Publisher’s note

Abstract

We reported the rapid synthesis (<8s) of gold nanoparticles at room temperature using Acanthopanacis cortex extract (A-AuNPs). We characterized the A-AuNPs using several analytical techniques and found that nano-flower type A-AuNPs, which are known to possess a coarse surface with a high surface to volume ratio, conferring these particles with high binding capacity for various biological molecules. After confirming the stability of the nanoparticles, we investigated the anti-inflammatory effect of A-AuNPs in LPS-stimulated RAW264.7 cells. These nanoparticles inhibited LPS-induced iNOS and COX-2 protein as well as gene expression level, along with reduction of NO and PGE production. Furthermore, we observed that the A-AuNPs inhibited translocation of NF-κB and AP-1 through phosphorylation of MAPK signaling by western blot analysis. In summary, we synthesized gold nanoflowers in an economical and eco-friendly way using Acanthopanacis cortex extract and the resultant flower-like A-AuNPs had anti-inflammatory activity, highlighting their potential as therapeutic candidates for suppression of inflammatory-mediated diseases.

<p>Anti-neuroinflammatory effects of <em>Ephedra sinica Stapf</em> extract-capped gold nanoparticles in microglia</p>

“…The XRD pattern was determined with the following parameters: scanning range, 30–80; voltage, 40 kV; and current, 30 mA. FT-IR spectroscopy of ES extract and ES-GNs was performed using a FT-IR spectrophotometer (Spectrum GX, PerkinElmer, Inc., Boston, MA, USA) in the range between 4,000 and 400 cm.−1…”

“…Advances in nanotechnology allow the production of biocompatible nanoparticles with “green” synthesis techniques. Among the nanomaterials, gold nanoparticles can be synthesized with great precision using medicinal plants 1,2. Furthermore, medicinal plants are the most effective and high-performance reducing, capping, and stabilizing agents because their reducing, capping, and stabilizing capacity direct the synthesis of gold nanoparticles and enables well-programmed tuning of nanoscale materials 3–5.…”