Puberty moderates genetic influences on disordered eating

Klump, Kelly L.; Perkins, Patrick; Burt, S. Alexandra; McGue, Matt; Iacono, William G.

doi:10.1017/s0033291707000189

Cited by 92 publications

(117 citation statements)

References 37 publications

(52 reference statements)

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“…Puberty has been a primary focus of this research, as puberty occurs between pre-to mid-adolescence, puberty is related to a cascade of biological and psychosocial transitions, and puberty is associated with increases in the incidence of disordered eating in females (Bulik 2002;Graber et al 1994). Developmental twin studies have confirmed that puberty increases or "moderates" the heritability of disordered eating symptoms, even after controlling for age (Culbert et al 2009;Klump et al 2003;Klump et al 2007b). Little-to-no genetic influences on disordered eating were found in prepubertal 11-year-old twins, whereas genetic effects accounted for approximately 50% of the variance in 11-year-old twins who were in mid-to late puberty (Klump et al 2003).…”

Section: Puberty and The Heritability Of Disordered Eating Symptomsmentioning

confidence: 99%

The Influence of Gender and Puberty on the Heritability of Disordered Eating Symptoms

Culbert

Racine

Klump

2010

Behavioral Neurobiology of Eating Disorders

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Eating disorders and disordered eating symptoms are clearly heritable, but recent research has suggested that genetic and environmental influences on disordered eating symptoms vary as a function of gender and development. Data are limited, but evidence suggests that gender may moderate the type of genetic risk, rather than the magnitude of genetic effects, on disordered eating symptoms. Only a moderate proportion of the genetic influences on disordered eating symptoms are shared between males and females. In females, at least some of the unique genetic risk may be related to puberty and ovarian hormone regulation. The heritability of disordered eating symptoms in females increases with both pubertal development and increasing levels of estradiol. Although much more research is needed to elucidate specific mechanisms, gonadal hormones may be promising candidates for understanding sex and developmental effects and the ways in which genes exert their influence on disordered eating.

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Section: Puberty and The Heritability Of Disordered Eating Symptomsmentioning

confidence: 99%

The Influence of Gender and Puberty on the Heritability of Disordered Eating Symptoms

Culbert

Racine

Klump

2010

Behavioral Neurobiology of Eating Disorders

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Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

“…Few studies that have assessed whether subjects with early vs later onset of a disorder vary in terms of the influence of genetics on the risk of becoming eating disordered. [28][29][30] More research is needed to better understand these associations.Although teasing or negative comments about weight have been proposed as risk factors for becoming eating disordered, the evidence is mixed. Haines et al 10 found that the females in Project EAT (Eating Among Teens) who were teased were more likely to become frequent dieters 5 years later, but they did not observe an association between teasing and the development of bulimic behavior.…”

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confidence: 99%

Family, Peer, and Media Predictors of Becoming Eating Disordered

Field¹,

Javaras²,

Aneja³

et al. 2008

Arch Pediatr Adolesc Med

143

132

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Objective-To identify predictors of becoming eating disordered among adolescents. Design-Prospective cohort study. Setting-Self-report questionnaires.Subjects-Girls (n=6916) and boys (n=5618), aged 9 to 15 years at baseline, in the ongoing Growing Up Today Study (GUTS).Main Exposures-Parent, peer, and media influences.Main Outcome Measures-Onset of starting to binge eat or purge (ie, vomiting or using laxatives) at least weekly.Results-During 7 years of follow-up, 4.3% of female subjects and 2.3% of male subjects (hereafter referred to as "females" and "males") started to binge eat and 5.3% of females and 0.8% of males started to purge to control their weight. Few participants started to both binge eat and purge. Rates and risk factors varied by sex and age group (<14 vs ≥14 years). Females younger than 14 years whose mothers had a history of an eating disorder were nearly 3 times more likely than their peers to start purging at least weekly (odds ratio, 2.8; 95% confidence interval, 1.3-5.9); however, maternal history of an eating disorder was unrelated to risk of starting to binge eat or purge in older adolescent females. Frequent dieting and trying to look like persons in the media were independent predictors of binge eating in females of all ages. In males, negative comments about weight by fathers was predictive of starting to binge at least weekly. Additional Contributions: S. Bryn Austin, ScD, and Ruth Streigel-Moore, PhD, provided comments on preliminary analyses.Author Contributions: Dr Field had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Field, Camargo, and Laird. Acquisition of data: Field and Camargo. Analysis and interpretation of data: Field, Javaras, Aneja, Kitos, and Taylor. Drafting of the manuscript: Field, Kitos, and Taylor. Critical revision of the manuscript for important intellectual content: Field, Javaras, Aneja, Kitos, Camargo, Taylor, and Laird. Conclusions-Risk factors for the development of binge eating and purging differ by sex and by age group in females. Maternal history of an eating disorder is a risk factor only in younger adolescent females.Concerns about weight and body shape are common in preadolescents and adolescents 1,2 and are probably related to the development of unhealthy weight control behaviors and binge eating. However, because of the lack of large prospective studies of non-treatmentseeking samples, little is known with certainty about the development of disordered eating (eg, engaging in bulimic behaviors) or eating disorders.Although there have not been many large prospective studies of disordered eating (ie, engaging in binge eating or purging) or full-criteria eating disorders 3 among non-treatmentseeking samples, a variety of risk factors for disordered eating and eating disorders have been proposed. The support for some of these purported risk factors is stronger than for others. 4 The risk factors with the strongest support, which a...

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“…Genetic and environmental contributions to the variance in DE at age 11 years (which are represented as a 11 , c 11, and e 11 in the figure) are obtained by simply squaring their respective path estimates. The genetic and environmental variance in DE at age 14 years is decomposed into components attributable to the genetic and environmental effects on DE at age 11 years (represented as the square of a 21, c 21, e 21 ) as well as residual components that are independent of the genetic and environmental variance at age 11 years (represented as the square of a 22 , c 22, e 22, ).…”

Section: Statistical Analysesmentioning

confidence: 99%

Changes in Genetic and Environmental Influences on Disordered Eating Across Adolescence

Klump¹,

Burt²,

McGue³

et al. 2007

Arch Gen Psychiatry

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Puberty moderates genetic influences on disordered eating

Abstract: These findings suggest that puberty influences the expression of genes for disordered eating.

Cited by 92 publications

References 37 publications

The Influence of Gender and Puberty on the Heritability of Disordered Eating Symptoms

The Influence of Gender and Puberty on the Heritability of Disordered Eating Symptoms

Family, Peer, and Media Predictors of Becoming Eating Disordered

Changes in Genetic and Environmental Influences on Disordered Eating Across Adolescence

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