Abstract:Background
Hemorrhage shock (HS) is characterized by decreased tissue oxygenation and organ damage due to severe blood loss. Acute lung injury (ALI) is a common complication of HS. Protein tyrosine phosphatase receptor type O (PTPRO) is abnormally up-regulated in the rat lungs after trauma/HS.
Methods
To elucidate the regulatory mechanism of PTPRO in lung inflammation following HS, we established a rat model of HS via withdrawing blood by a catheter inserted into the femoral artery followed by resuscitation.… Show more
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