Public Health Implication of Bacteriuria and Antibiotic Susceptibility of Bacteria Isolates in Schistosoma haematobium-Infected School Pupils in Southeast Nigeria

Uneke, Chigozie Jesse; Ugwuoru, Cdc; Ngwu, B A F; Ogbu, Ogbonnaya; Agala, C.U.

doi:10.12927/whp.2006.18277

whp

2006

DOI: 10.12927/whp.2006.18277

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Public Health Implication of Bacteriuria and Antibiotic Susceptibility of Bacteria Isolates in Schistosoma haematobium-Infected School Pupils in Southeast Nigeria

Chigozie Jesse Uneke

Cdc Ugwuoru²,

B A F Ngwu³

et al.

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Cited by 7 publications

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“…According to Rutter and Beer (1975) and Mansfield and Urban (1996), a Trichuris suis infection can also modify the natural saprophytic intestinal flora of pigs by these mechanisms. The indirect interaction between bacteria and parasites is also well known in human pathology, as in the case, for example, of Schistosoma species and Enterobacteria associated infection, which can result in bacteraemia, bacteriuria and prolonged septicaemia (Lo Verde and others 1980, Melhem and Lo Verde 1984, Gendrel 1993, Uneke and others 2006).…”

mentioning

confidence: 99%

Bacteria isolated from 25 hydatid cysts in sheep, cattle and goats

Ziino¹,

Giuffrida²,

Bilei

et al. 2009

Veterinary Record

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mentioning

confidence: 99%

Bacteria isolated from 25 hydatid cysts in sheep, cattle and goats

Ziino¹,

Giuffrida²,

Bilei

et al. 2009

Veterinary Record

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Schistosomiasis haematobium prevalence among haematuric patients: Parasitological and immuno-assay

Ghieth

Lotfy

2017

Beni-Suef University Journal of Basic and Applied Sciences

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A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology

et al. 2012

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Schistosoma haematobium is the etiologic agent for urogenital schistosomiasis, a major source of morbidity and mortality for more than 112 million people worldwide. Infection with S. haematobium results in a variety of immunopathologic sequelae caused by parasite oviposition within the urinary tract, which drives inflammation, hematuria, fibrosis, bladder dysfunction, and increased susceptibility to urothelial carcinoma. While humans readily develop urogenital schistosomiasis, the lack of an experimentally-tractable model has greatly impaired our understanding of the mechanisms that underlie this important disease. We have developed an improved mouse model of S. haematobium urinary tract infection that recapitulates several aspects of human urogenital schistosomiasis. Following microinjection of purified S. haematobium eggs into the bladder wall, mice consistently develop macrophage-rich granulomata that persist for at least 3 months and pass eggs in their urine. Importantly, egg-injected mice also develop urinary tract fibrosis, bladder dysfunction, and various urothelial changes morphologically reminiscent of human urogenital schistosomiasis. As expected, S. haematobium egg-induced immune responses in the immediate microenvironment, draining lymph nodes, and systemic circulation are associated with a Type 2-dominant inflammatory response, characterized by high levels of interleukin-4, eosinophils, and IgE. Taken together, our novel mouse model may help facilitate a better understanding of the unique pathophysiological mechanisms of epithelial dysfunction, tissue fibrosis, and oncogenesis associated with urogenital schistosomiasis.

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Public Health Implication of Bacteriuria and Antibiotic Susceptibility of Bacteria Isolates in Schistosoma haematobium-Infected School Pupils in Southeast Nigeria

Cited by 7 publications

References 0 publications

Bacteria isolated from 25 hydatid cysts in sheep, cattle and goats

Bacteria isolated from 25 hydatid cysts in sheep, cattle and goats

Schistosomiasis haematobium prevalence among haematuric patients: Parasitological and immuno-assay

A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology

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