Pubertal testis volume, age at pubertal onset, and adolescent blood pressure: Evidence from Hong Kong's “Children of 1997” birth cohort

Kwok, Man Ki; Leung, Gabriel M.; Schooling, CM

doi:10.1002/ajhb.22993

Cited by 9 publications

(10 citation statements)

References 38 publications

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“…85 The aforementioned data could support the negative relationship between pulse pressure and mean TV found in this study. In contrast, previous studies showed a positive association between mean 31 or systolic 86 BP and mean TV.…”

Section: F I G U R Econtrasting

confidence: 80%

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The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

et al. 2020

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Background Infertility affects 7%‐12% of men, and its etiology is unknown in half of cases. To fill this gap, use of the male genital tract color‐Doppler ultrasound (MGT‐CDUS) has progressively expanded. However, MGT‐CDUS still suffers from lack of standardization. Hence, the European Academy of Andrology (EAA) has promoted a multicenter study (“EAA ultrasound study”) to assess MGT‐CDUS characteristics of healthy, fertile men to obtain normative parameters. Objectives To report (a) the development and methodology of the “EAA ultrasound study,” (b) the clinical characteristics of the cohort of healthy, fertile men, and (c) the correlations of both fertility history and seminal features with clinical parameters. Methods A cohort of 248 healthy, fertile men (35.3 ± 5.9 years) was studied. All subjects were asked to undergo, within the same day, clinical, biochemical, and seminal evaluation and MGT‐CDUS before and after ejaculation. Results The clinical, seminal, and biochemical characteristics of the cohort have been reported here. The seminal characteristics were consistent with those reported by the WHO (2010) for the 50th and 5th centiles for fertile men. Normozoospermia was observed in 79.6% of men, while normal sperm vitality was present in almost the entire sample. Time to pregnancy (TTP) was 3.0[1.0‐6.0] months. TTP was negatively correlated with sperm vitality (Adj.r =−.310, P = .011), but not with other seminal, clinical, or biochemical parameters. Sperm vitality and normal morphology were positively associated with fT3 and fT4 levels, respectively (Adj.r = .244, P < .05 and Adj.r = .232, P = .002). Sperm concentration and total count were negatively associated with FSH levels and positively, along with progressive motility, with mean testis volume (TV). Mean TV was 20.4 ± 4.0 mL, and the lower reference values for right and left testes were 15.0 and 14.0 mL. Mean TV was negatively associated with gonadotropin levels and pulse pressure. Varicocoele was found in 33% of men. Conclusions The cohort studied confirms the WHO data for all semen parameters and represents a reference with which to assess MGT‐CDUS normative parameters.

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Section: F I G U R Econtrasting

confidence: 80%

“…However, the aforementioned studies were performed in infertile men 31 and adolescents, 86 European population was 20.0 ± 5.0 mL. 87,90 In addition, normal TV at Prader evaluation has been previously suggested as > 14-15 mL, although this threshold was derived from a few studies.…”

Section: F I G U R Ementioning

confidence: 99%

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

et al. 2020

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“…It is possible that there are relevant changes in hormonal status during puberty. Indeed, puberty onset at younger ages seems to be associated with increases BP in boys and girls [3,4]. A previous longitudinal study found that a decrease in BP was associated to higher intakes of fruit and vegetable intake only in pre-pubertal stages [9].…”

Section: Discussionmentioning

confidence: 95%

“…Adolescence is considered a vulnerable period of high BP development, because the highest peak of BP occurs during puberty [3,4] and most of the lifestyle habits are established during this period [5]. Therefore, it is important to find the modifiable determinants of elevated BP in order to implement lifestyle programs in youth to prevent the development of hypertension.…”

Section: Introductionmentioning

confidence: 99%

Fruit, vegetable consumption and blood pressure in healthy adolescents: A longitudinal analysis from the LabMed study

Rosário

Santos

Lopes

et al. 2018

Nutrition, Metabolism and Cardiovascular Diseases

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“…These drawings corresponded to Tanner stages 1–5 ( 34 ). We derived age at thelarche or pubarche as daughter’s age at the midpoint between adjacent questionnaires on which participants had previously reported stage 1 and subsequently reported stage 2 ( 35 ).…”

Section: Methodsmentioning

confidence: 99%

Associations Between Maternal Prepregnancy Body Mass Index and Gestational Weight Gain and Daughter’s Age at Menarche

Lawn

Lawlor

Fraser

2017

American Journal of Epidemiology

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Earlier puberty and menarche are associated with adverse health outcomes. Reported associations of maternal adiposity with daughter’s age at menarche are inconsistent. We examined associations between maternal prepregnancy body mass index (BMI; weight (kg)/height (m)2) and gestational weight gain (GWG) and daughter’s ages at menarche (n = 3,935 mother-offspring pairs), pubarche (Tanner stage 2 for pubic hair) (n = 2,942 pairs), and thelarche (Tanner stage 2 for breast development) (n = 2,942 pairs) in the Avon Longitudinal Study of Parents and Children, a prospective United Kingdom pregnancy cohort study (baseline 1991–1992). During a follow-up period of up to 17 years (1991–2008), mean menarcheal age was 12.6 (standard deviation, 1.2) years. Both maternal prepregnancy BMI and GWG were inversely associated with daughter’s age at menarche after adjustment for maternal age, parity, socioeconomic status, smoking, maternal menarcheal age, and ethnicity (mean differences were −0.34 months (95% confidence interval: −0.45, −0.22) per BMI unit and −0.17 months (95% confidence interval: −0.26, −0.07) per kg, respectively). Associations remained unchanged after adjustment for birth weight and gestational age but were attenuated to the null when results were adjusted for daughter’s prepubertal BMI. Similar results were found for ages at pubarche and thelarche. These findings indicate that greater prepregnancy BMI and GWG are associated with earlier puberty in daughters and that these associations are mediated by daughters’ prepubertal BMIs.

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Pubertal testis volume, age at pubertal onset, and adolescent blood pressure: Evidence from Hong Kong's “Children of 1997” birth cohort

Cited by 9 publications

References 38 publications

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

Fruit, vegetable consumption and blood pressure in healthy adolescents: A longitudinal analysis from the LabMed study

Associations Between Maternal Prepregnancy Body Mass Index and Gestational Weight Gain and Daughter’s Age at Menarche

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