Public health risks associated with methadone in Iran: A systematic review and meta-analysis

Rostam–Abadi, Yasna; Gholami, Jaleh; Noroozi, Alireza; Ansari, Mina; Baheshmat, Shahab; Hamzehzadeh, Marziyeh; Ghadirzadeh, Mohammad Reza; Vahdani, Bita; Ekhtiari, Hamed; Mojtabai, Ramin; Rahimi‐Movaghar, Afarin

doi:10.1016/j.drugpo.2021.103529

Cited by 8 publications

(10 citation statements)

References 71 publications

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“…Adverse reactions following immunization may be any undesirable sign or symptom of disease and laboratory findings [38] , [39] including local and systemic adverse reactions. Vaccines that present perfect efficacy against specific pathogens and induce limited or no adverse reactions are the ideal vaccines.…”

Section: Discussionmentioning

confidence: 99%

Adverse events following COVID-19 vaccination: A systematic review and meta-analysis

Kouhpayeh

Ansari

2022

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Adverse events following COVID-19 vaccination: A systematic review and meta-analysis

Kouhpayeh

Ansari

2022

International Immunopharmacology

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“…Our previous study showed that methadone poisoning increased from 2000 to 2010 [ 45 ]. The systemic review of methadone-related poisoning in Iran found that it caused 10.4% of adult cases and 16.0% of child cases [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Age- and gender-specific acute poisoning with drugs and medications affecting nervous system

Mesgarpour,

Faridfar,

Rezaei

et al. 2024

BMC Pharmacol Toxicol

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Background We investigated acute poisonings resulting from medications affecting the nervous system and illicit substances at Loghman Hakim Hospital in Tehran. Methods We retrospectively reviewed patient records at Iran’s largest tertiary toxicology referral center between January 2010 and December 2015. We analyzed the prevalence, trend, age and gender distribution of acute poisoning caused by nervous system agents. Results The present study included 16,657 (57.27%) males and 12,426 (42.73%) females, resulting in 29,083 patients. The median age of men and women was 29 and 26 years, respectively (p < 0.0001). There were 12,071 (72.47%) men and 10,326 (83.10%) women under the age of 40 (p < 0.001). Most cases were intentional (69.38% in men and 79.00% in women, p < 0.001) and 44.10% had a history of poisoning. The proportions of men and women varied significantly between different age groups and nervous system agents. For women, the most common agent was alprazolam, whereas for men, methadone. The overall trend of acute poisoning with drug used in addictive disorders, opioids and alcohol was increasing but decreasing with benzodiazepines and antidepressants. Acute poisoning by nervous system agents led to more deaths in men (1.95% vs. 0.56%; p < 0.001). Conclusions Methadone intoxication was common especially among young men and most of these intoxications were intentional. Women and men aged 20–29 most frequently suffer poisoning from alprazolam and clonazepam, respectively. Women over 60 and men over 30 used opium. Illicit drugs caused more than half of the deaths, and opium dominated. This study may create awareness and develop educational and preventive gender and age-specific local programs.

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“…Efforts were made to adapt to the situation by offering digital services, telehealth services (Zhen-6 Duan et al, 2022), larger quantities of take-home maintenance medications, and home delivery services («Funders Support Mental Health Care: COVID-19 And Before.», 2020; James C. Ramos, n.d.). However, unsupervised medication-based treatments may have posed a risk of overdose and fatality on SUD individuals (Rostam-Abadi et al, 2022;Volkow, 2020). Moreover, flu-like symptoms from SARS-CoV2 overlap with opioid withdrawal symptoms, hence, may have increased the likelihood of overdosing (Dunlop et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Substance use and substance use disorders in relation to COVID-19: qualitative experiences of people who use drugs in Jordan

Wazaify,

AlZyoud,

Shahin

et al. 2024

Journal of Substance Use

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BackgroundMonitoring substance use and Substance Use Disorders (SUD) during global pandemics is essential, as individuals who engage in such activities may be at greater risk for infections as well as economic and social complications. This study aimed to describe the impact of COVID-19 on substance use and SUD, any changes that occurred in patterns of use, and services provided, the main challenges faced and if and how they had been overcome. MethodsA qualitative study consisting of face-to-face semi-structured interviews with a sample of SUD patients from 3 main addiction treatment centres in Jordan. Recruitment stopped once data saturation was reached. Interviews were transcribed and analysed using NVivo-R1 software, and thematic analysis was undertaken. ResultsA total of 17 individuals were interviewed (male, aged 19-52 years). Five key themes emerged from a narrative analysis: Impact of COVID-19 on the availability of substances, 3 the pattern of use, social life and its relation to SUD, impact on tobacco smoking, and finally on the user's health, awareness and hygienic measures. ConclusionsThis study provided in-depth information to inform, support, and customize the design of interventions to mitigate the negative effects of substance use and SUD-related outcomes in a rapidly changing pandemic.

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Public health risks associated with methadone in Iran: A systematic review and meta-analysis

Cited by 8 publications

References 71 publications

Adverse events following COVID-19 vaccination: A systematic review and meta-analysis

Adverse events following COVID-19 vaccination: A systematic review and meta-analysis

Age- and gender-specific acute poisoning with drugs and medications affecting nervous system

Substance use and substance use disorders in relation to COVID-19: qualitative experiences of people who use drugs in Jordan

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