Puberté précoce et syndrome des ovaires polykystiques: à propos de 13 observations

Acceleration of Luteinizing Hormone Pulse Frequency in Adolescent Girls with a History of Central Precocious Puberty with versus without Hyperandrogenism

“…The adolescents in the present study come from a population of girls with a history of ICPP who have a high prevalence of signs suggestive of hyperandrogenism (menstrual disturbances, hirsutism, acne). This observation supports the possibility raised by the authors mentioned above [1,2,3,4,5] that ICPP girls could be at risk of further developing PCOS. However, little information exists about the underlying mechanism driving this association.…”

“…Other studies also report the occurrence of PCOS following ICPP [1, 2, 4, 13, 14]. Treatment of ICPP does not itself cause PCOS because such patients have been treated with medroxyprogesterone, cyproterone acetate, GnRH agonists or nothing [1,2,3,4]. Three out of 5 CPPA and all CPPB girls in our series had received GnRH agonists.…”

“…The first observation comes from Petrus et al [12], who described a girl with precocious puberty treated with medroxyprogesterone acetate at the age of 4 years, who later presented with laparoscopic ‘Stein-Leventhal syndrome’ and typical clinical and hormonal alterations. Several years later, the same group reported 13 adolescents with a history of ICPP, hyperandrogenemia, elevated LH concentrations and polycystic ovaries [3]. Recently, Trimèche et al [5], based on their own experience as well as data in the literature, described different clinical expressions of PCOS in the pubertal period, one of which is a ‘post-precocious puberty form’.…”

“…However, some girls develop features of hyperandrogenism similar to those at polycystic ovary syndrome (PCOS) during adolescence [1,2,3,4,5]. Few hormonal studies are available in such patients.…”

Le consensus de Rotterdam appliqué à l'adolescente : quels examens prescrire et comment les interpréter pour établir le diagnostic de SOPK ?

“…Devant des troubles des cycles, dont nous vérifions s'ils sont sensibles à la prise de progestérone, nous n'envisageons de bilan que s'ils sont durables, au-delà des deux premières années de règles, ou s'ils se sont installés secondairement après plusieurs mois de cycles normaux. Un bilan sera également plus aisément réalisé s'il y a des antécédents particuliers comme un contexte familial, une séquence petit poids de naissanceprémature pubarche, ou dans quelques cas un antécédent d'authentique puberté précoce [6].…”