Publisher Correction: A brainstem map for visceral sensations

Chen, Ran; Boettcher, Jack C.; Kaye, Judith A; Gallori, Catherine; Liberles, Stephen D.

doi:10.1038/s41586-022-05414-5

Cited by 3 publications

(2 citation statements)

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“…Given the central role of the vagus in interoception ( Chen et al, 2021 ), MEMRI may provide a valuable tool for investigating the functional neural circuits that allow the brain to interact with visceral organs for both physical and mental health. The NTS, which receives vagal projections, maps visceral sensations by organs ( Ran et al, 2022 ). Physiological or pathophysiological states concerning the brain’s interaction with multiple organs may manifest a signature in the vagal relay onto the NTS, which may be captured by MEMRI with local injection to the nodose ganglion.…”

Section: Discussionmentioning

confidence: 99%

“…The internal structure of the vagus nerve is complex, encompassing nerve fibers with diverse morphological features, fascicular organizations, and functional associations ( Stakenborg et al, 2020 ; Havton et al, 2021 ). Approximately 80% of vagal nerve fibers are afferent ( Berthoud and Neuhuber, 2000 ; Powley et al, 2019 ), enabling sensory neurons in the nodose ganglia (NG) to relay a variety of bodily signals to the nucleus tractus solitarius (NTS) in the brainstem ( Prescott and Liberles, 2022 ; Ran et al, 2022 ). These signals, once in the NTS, can further ascend to various brain regions ( Craig, 2002 ; Browning and Travagli, 2014 ; Berntson and Khalsa, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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In vivo tracing of the ascending vagal projections to the brain with manganese enhanced magnetic resonance imaging

Oleson,

Cao,

Wang

et al. 2023

Front. Neurosci.

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IntroductionThe vagus nerve, the primary neural pathway mediating brain-body interactions, plays an essential role in transmitting bodily signals to the brain. Despite its significance, our understanding of the detailed organization and functionality of vagal afferent projections remains incomplete.MethodsIn this study, we utilized manganese-enhanced magnetic resonance imaging (MEMRI) as a non-invasive and in vivo method for tracing vagal nerve projections to the brainstem and assessing their functional dependence on cervical vagus nerve stimulation (VNS). Manganese chloride solution was injected into the nodose ganglion of rats, and T1-weighted MRI scans were performed at both 12 and 24 h after the injection.ResultsOur findings reveal that vagal afferent neurons can uptake and transport manganese ions, serving as a surrogate for calcium ions, to the nucleus tractus solitarius (NTS) in the brainstem. In the absence of VNS, we observed significant contrast enhancements of around 19–24% in the NTS ipsilateral to the injection side. Application of VNS for 4 h further promoted nerve activity, leading to greater contrast enhancements of 40–43% in the NTS.DiscussionThese results demonstrate the potential of MEMRI for high-resolution, activity-dependent tracing of vagal afferents, providing a valuable tool for the structural and functional assessment of the vagus nerve and its influence on brain activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivo tracing of the ascending vagal projections to the brain with manganese enhanced magnetic resonance imaging

Oleson,

Cao,

Wang

et al. 2023

Front. Neurosci.

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The Neural Basis of Interoception

Terasawa,

Brewer

2024

Interoception

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In vivo Tracing of the Ascending Vagal Projections to the Brain with Manganese Enhanced Magnetic Resonance Imaging

Oleson

Cao

Wang

et al. 2023

Preprint

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The vagus nerve is the primary neural pathway that mediates the interactions between the brain and visceral organs. However, it is incompletely understood how the vagus nerve ascends bodily signals to the brain. Here, we explored manganese-enhanced magnetic resonance imaging (MEMRI) for in vivo tracing of vagal nerve projections to the brainstem and assessing their functional dependence on cervical vagus nerve stimulation. Manganese chloride solution was injected into either the left or right nodose ganglion. T1-weighted MRI at 12 or 24 hours following the injection showed that vagal afferent neurons inside the nodose ganglion could uptake and transport manganese ions, as a surrogate of calcium ions, to the nucleus tractus solitarius in the brainstem ipsilateral to the injection side, showing about 19 to 24% contrast enhancement. Four hours of vagus nerve stimulation further promoted nerve activity and resulted in greater contrast enhancement of 40 to 43%. These results demonstrate the feasibility of using MEMRI for structural and functional assessment of vagal afferents and their influences on brain activity.

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Publisher Correction: A brainstem map for visceral sensations

Cited by 3 publications

References 0 publications

In vivo tracing of the ascending vagal projections to the brain with manganese enhanced magnetic resonance imaging

In vivo tracing of the ascending vagal projections to the brain with manganese enhanced magnetic resonance imaging

The Neural Basis of Interoception

In vivo Tracing of the Ascending Vagal Projections to the Brain with Manganese Enhanced Magnetic Resonance Imaging

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