PUB136 Effect of PD-L1 Tumor Expression on Clinical Benefit of Personalized Dendritic Cell Based Vaccine in Patients with Non-Small Cell Lung Cancer

Abstract

Background: The purpose of this study was to experimentally assess the dosimetric impact of leaf interdigitation for NSCLC sliding window IMRT (dMLC) plans in Monaco TPS. Methods: 20 NSCLC patients (one to four isolate targets) previously treated were re-planned for dMLC with and without leaf interdigitation. Elekta synergy linear accelerator was used in this study. The treatment plans were evaluated on the following dosimetric variables: conformity index, homogeneity index and the normal lung sparing. Results: For one isolate target, the plan quality was equivalent with and without leaf interdigitation (p>0.05). For multiple targets, leaf interdigitation could improve the conformity index obviously (p<0.05). Meanwhile, leaf interdigitation showed well sparing for the normal lung (p<0.05). Conclusion: The study shows that leaf interdigitation can improve the plan quality for multiple isolate targets NSCLC dMLC plans in Monaco TPS.