Public Perceptions on the Influence of Diet and Kidney Stone Formation

Marsh, Benjamin M.; Sathianathen, Niranjan; Tejpaul, Resha; Albersheim-Carter, Jacob; Bearrick, Elizabeth; Borofsky, Michael S.

doi:10.1089/end.2019.0010

Cited by 8 publications

(11 citation statements)

References 14 publications

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“…Interestingly, even individuals with a personal history of kidney stones could not correctly identify most stone favorable food and beverage items. This differs from a study published by Alghamdi et al and Marsh et al where individuals with a history of kidney stones demonstrated better knowledge of dietary habits that favor kidney stone formation [ 11 , 20 ].…”

Section: Discussioncontrasting

confidence: 79%

“…Coffee, tea, and alcohol are considered unhealthy and have thus been marked as stone favorable by most respondents when they in reality have a protective effect on kidney stone formation. Interestingly, in contrast to the findings in Marsh et al study, despite being considered healthy, spinach was correctly identified as stone favorable by most [ 11 ]. Strangely so, fewer kidney stone formers correctly identified spinach and beetle nut as stone favorable as compared to the general population.…”

Section: Discussioncontrasting

confidence: 77%

“…To the best of our knowledge, only one study has previously aimed to gauge the perception of the population regarding the influence of commonly used dietary items. The afore-mentioned study was conducted in the United States and so understandably will differ significantly owing to the difference in dietary habits in this part of the world [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Perception of Dietary Influences on Renal Stone Formation Among the General Population

Bashir¹,

Zuberi²,

Musharraf³

et al. 2022

Cureus

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Introduction Urolithiasis is a common disorder worldwide with an increasing prevalence and high recurrence rate. This makes preventive measures like dietary modification an essential part of patient care. This study focuses on gauging the perception of dietary habits favoring kidney stone formation. Materials and methods A cross-sectional questionnaire-based study was conducted at Aga Khan University, Karachi, Pakistan. For nine food items and 14 beverages, respondents chose one of four options with regards to their relationship with stone formation, i.e. “increasing”, “decreasing”, “no effect”, and “do not know”. Responses were matched against evidence from the literature to generate correct and incorrect responses, thereby gauging perception for individual items. Results Seven hundred and three participants including 69 (9.6%) with a prior history of kidney stones, were recruited for the study. Participants with a personal history of kidney stone disease were older (odds ratio {OR}: 1.042 CI 1.020-1.064) with a significantly higher family history of stones (OR: 2.151 CI: 1.472-3.144). The majority were managed medically (87%) but never received dietary counseling (57%). Water, soft drinks, and tomatoes were the only three items out of 23 that were correctly identified by >50% of the participants with regards to their effect on stone formation. Responses did not differ significantly between those with stone disease and those without. Conclusion There is a lack of awareness among the general population, including individuals with a prior history of kidney stones regarding dietary prevention of kidney stone disease. This demonstrates a lack of existing dietary counseling thus necessitating the need for incorporating it at a mass level.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Perception of Dietary Influences on Renal Stone Formation Among the General Population

Bashir¹,

Zuberi²,

Musharraf³

et al. 2022

Cureus

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“…However, the mechanism responsible for renal tubular epithelial cell injury during the development of stones has not been fully illuminated. High oxalate intake has been a key dietary factor actuating renal stone [18]. In the present study, we found that sodium oxalate treatment inhibited the proliferation and migration of MDCK cells by inducing cell cycle arrest.…”

Section: Discussionsupporting

confidence: 55%

Inactivation of the Wnt/β-catenin signaling contributes to the epithelial barrier dysfunction induced by sodium oxalate in canine renal epithelial cells

Fang

Yang

et al. 2021

Preprint

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Background Nephrolithiasis (also known as renal stones) is a common disease condition in companion animals, including dogs and cats. Dysfunction of renal tubular epithelial cells involves in the pathogenesis of renal stones. However, a functional role of Wnt/β-catenin signaling and its contribution to nephrolithiasis remains unknown. Results In the present study, we found that Mardin-Darby canine kidney (MDCK) cells treated with sodium oxalate resulted in reduced cell proliferation and migration, which was associated with the G0/G1 phase arrest of cell cycle progression. In addition, sodium oxalate exposure led to decreased transepithelial electrical resistance (TEER) and increased paracellular permeability. The deleterious effect of sodium oxalate on epithelial barrier function was related to decreased protein abundances of claudin-1, occludin, zonula occludens (ZO)-1, ZO-2 and ZO-3. Of note, protein levels of p-β-catenin (Ser552) in MDCK cells were repressed by sodium oxalate, indicating an inhibitory effect on the Wnt/β-catenin signaling. Intriguingly, SB216763, a GSK-3β inhibitor, enhanced the expression p-β-catenin (Ser552), and protected against epithelial barrier dysfunction in sodium oxalate-treated MDCK cells. Conclusion Taken together, our results revealed a critical role of Wnt/β-catenin signaling on the epithelial barrier function of MDCK cells. Activation of Wnt/β-catenin signaling might be an potentially therapeutic target for the treatment of renal stones in animals.

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“…Moreover, there is evidence that diet and food choice can seriously influence stone formation; however, the study revealed confusion in the choice of certain diets among the public. 8 According to recent studies, the prevalence of obesity and associated non-communicable diseases like diabetes are 32.3% and 15.5%, respectively, among expatriates in the UAE (which is the predominant population); these diseases may continue to rise with lack of interventions, 9 and subsequently increase the prevalence of kidney stones.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the understanding about kidney stones among adults in the United Arab Emirates

Aldaher

Kadhim

Al-Roub

et al. 2021

Journal of Taibah University Medical Sciences

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Objectives The prevalence of kidney stones is increasing worldwide. Multiple risk factors are believed to contribute to the development of kidney stones such as lifestyle, diet, and global warming. In the United Arab Emirates (UAE), there has been limited research exploring the prevalence and risk factors of kidney stones. This study attempts to assess the understanding and prevalence of kidney stones among adults in the UAE. Methods In this cross-sectional study, data were collected using a self-administered questionnaire, distributed among 515 participants (20–49 years old) from Abu Dhabi, Dubai, Ajman, and Sharjah states. IBM SPSS version 25 was used for data analysis. Results The mean of knowledge score was 56.4% (n = 500). There was no correlation between the knowledge of those who had experienced kidney stones and those who did not. Furthermore, a family history of kidney stones increased the risk of developing stones by 2.27 times. Among participants reporting signs, symptoms, diagnosis, and the management of kidney stones, the knowledge and understanding about kidney stones was high. However, the perceptions of the same cohort about dietary precautions were limited. While analysing the sources of knowledge, the Internet and mass media were twice as important as physicians in educating the population. Conclusion This study shows that the study cohort from the UAE population was aware of certain aspects of kidney stones but was quite naïve about its consequential risk factors. This highlights the importance of promoting education about kidney stones through health campaigns.

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Public Perceptions on the Influence of Diet and Kidney Stone Formation

Cited by 8 publications

References 14 publications

Perception of Dietary Influences on Renal Stone Formation Among the General Population

Perception of Dietary Influences on Renal Stone Formation Among the General Population

Inactivation of the Wnt/β-catenin signaling contributes to the epithelial barrier dysfunction induced by sodium oxalate in canine renal epithelial cells

Evaluating the understanding about kidney stones among adults in the United Arab Emirates

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