Publisher Correction: The impact of smoking different tobacco types on the subgingival microbiome and periodontal health: a pilot study

Kawas, Sausan Al; Al-Marzooq, Farah; Rahman, Betul; Shearston, Jenni A.; Saad, Hiba; Benzina, Dalenda; Weitzman, Michael

doi:10.1038/s41598-021-89261-w

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“…Tobacco smoking disturbs the oral microbiome via immunosuppression, oxygen deficiency, antibiotic effects, and other likely mechanisms 3 . The subgingival and supra gingival microbiota composition in smokers of various tobacco products including medwakh, shisha, and cigarette was reported in our previous studies 4 , 5 . It has been reported that the microbiome of these types of tobacco smokers was altered in both supra and subgingiva, making them more susceptible to severe periodontal disorders 4 and dental caries 6 .…”

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confidence: 53%

Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth

Rani

Soares

Rahman

et al. 2023

Sci Rep

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The use of alternative tobacco products, particularly medwakh, has expanded among youth in the Middle East and around the world. The present study is conducted to investigate the biochemical and pathophysiological changes caused by medwakh smoking, and to examine the salivary metabolomics profile of medwakh smokers. Saliva samples were collected from 30 non-smokers and 30 medwakh smokers and subjected to metabolomic analysis by UHPLC-ESI-QTOF-MS. The CRP and Glutathione Peroxidase 1 activity levels in the study samples were quantified by ELISA and the total antioxidant capacity (TAC) by TAC assay kits. Statistical measurements and thorough validation of data obtained from untargeted metabolomics identified 37 uniquely and differentially abundant metabolites in saliva of medwakh smokers. The levels of phthalate, L-sorbose, cytosine, uridine, alpha-hydroxy hippurate, and L-nicotine were noticeably high in medwakh smokers. Likewise, 20 metabolic pathways were differentially altered in medwakh smokers. This study identified a distinctive saliva metabolomics profile in medwakh smokers associated with altered redox homeostasis, metabolic pathways, antioxidant system, and CRP levels. The impact of the altered metabolites in medwakh smokers and their diagnostic utility require further research in large cohorts.

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Section: Introductionmentioning

confidence: 53%

Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth

Rani

Soares

Rahman

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

Publisher Correction: The impact of smoking different tobacco types on the subgingival microbiome and periodontal health: a pilot study

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 1 publication

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Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth

Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth

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