Publisher Correction: Musculoskeletal involvement in childhood leukemia: Characteristics and survival outcomes

Kittivisuit, Sirinthip; Sripornsawan, Pornpun; Songthawee, Natsaruth; Chavananon, Shevachut; McNeil, Edward; Chotsampancharoen, Thirachit

doi:10.1186/s12969-022-00695-6

Cited by 1 publication

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“…Arthritis that has been reported during the diagnosis of pediatric leukemia is likely associated with leukemia-induced bone lesions. 165 However, correlating altered bone remodeling in pediatric patients who received chemotherapy 166 to treatment outcomes and the rate of relapse may provide insight into the role of bone remodeling in pediatric blood cancer. In this section, we focus only on age-associated MDS and myeloid malignancies and review the coupling between bone remodeling and the tumor microenvironment.…”

Section: Skeletal Aging and The Bone Marrow Microenvironmentmentioning

confidence: 99%

The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

et al. 2023

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Prior research establishing that bone interacts in coordination with the bone marrow microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell populations. Recent advances in intravital imaging has suggested that the expansion of hematopoietic stem cells (HSCs) and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone remodeling. These findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses. A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel interventions. To advance this understanding, herein, we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic compartment. Specifically, we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting approaches. We then discuss unresolved questions and ambiguities that remain in the field.

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Section: Skeletal Aging and The Bone Marrow Microenvironmentmentioning

confidence: 99%