Publisher Correction: Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Geng, Hao; Xue, Changhui; Mendonca, Janet; Sun, Xiao Xin; Liu, Qiong; Reardon, Patrick N.; Chen, Yingxiao; Qian, Kendrick; Hua, Vivian; Chen, Alice; Pan, Freddy; Yuan, Julia; Dang, Sang; Beer, Tomasz M.; Dai, Mu Shui; Kachhap, Sushant K.; Qian, David Z.

doi:10.1038/s41467-018-07872-w

Cited by 2 publications

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“…Besides APO10, TKTL1 is another biomarker underlying epitope detection in monocytes (EDIM) blood tests. By comparing the sensitivity of the EDIM blood test with conventional tumor biomarkers, studies have shown that this novel test might aid the detection and diagnosis of cholangiocellular carcinoma, PC, and CRC 33 .…”

Section: Discussionmentioning

confidence: 99%

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Identification of a hypoxia-related gene prognostic signature in colorectal cancer based on bulk and single-cell RNA-seq

Jiang

Li³

et al. 2023

Sci Rep

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Colorectal cancer (CRC) is the most common and fatal tumor in the gastrointestinal system. Its incidence and mortality rate have increased in recent years. Hypoxia, a persistent physiological tumor feature, plays a vital role in CRC tumorigenesis, metastasis, and tumor microenvironment (TME). Therefore, we constructed a hypoxia-related gene (HRG) nomogram to predict overall survival (OS) and explored the role of HRGs in the CRC TME. The Cancer Genome Atlas (TCGA) dataset was used as the training set, and two Gene Expression Omnibus datasets (GSE39582 and GSE103479) were used as the testing sets. HRGs were identified using the Gene Set Enrichment Analysis (GSEA) database. An HRG prognostic model was constructed in the training set using the least absolute shrinkage and selection operator regression algorithm and validated in the testing sets. Then, we analyzed tumor-infiltrating cells (TICs) using the cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) algorithm. Furthermore, single-cell next-generation RNA sequencing (RNA-seq) was used to investigate HRG expression in different TICs in the GSE139555 dataset. Finally, reverse transcription polymerase chain reactions (RT-PCR) were used to validate HRG mRNA expression in ten pairs of CRC normal and cancer tissue samples. A six HRG prognostic signature was constructed, with a superior OS prediction ability in CRC patients (area under the receiver operating characteristic curve (AUC) at one year: 0.693, AUC at three years: 0.712, and AUC at five years: 0.780). GSEA enrichment analysis identified six pathways enriched in the high-risk group. The TIC analysis indicated that the high-risk group had lower T-cell expression and higher neutrophil expression than the low-risk group. Furthermore, immune-related genes had an inseparable relationship with the HRG prognostic signature. Based on single-cell RNA-seq data, we found elevated hexokinase 1 (HK1) and glucose-6-phosphate isomerase (GPI) gene expression in natural killer (NK) and CD8+ T cells. RT-PCR in ten CRC normal-tumor tissue pairs showed that expression of the signature’s six HRGs varied differently in cancerous and paracancerous tissues. The constructed HRG signature successfully predicted the OS of whole-stage CRC patients. In addition, we showed that the signature’s six HRGs were closely associated with the TME in CRC, where hypoxia inhibits the antitumor function of T cells.

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Section: Discussionmentioning

confidence: 99%

“…However, GPI transcription is suppressed by AR during hypoxia. When GPI was inhibited, therapeutic resistance under hypoxia was reduced, and enzalutamide efficacy was increased 35 . Upregulated glycolysis could improve organ tolerance to hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Identification of a hypoxia-related gene prognostic signature in colorectal cancer based on bulk and single-cell RNA-seq

Jiang

Li³

et al. 2023

Sci Rep

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Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network

Chen

Wei

Yang

et al. 2020

Food and Chemical Toxicology

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Publisher Correction: Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Abstract: The original version of this Article contained errors in Fig. 7. In panels e and f, the graph titles incorrectly read 'LNCaP-AdtNs' and 'LAPC4-AdtNs', respectively. These errors have now been corrected in both the PDF and HTML versions of the Article.

Cited by 2 publications

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Identification of a hypoxia-related gene prognostic signature in colorectal cancer based on bulk and single-cell RNA-seq

Identification of a hypoxia-related gene prognostic signature in colorectal cancer based on bulk and single-cell RNA-seq

Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network

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