Public Health Impacts of Foodborne Mycotoxins

Wu, Felicia; Groopman, John D.; Pestka, James J.

doi:10.1146/annurev-food-030713-092431

Cited by 465 publications

(330 citation statements)

References 121 publications

(109 reference statements)

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“…Aflatoxin contamination of many important seed crops causes enormous agricultural economic losses [35]. Several antimicrobial agents including Cu fungicides have been examined for A. flavus growth inhibition as potential post-harvest interventions [36].…”

Section: Resultsmentioning

confidence: 99%

Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus

et al. 2018

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The ubiquitous fungus Aspergillus flavus is notorious for contaminating many important crops and food-stuffs with the carcinogenic mycotoxin, aflatoxin. This fungus is also the second most frequent Aspergillus pathogen after A. fumigatus infecting immunosuppressed patients. In many human fungal pathogens including A. fumigatus, the ability to defend from toxic levels of copper (Cu) is essential in pathogenesis. In A. fumigatus, the Cu-fist DNA binding protein, AceA, and the Cu ATPase transporter, CrpA, play critical roles in Cu defense. Here, we show that A. flavus tolerates higher concentrations of Cu than A. fumigatus and other Aspergillus spp. associated with the presence of two homologs of A. fumigatus CrpA termed CrpA and CrpB. Both crpA and crpB are transcriptionally induced by increasing Cu concentrations via AceA activity. Deletion of crpA or crpB alone did not alter high Cu tolerance, suggesting they are redundant. Deletion of both genes resulted in extreme Cu sensitivity that was greater than that following deletion of the regulatory transcription factor aceA. The ΔcrpAΔcrpB and ΔaceA strains were also sensitive to ROI stress. Compared to wild type, these mutants were impaired in the ability to colonize maize seed treated with Cu fungicide but showed no difference in virulence on non-treated seed. A mouse model of invasive aspergillosis showed ΔcrpAΔcrpB and to a lesser degree ΔaceA to be significantly reduced in virulence, following the greater sensitivity of ΔcrpAΔcrpB to Cu than ΔaceA.

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Section: Resultsmentioning

confidence: 99%

Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus

et al. 2018

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“…Aflatoxin will be released by the body through bile, milk, egg, and urine. When aflatoxin can not be excreted from the body, there will be pathological changes and cause some symptoms such as birth defects (teratogenic effects), cancer (human and animals) and the death (Wu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Aflatoxin B1 Contamination Correlation with Aspergillus flavus in Animal Feed Raw Materials Imported through the Port of Tanjung Perak Surabaya, Indonesia

Arios¹,

Indrawati²,

Pamungkas³

2017

Int. J. Curr. Res. Biosci. Plant Biol.

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A b s t r a c t A r t i c l e I n f oThis study aimed to measure the incidence rate of aflatoxin B1 contamination in feed raw materials (MBM and PPM) imported through Port of Tanjung Perak Surabaya, and its relation to the growth of the fungi that produce it. ELISA (Enzyme Linked Immunosorbent Assay) competitive was conducted to identify Aflatoxin B1 and followed by HPLC (High Performance Liquid Chromatography). Fungal identification was conducted as a macroscopic and microscopic observation. ELISA test showed 55 of 84 (55.95%) samples were positive for aflatoxin B1 contamination, while 3 of 7 (42.85%) samples tested by HPLC were positive. The result of fungal identification showed 1 of 12 samples positive Aspergillus flavus, and others types of fungi. AFB1 contamination in animal feed raw materials is likely to have occurred in the country of origin, whereas the growth of the fungus is due to the level of humidity and temperature during the transportation and storage process.

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“…These diseases are attributed to risk factors such as high daily intake of aflatoxins and high incidence of hepatitis B [24]. Morevoer, mycotoxins are often related to the impairment of children' growth [14,25,26]. Very recently, it has been shown that insulin-like growth factor 1 (IGF-1) axis may represent a common causal pathway in mycotoxin effects on hepatocellular carcinoma as well as growth retardation [27].…”

Section: Adverse Effects Of Mycotoxins On Humansmentioning

confidence: 99%

Mycotoxins and Nuclear Receptors: A Still Underexplored Issue

Dall’Asta¹

2016

Nuclear Receptor Research

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Abstract.Mycotoxins are fungal secondary metabolites that can be found in food commodities worldwide. They exert a wide range of adverse effects towards humans and animals. Although toxicological studies have addressed these food contaminants over decades, their mode of actions as well as their synergistic effects are still to be deeply clarified. Among the toxicological targets, nuclear receptors have been identified by several studies. Besides the estrogenic effect, a wider range of endocrine and neuroendocrine disrupting effects have been reported so far. This review is aimed at addressing the recent advances in toxicology, and at highlighting possible gaps of knowledge.

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Public Health Impacts of Foodborne Mycotoxins

Cited by 465 publications

References 121 publications

Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus

Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus

Aflatoxin B1 Contamination Correlation with Aspergillus flavus in Animal Feed Raw Materials Imported through the Port of Tanjung Perak Surabaya, Indonesia

Mycotoxins and Nuclear Receptors: A Still Underexplored Issue

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