanofibrillar network created by small‐molecule hydrogelator, puerarin extracted from the traditional Chinese medicine Pueraria, was interconnected with a secondary macromolecular silk fibroin nanofibrillar network induced by Ga ions via charge‐induced supramolecular self‐assembly. The resulting hydrogel features adequate mechanical strength for sustainable retention at wounds. The good biocompatibility and efficient bacterial inhibition were also obtained when the Ga ion concentration was 0.05%. Otherwise, the substantial release of Ga ions and puerarin endows the hydrogel with excellent hemostatic and antioxidative properties. In vivo evaluation on a mouse infected wound model demonstrates that its healing effect outperformed that of a commercially available silver‐containing wound dressing. The experimental group successfully achieved a 100% wound closure rate on day 10 of treatment. This study sheds a new light on the design of nanofibrillar hydrogels based on supramolecular self‐assembly of naturally derived bioactive and/or biofunctional molecules as well as their clinical use for the treatment of chronic infected wounds.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Dual Self‐Assembly of Puerarin and Silk Fibroin into Supramolecular Nanofibrillar Hydrogel for Infected Wound Treatment

Yang,

Zhao,

Zhang

et al. 2024

Adv Healthcare Materials

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“…As a traditional Chinese medicine, the pharmacological effects of puerarin have been widely reported, including clinical applications (18)(19)(20). It has been reported that puerarin can alleviate osteoporosis in OVX-induced mice by inhibiting osteoclast generation by inhibiting the TRAF6/ROS-dependent MAPK/NF-κB signaling pathway (21).…”

Section: Discussionmentioning

confidence: 99%

Puerarin attenuates remifentanil‑induced postoperative hyperalgesia via targeting PAX6 to regulate the transcription of TRPV1

Yuan,

Liu,

Sun

et al. 2024

Mol Med Rep

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Remifentanil-induced hyperalgesia (RIH) is characterized by the emergence of stimulation-induced pain, including phenomena such as allodynia and thermal hyperalgesia following remifentanil infusion. As a sequence-specific DNA binding transcription factor, PAX6 positively and negatively regulates transcription and is expressed in multiple cell types in the developing and adult central nervous system. It was hypothesized that puerarin could relieve RIH via targeting PAX6 to regulate transcription of transient receptor potential cation channel subfamily V Member 1 (TRPV1). A total of 32 rats were randomly divided into five groups, namely control group, RI group, RI + 10 mg/kg puerarin group (RI + puerarin10), RI + 20 mg/kg puerarin group (RI + puerarin20), and RI + 40 mg/kg puerarin group (RI + puerarin40). Mechanical and thermal hyperalgesia were tested at −24, 2, 6, 24 and 48 h after remifentanil infusion. Following the sacrifice of rats after the last behavioral test, western blot was used to detect the expression levels of TRPV1 in the tissues; Immunofluorescence staining and western blotting were used to detect the expression of PAX6 in the spinal cord. PharmMapper and JASPAR were used to predict the binding sites of puerarin/PAX6/TRPV1. Chromatin immunoprecipitation-PCR and dual luciferase reporter assay were used to verify the targeting relationship between PAX6 and TRPV1. Immunofluorescence was used to detect the expression levels of TRPV1 and p-NR2B. The results revealed that puerarin (10, 20, 40 mg/kg) dose-dependently reduced thermal and mechanical hyperalgesia from 2 to 48 h after remifentanil infusion. Remifentanil infusion remarkably stimulated the expression of phosphorylated (p-)NR2B. Nevertheless, the increased amount of p-NR2B by RIH was dose-dependently suppressed by puerarin in rats. In conclusion, puerarin was revealed to attenuate postoperative RIH via targeting PAX6 to regulate the transcription of TRPV1.

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“…This compound possesses remarkable potential in various aspects of health and well-being. One of the fundamental attributes of puerarin is its capacity to scavenge free radicals and inhibit lipid peroxidation, thus affording protection to cells against oxidative damage [14]. This anti-oxidative action can be attributed to the phenolic hydroxyl group structure present in puerarin [15].…”

Section: Introductionmentioning

confidence: 99%

Puerarin Modulates Hepatic Farnesoid X Receptor and Gut Microbiota in High-Fat Diet-Induced Obese Mice

Yang,

Liu,

Chang

et al. 2024

IJMS

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Obesity is associated with alterations in lipid metabolism and gut microbiota dysbiosis. This study investigated the effects of puerarin, a bioactive isoflavone, on lipid metabolism disorders and gut microbiota in high-fat diet (HFD)-induced obese mice. Supplementation with puerarin reduced plasma alanine aminotransferase, liver triglyceride, liver free fatty acid (FFA), and improved gut microbiota dysbiosis in obese mice. Puerarin’s beneficial metabolic effects were attenuated when farnesoid X receptor (FXR) was antagonized, suggesting FXR-mediated mechanisms. In hepatocytes, puerarin ameliorated high FFA-induced sterol regulatory element-binding protein (SREBP) 1 signaling, inflammation, and mitochondrial dysfunction in an FXR-dependent manner. In obese mice, puerarin reduced liver damage, regulated hepatic lipogenesis, decreased inflammation, improved mitochondrial function, and modulated mitophagy and ubiquitin-proteasome pathways, but was less effective in FXR knockout mice. Puerarin upregulated hepatic expression of FXR, bile salt export pump (BSEP), and downregulated cytochrome P450 7A1 (CYP7A1) and sodium taurocholate transporter (NTCP), indicating modulation of bile acid synthesis and transport. Puerarin also restored gut microbial diversity, the Firmicutes/Bacteroidetes ratio, and the abundance of Clostridium celatum and Akkermansia muciniphila. This study demonstrates that puerarin effectively ameliorates metabolic disturbances and gut microbiota dysbiosis in obese mice, predominantly through FXR-dependent pathways. These findings underscore puerarin’s potential as a therapeutic agent for managing obesity and enhancing gut health, highlighting its dual role in improving metabolic functions and modulating microbial communities.

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Puerarin: A review of its mechanisms of action and clinical studies in ophthalmology

Cited by 22 publications

References 102 publications

Dual Self‐Assembly of Puerarin and Silk Fibroin into Supramolecular Nanofibrillar Hydrogel for Infected Wound Treatment

Dual Self‐Assembly of Puerarin and Silk Fibroin into Supramolecular Nanofibrillar Hydrogel for Infected Wound Treatment

Puerarin attenuates remifentanil‑induced postoperative hyperalgesia via targeting PAX6 to regulate the transcription of TRPV1

Puerarin Modulates Hepatic Farnesoid X Receptor and Gut Microbiota in High-Fat Diet-Induced Obese Mice

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