Pubertal probiotics mitigate lipopolysaccharide-induced programming of the hypothalamic-pituitary-adrenal axis in male mice only

Smith, Kevin B.; Murray, E. Selkirk; Gregory, James Gardner; Liang, Jacky; Ismail, Nafissa

doi:10.1016/j.brainresbull.2021.09.017

Cited by 16 publications

(9 citation statements)

References 45 publications

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“…Probiotics are the most efficient vectors used to re-establish disruption of the gut–brain axis (GBA), mitigating lipopolysaccharide (LPS) programming in a sex-dependent manner the hypothalamic–pituitary–adrenal (HPA) axis [ 32 ]. Early exposure causes a decrease in Lactobacillus genera, with L. reuteri replenishment countering bacterial endotoxins action [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

Doroftei

Ilie

Diaconu³

et al. 2022

Diagnostics

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Background: Antenatal depression (AND) and post-partum depression (PPD) are long-term debilitating psychiatric disorders that significantly influence the composition of the gut flora of mothers and infants that starts from the intrauterine life. Not only does bacterial ratio shift impact the immune system, but it also increases the risk of potentially life-threatening disorders. Material and Methods: Therefore, we conducted a narrative mini-review aiming to gather all evidence published between 2018–2022 regarding microflora changes in all three stages of pregnancy. Results: We initially identified 47 potentially eligible studies, from which only 7 strictly report translocations; 3 were conducted on rodent models and 4 on human patients. The remaining studies were divided based on their topic, precisely focused on how probiotics, breastfeeding, diet, antidepressants, exogenous stressors, and plant-derived compounds modulate in a bidirectional way upon behavior and microbiota. Almost imperatively, dysbacteriosis cause cognitive impairments, reflected by abnormal temperament and personality traits that last up until 2 years old. Thankfully, a distinct technique that involves fecal matter transfer between individuals has been perfected over the years and was successfully translated into clinical practice. It proved to be a reliable approach in diminishing functional non- and gastrointestinal deficiencies, but a clear link between depressive women’s gastrointestinal/vaginal microbiota and clinical outcomes following reproductive procedures is yet to be established. Another gut-dysbiosis-driving factor is antibiotics, known for their potential to trigger inflammation. Fortunately, the studies conducted on mice that lack microbiota offer, without a shadow of a doubt, insight. Conclusions: It can be concluded that the microbiota is a powerful organ, and its optimum functionality is crucial, likely being the missing puzzle piece in the etiopathogenesis of psychiatric disorders.

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Section: Resultsmentioning

confidence: 99%

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

Doroftei

Ilie

Diaconu³

et al. 2022

Diagnostics

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“…Treatment from weeks 5–7 with a probiotic containing multiple Lactobacillus strains prevented these changes, and normalized toll-like receptor-4 activity in the hypothalamic PVN in response to a novel stressor( Murray et al, 2019 ). As demonstrated by Smith et al, long-term effects of adolescent gut microbiota disturbances on depression- and anxiety-like behaviors appear to be primarily driven by maladaptive changes to the HPA axis, with pubertal LPS exposure decreasing PVN glucocorticoid receptor (GR) expression into adulthood, and pubertal probiotic (composed of multiple Lactobacillus strains) treatment blocking this LPS-induced programing( Smith et al, 2021 ). These results highlight the importance of adolescence as a developmental period during which long-term HPA-axis function, and neural and behavioral sequalae of prolonged HPA-axis hyperactivity, remain both vulnerable to microbiota disturbances and amenable to interventions targeting the microbiota.…”

Section: Probiotics As An Mgb-targeted Treatment For Adolescent Depre...mentioning

confidence: 99%

The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment

Freimer

Yang²,

Ho³

et al. 2022

Brain, Behavior, & Immunity - Health

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“…In addition to relying on these mediators, bacteria can directly participate in the intervention process. For example, LPS and peptidoglycan can activate the HPA axis by activating the innate immune system, which ultimately induces depression ( Gonzalez-Santana and Diaz Heijtz, 2020 ; Smith et al, 2021 ). There is also evidence that GM can directly modulate steroidogenesis in the gut and adrenal to exaggerate HPA axis response ( Vagnerová et al, 2019 ).…”

Section: Potential Mechanism Of Gut Microbiota Involved In the Regula...mentioning

confidence: 99%

Reviewing the role of gut microbiota in the pathogenesis of depression and exploring new therapeutic options

Han

Wang²,

Han³

et al. 2022

Front. Neurosci.

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The relationship between gut microbiota (GM) and mental health is one of the focuses of psychobiology research. In recent years, the microbial-gut-brain axis (MGBA) concept has gradually formed about this bidirectional communication between gut and brain. But how the GM is involved in regulating brain function and how they affect emotional disorders these mechanisms are tenuous and limited to animal research, and often controversial. Therefore, in this review, we attempt to summarize and categorize the latest advances in current research on the mechanisms of GM and depression to provide valid information for future diagnoses and therapy of mental disorders. Finally, we introduced some antidepressant regimens that can help restore gut dysbiosis, including classic antidepressants, Chinese materia medica (CMM), diet, and exogenous strains. These studies provide further insight into GM’s role and potential pathways in emotion-related diseases, which holds essential possible clinical outcomes for people with depression or related psychiatric disorders. Future research should focus on clarifying the causal role of GM in disease and developing microbial targets, applying these findings to the prevention and treatment of depression.

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Pubertal probiotics mitigate lipopolysaccharide-induced programming of the hypothalamic-pituitary-adrenal axis in male mice only

Cited by 16 publications

References 45 publications

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment

Reviewing the role of gut microbiota in the pathogenesis of depression and exploring new therapeutic options

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