Publisher Correction: Thalamic projections sustain prefrontal activity during working memory maintenance

Bolkan, Scott S.; Stujenske, Joseph M.; Parnaudeau, Sébastien; Spellman, Timothy; Rauffenbart, Caroline; Abbas, Atheir I.; Harris, Alexander Z.; Gordon, Joshua A.; Kellendonk, Christoph

doi:10.1038/s41593-018-0132-2

Cited by 7 publications

(4 citation statements)

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“…The MD thalamic nucleus was mostly represented by the CEN, sharing some clusters with the SAL. This seems to be a reasonable representation considering the major anatomical projections to the prefrontal cortex and orbitofrontal cortex and accounting for the functional associations with various cognitive functions, including working memory and executive function 13 , 14 , 16 , 20 , 65 . In addition, the DAN was only reflected in the pulvinar region.…”

Section: Discussionmentioning

confidence: 99%

Aberrant cortico-thalamo-cerebellar network interactions and their association with impaired cognitive functioning in patients with schizophrenia

Park

et al. 2023

Schizophr

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Evidence indicating abnormal functional connectivity (FC) among the cortex, thalamus, and cerebellum in schizophrenia patients has increased. However, the role of the thalamus and cerebellum when integrated into intrinsic networks and how those integrated networks interact in schizophrenia patients are largely unknown. We generated an integrative network map by merging thalamic and cerebellar network maps, which were parcellated using a winner-take-all approach, onto a cortical network map. Using cognitive networks, the default mode network (DMN), the dorsal attention network (DAN), the salience network (SAL), and the central executive network (CEN) as regions of interest, the FC of 48 schizophrenia patients was compared with that of 57 healthy controls (HCs). The association between abnormal FC and cognitive impairment was also investigated in patients. FC was lower between the SAL-CEN, SAL-DMN, and DMN-CEN and within-CEN in schizophrenia patients than in HCs. Hypoconnectivity between the DMN-CEN was correlated with impaired cognition in schizophrenia patients. Our findings broadly suggest the plausible role of the thalamus and cerebellum in integrative intrinsic networks in patients, which may contribute to the disrupted triple network and cognitive dysmetria in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Aberrant cortico-thalamo-cerebellar network interactions and their association with impaired cognitive functioning in patients with schizophrenia

Park

et al. 2023

Schizophr

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“…However, hippocampal CA3 receives glutamatergic projections mainly from the DG. Moreover, thalamic projections sustain activity of the prefrontal cortex during working memory maintenance [94], and the basolateral amygdala and mPFC forming strong reciprocal synaptic connections support acquisition and extinction of emotional memories [95]. To explore whether the neuroprotective effects of TGR5 are associated with neural circuits of CA3 and mPFC, we selectively blocked the glutamatergic and GABAergic projections using antagonists CPP, NBQX, and gabazine and showed that activation of TGR5 stimulated excitatory pyramidal neuron firing in the hippocampal CA3 and mPFC not due to postsynaptic response.…”

Section: Discussionmentioning

confidence: 99%

Activation of TGR5 Ameliorates Streptozotocin-Induced Cognitive Impairment by Modulating Apoptosis, Neurogenesis, and Neuronal Firing

Yuan

et al. 2022

Oxidative Medicine and Cellular Longevity

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Takeda G protein-coupled receptor 5 (TGR5) is the first known G protein-coupled receptor specific for bile acids and is recognized as a new and critical target for type 2 diabetes and metabolic syndrome. It is expressed in many brain regions associated with memory such as the hippocampus and frontal cortex. Here, we hypothesize that activation of TGR5 may ameliorate streptozotocin- (STZ-) induced cognitive impairment. The mouse model of cognitive impairment was established by a single intracerebroventricular (ICV) injection of STZ (3.0 mg/kg), and we found that TGR5 activation by its agonist INT-777 (1.5 or 3.0 μg/mouse, ICV injection) ameliorated spatial memory impairment in the Morris water maze and Y-maze tests. Importantly, INT-777 reversed STZ-induced downregulation of TGR5 and glucose usage deficits. Our results further showed that INT-777 suppressed neuronal apoptosis and improved neurogenesis which were involved in tau phosphorylation and CREB-BDNF signaling. Moreover, INT-777 increased action potential firing of excitatory pyramidal neurons in the hippocampal CA3 and medial prefrontal cortex of ICV-STZ groups. Taken together, these findings reveal that activation of TGR5 has a neuroprotective effect against STZ-induced cognitive impairment by modulating apoptosis, neurogenesis, and neuronal firing in the brain and TGR5 might be a novel and potential target for Alzheimer’s disease.

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“…As a higher order thalamic relay nucleus, the MD is involved in the regulation of the cortico-thalamo-cortical circuit, which means that it can integrate information from the hypothalamus, basal ganglia, olfactory system, amygdala, and cortex, and finally feed back to the cortex (26,27). It is highly correlated with learning, memory, attention, execution, cognition and emotion (13,17,24,28). Therefore, changes in MD neuronal activity may affect the function of normal cortico-thalamocortical circuits and may play an important role in the occurrence of depression.…”

Section: Discussionmentioning

confidence: 99%

“…Previous anatomical evidence has demonstrated interconnections between the MD and the orbitofrontal cortex (OFC), medial prefrontal cortex (mPFC), and granular insular cortex (23)(24)(25). While the mPFC is a brain region that is highly correlated with mood, to observe whether the MD-mPFC pathway is related to depression, we first observed the relationship between the mPFC and depression-like behavior.…”

Section: Increased Excitability Of Mpfc Glu Neurons In Depression-lik...mentioning

confidence: 99%

Thalamic and medial prefrontal cortical circuits mediate social defeat stress-induced depression-like behaviors

Li¹,

Wang²,

Meng³

et al. 2022

Preprint

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The mediodorsal thalamus (MD) is interconnected with the medial prefrontal cortex (mPFC) and works together to promote some forms of behavioral flexibility. But the relationship between the MD-mPFC circuit and depression is remain unknown. Here, we show that in male susceptible mice, MDGLU neuronal calcium signaling activity is reduced. Chemogenetic inhibition of MDGLU neuronal in male C57BL/J mice resulted in behavioral abnormalities, whereas in susceptible mice, activation of MDGLU neuronal ameliorated depression-like behavior. Brain slice electrophysiology and fiber optic recordings reveal elevated excitability of mPFCGLU neurons in male susceptible mice. Furthermore, we found that in susceptible mice, mPFCGLU neurons exhibited decreased inhibitory postsynaptic currents and unchanged excitatory postsynaptic currents, and increased E/I ratios, whereas activation of MDGLU neurons restored these electrophysiological properties abnormal. Optogenetic activation of the MD-mPFC circuit ameliorates depression-like behaviors in susceptible mice. Taken together, these data demonstrate that the MD-mPFC circuit controls distinct aspects of depression-like behavior.

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Publisher Correction: Thalamic projections sustain prefrontal activity during working memory maintenance

Cited by 7 publications

References 0 publications

Aberrant cortico-thalamo-cerebellar network interactions and their association with impaired cognitive functioning in patients with schizophrenia

Aberrant cortico-thalamo-cerebellar network interactions and their association with impaired cognitive functioning in patients with schizophrenia

Activation of TGR5 Ameliorates Streptozotocin-Induced Cognitive Impairment by Modulating Apoptosis, Neurogenesis, and Neuronal Firing

Thalamic and medial prefrontal cortical circuits mediate social defeat stress-induced depression-like behaviors

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