Publisher Correction: miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein

Tonouchi, Erina; Gen, Yasuyuki; Muramatsu, Tomoki; Hiramoto, Hidekazu; Tanimoto, Kousuke; Inoue, Jun; Inazawa, Johji

doi:10.1038/s41598-018-24861-7

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miR-29b targets the 3′-UTR of BRD4 to regulate the expression of BRD4 and has an inverse correlation (low miR-29b and high BRD4) in chronic obstructive pulmonary disease (COPD) patients (Tang et al, 2019). miR-1340 targets BRD3 and BRD4 to suppress tumor cell growth (Tonouchi et al, 2018). Diminished miR-29b level leads to enhanced BRD4 level and activation in cutaneous T-cell lymphoma (Kohnken et al, 2018).…”

Section: Mechanisms Regulating Expression Of Bromodomain and Extra-terminal Domain Proteinsmentioning

confidence: 99%

The Functions of BET Proteins in Gene Transcription of Biology and Diseases

Cheung

Kim

Zhou

2021

Front. Mol. Biosci.

View full text Add to dashboard Cite

The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional regulators in biology. They are characterized by two tandem bromodomains (BDs) that bind to lysine-acetylated histones and transcription factors, recruit transcription factors and coactivators to target gene sites, and activate RNA polymerase II machinery for transcriptional elongation. Pharmacological inhibition of BET proteins with BD inhibitors has been shown as a promising therapeutic strategy for the treatment of many human diseases including cancer and inflammatory disorders. The recent advances in bromodomain protein biology have further uncovered the complex and versatile functions of BET proteins in the regulation of gene expression in chromatin. In this review article, we highlight our current understanding of BET proteins’ functions in mediating protein–protein interactions required for chromatin-templated gene transcription and splicing, chromatin remodeling, DNA replication, and DNA damage repair. We further discuss context-dependent activator vs. repressor functions of individual BET proteins, isoforms, and bromodomains that may be harnessed for future development of BET bromodomain inhibitors as emerging epigenetic therapies for cancer and inflammatory disorders.

show abstract

Section: Mechanisms Regulating Expression Of Bromodomain and Extra-terminal Domain Proteinsmentioning

confidence: 99%

The Functions of BET Proteins in Gene Transcription of Biology and Diseases

Cheung

Kim

Zhou

2021

Front. Mol. Biosci.

View full text Add to dashboard Cite

show abstract

Vimentin-positive and Alpha-fetoprotein-elevated Nuclear Protein of the Testis Midline Carcinoma: A Case Report and Review of the Literature

et al. 2021

View full text Add to dashboard Cite

Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare malignant tumor expressing NUT with BRD4/3 rearrangements and is sometimes misdiagnosed as germinoma, especially in alpha-fetoprotein (AFP)-elevated cases. A 28-year-old man had a mediastinal tumor with multiple bone metastases and elevated AFP levels. Imaging/laboratory findings led to a pathological diagnosis of extragonadal germinoma. After unsuccessful treatment with etoposide-cisplatin, he was re-diagnosed with sarcoma due to vimentin-positive findings. He was treated with adriamycin-ifosfamide, which resulted in disease-control. A posthumous examination clarified the NUT rearrangement. Even in cases with characteristic findings, such as elevated AFP levels and vimentin positivity, NMC should be considered as a differential diagnosis. We note, however, that adriamycin-ifosfamide has some efficacy in such cases.

show abstract

LINC00978 promotes bladder cancer cell proliferation, migration and invasion by sponging miR‑4288

Wang¹,

Wang³

et al. 2019

Mol Med Report

View full text Add to dashboard Cite

long noncoding rnas regulate the occurrence and progression of numerous types of cancer, including bladder cancer (Bca). However, the role of long intergenic non-protein coding rna 978 (linc00978) in Bca remains unknown. In the present study, it was identified that the LINC00978 expression level was significantly increased in BCa tissues compared with adjacent normal tissues. By performing cell proliferation, colony formation, Transwell and Matrigel assays, it was demonstrated that LINC00978 knockdown significantly inhibited the proliferation, migration and invasion of Bca cells. conversely, overexpression of linc00978 resulted in opposite effects. Mechanistically, it was demonstrated that linc00978 served as a competing endogenous rna to sponge microrna-4288 (mir-4288), and linc00978 knockdown significantly increased the expression level of miR-4288 in BCa cells. Furthermore, it was demonstrated that the expression of linc00978 was inversely correlated with the mir-4288 expression level in Bca tissues. Furthermore, by performing a rescue assay, it was identified that inhibition of miR-4288 was able to reverse the effects of linc00978 knockdown on proliferation, migration and invasion of Bca cells. collectively, the present study demonstrated that linc00978 promoted Bca progression by sponging mir-4288, suggesting that linc00978 may represent a potential therapeutic target for Bca treatment.

show abstract

Publisher Correction: miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

Cited by 3 publications

References 0 publications

The Functions of BET Proteins in Gene Transcription of Biology and Diseases

The Functions of BET Proteins in Gene Transcription of Biology and Diseases

Vimentin-positive and Alpha-fetoprotein-elevated Nuclear Protein of the Testis Midline Carcinoma: A Case Report and Review of the Literature

LINC00978 promotes bladder cancer cell proliferation, migration and invasion by sponging miR‑4288

Contact Info

Product

Resources

About