Puberty as a DOHaD programming window: high-fat diet induces long-term hepatic dysfunction in male rats
Beatriz Gonçalves dos Santos,
Rosiane Aparecida Miranda,
Lucas Paulo Jacinto Saavedra
et al.
Abstract:The aim of this study was to evaluate whether high-fat (HF) diet intake during puberty can program obesity as well as generate glucose imbalance and hepatic metabolic dysfunctions in adult life. Male Wistar rats were randomly assigned into two groups: rats fed standard chow (NF) and rats fed a HF from postnatal 30-day-old (PND30) until PND60. Then, both groups were fed a standard chow from PND60 until PND120. Euthanasia and samples collections occurred at PND120. HF animals were overweight (+11%) and had incre… Show more
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