PTPRR (protein tyrosine phosphatase, receptor type, R)

Erkens, Mirthe; Kremer, H.P.H.; Pulido, Rafael; Hendriks, Wiljan

doi:10.4267/2042/52073

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…The downregulation of BEST3 mRNA and protein is associated with a significant reduction in the Cl − current, suggesting BEST3 is essential for this process [59]. The protein encoded by PT-PRR is a member of the protein tyrosine phosphatase (PTP) family, which are signalling molecules involved in regulating various cellular processes, including cell growth, differentiation, mitosis and oncogenic transformation [60]. PTPRR inhibits MAPK signalling by sequestering MAPKs in the cytoplasm in an inactive form [60,61].…”

Section: Discussionmentioning

confidence: 99%

“…The protein encoded by PT-PRR is a member of the protein tyrosine phosphatase (PTP) family, which are signalling molecules involved in regulating various cellular processes, including cell growth, differentiation, mitosis and oncogenic transformation [60]. PTPRR inhibits MAPK signalling by sequestering MAPKs in the cytoplasm in an inactive form [60,61]. In some cancers, such as breast and colon cancer, overexpression of a protein that silences PTPRR leads to activation of MAPK signalling and epithelial-mesenchymal transition (EMT) [61].…”

Section: Discussionmentioning

confidence: 99%

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Use of Optical Genome Mapping to Detect Structural Variants in Neuroblastoma

Barford,

Whittle,

Weir

et al. 2023

Cancers

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Background: Neuroblastoma is the most common extracranial solid tumour in children, accounting for 15% of paediatric cancer deaths. Multiple genetic abnormalities have been identified as prognostically significant in neuroblastoma patients. Optical genome mapping (OGM) is a novel cytogenetic technique used to detect structural variants, which has not previously been tested in neuroblastoma. We used OGM to identify copy number and structural variants (SVs) in neuroblastoma which may have been missed by standard cytogenetic techniques. Methods: Five neuroblastoma cell lines (SH-SY5Y, NBLW, GI-ME-N, NB1691 and SK-N-BE2(C)) and two neuroblastoma tumours were analysed using OGM with the Bionano Saphyr® instrument. The results were analysed using Bionano Access software and compared to previous genetic analyses including G-band karyotyping, FISH (fluorescent in situ hybridisation), single-nucleotide polymorphism (SNP) array and RNA fusion panels for cell lines, and SNP arrays and whole genome sequencing (WGS) for tumours. Results: OGM detected copy number abnormalities found using previous methods and provided estimates for absolute copy numbers of amplified genes. OGM identified novel SVs, including fusion genes in two cell lines of potential clinical significance. Conclusions: OGM can reliably detect clinically significant structural and copy number variations in a single test. OGM may prove to be more time- and cost-effective than current standard cytogenetic techniques for neuroblastoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Use of Optical Genome Mapping to Detect Structural Variants in Neuroblastoma

Barford,

Whittle,

Weir

et al. 2023

Cancers

View full text Add to dashboard Cite

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The potential roles of vesicle-enclosed miRNAs in communication between macrophages and cancer cells in tumor microenvironment

Korabečná¹,

Koutova²,

Tesařová³

2017

neo

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Functional microRNA (miRNA) molecules are transported in extracellular vesicles among tumor cells and cells of the immune system. Macrophages as integral components of tumor microenvironment are known as potential contributors to tumor growth and progression. We searched for studies which could provide a direct link between the particular miRNAs transported between cancer cells and macrophages and experimental evidence of subsequent alterations in biological functions of target cells. The validated targets of such microRNAs were found using miRWalk database. These targets were further subjected to analysis by DAVID (Database for Annotation, Visualization and Integrated Discovery) to find the most prominent cellular events that could be potentially regulated in macrophages by miRNAs originated from cancer cells and vice versa. We found that the 5 miRNAs (let-7b, miR-21, miR-29a, miR-222-3p, miR-451) derived from cancer cells may together regulate 2304 target genes in macrophages. The genes involved in regulation of apoptosis, regulation of gene expression and protein transport were significantly overrepresented in this set. Four of the five sets of target genes for these individual miRNAs overlap in MYC oncogene. MYC dependent transcriptional program is responsible for cell cycle entry and regulates the inflammatory response in macrophages.Both miRNAs for which the functional transports from macrophages to cancer cells were experimental proven (miR-223, miR-142-3p) target total 684 genes including some well-known tumor suppressors like TP53 or APC. Suppression of tumor suppressor genes by miRNAs derived from macrophages may eventually contribute to cancer cell proliferation.Due to the complexity of tumor microenvironment, the altered expression profiles of its components affected by miRNA uptake from extracellular vesicles could contribute to the outcome of carcinogenesis therefore the vesicular transport of miRNAs should be studied more extensively in this context.

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PTPRR (protein tyrosine phosphatase, receptor type, R)

Abstract: Abstract:Review on PTPRR, with data on DNA/RNA, on the protein encoded and where the gene is implicated.

Cited by 2 publications

References 56 publications

Use of Optical Genome Mapping to Detect Structural Variants in Neuroblastoma

Use of Optical Genome Mapping to Detect Structural Variants in Neuroblastoma

The potential roles of vesicle-enclosed miRNAs in communication between macrophages and cancer cells in tumor microenvironment

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