PtIV- or MoVI-substituted decavanadates inhibit the growth of Mycobacterium smegmatis

Kostenkova, Kateryna; Arhouma, Zeyad; Postal, Kahoana; Rajan, Ananthu; Kortz, Ulrich; Nunes, Giovana G.; Crick, Dean C.; Crans, Debbie C.

doi:10.1016/j.jinorgbio.2021.111356

Cited by 16 publications

(18 citation statements)

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“…A second wash (2 x) increased lipid order and three washes (3 x) increased lipid order to values seen in untreated cells. Lee et al, 2008;Kostenkova et al, 2021). The peaks observed in 51 V NMR confirm the synthesis of the compound and are identical to those reported in the literature (Supplementary Figures S1-S2) (Uk Lee et al, 2008;Kostenkova et al, 2021).…”

Section: Open Access Edited Bysupporting

confidence: 84%

“…The peaks observed in 51 V NMR confirm the synthesis of the compound and are identical to those reported in the literature (Supplementary Figures S1-S2) (Uk Lee et al, 2008;Kostenkova et al, 2021). Monomolybdononavanadate ([MoV 9 O 28 ] 5-) abbreviated V 9 Mo) solution was freshly prepared following the reported procedure for the sodium salt (Na 5 [MoV 9 O 28 ]•10H 2 O) (Sánchez-Lombardo et al, 2016;Kostenkova et al, 2021). The peaks observed in 51 V NMR confirm the synthesis of the compound and were identical to those reported in the literature (Supplementary Figures S3-S4) (Sánchez-Lombardo et al, 2016;Kostenkova et al, 2021).…”

Section: Open Access Edited Bysupporting

confidence: 83%

“…Lee et al, 2008;Kostenkova et al, 2021). The peaks observed in 51 V NMR confirm the synthesis of the compound and are identical to those reported in the literature (Supplementary Figures S1-S2) (Uk Lee et al, 2008;Kostenkova et al, 2021). Monomolybdononavanadate ([MoV 9 O 28 ] 5-) abbreviated V 9 Mo) solution was freshly prepared following the reported procedure for the sodium salt (Na 5 [MoV 9 O 28 ]•10H 2 O) (Sánchez-Lombardo et al, 2016;Kostenkova et al, 2021).…”

Section: Open Access Edited Bysupporting

confidence: 71%

“…Decametalates have anticancer and antidiabetic effects in eukaryotic cell lines and tissues and inhibit the growth of prokaryotic Mycobacterium tuberculosis mc2 6,230 (M. tb) and Mycobacterium smegmatis mc2 155 (M. smeg is now reclassified as a Mycolicibacterium) (Aureliano et al, 2021;Aureliano et al, 2022). Interestingly, in bacterial cell lines, inhibitory growth effects of V 10 were greater than the effects of the known potent phosphatase inhibitor monovanadate (V 1 ) (Figure 1) (Samart et al, 2018;Kostenkova et al, 2021). The wide range of biological effects of decametalates in prokaryotic and eukaryotic cells motivates further work with these compounds given their potential pharmacologic value.…”

Section: Open Access Edited Bymentioning

confidence: 99%

“…Monomolybdononavanadate ([MoV 9 O 28 ] 5-) abbreviated V 9 Mo) solution was freshly prepared following the reported procedure for the sodium salt (Na 5 [MoV 9 O 28 ]•10H 2 O) (Sánchez-Lombardo et al, 2016;Kostenkova et al, 2021). The peaks observed in 51 V NMR confirm the synthesis of the compound and were identical to those reported in the literature (Supplementary Figures S3-S4) (Sánchez-Lombardo et al, 2016;Kostenkova et al, 2021). The pH in NMR speciation experiments was adjusted by using either 0.1 M HCl or 0.1 M NaOH prepared in doubly deionized water (DDI) water.…”

Section: Open Access Edited Bymentioning

confidence: 99%

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Polyoxidovanadates [MoVIVV9O28]5- and [H2PtIVVV9O28]5- interact with CHO cell plasma membrane lipids causing aggregation and activation of a G protein-coupled receptor

et al. 2023

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Mono substituted heteropolyoxidovanadates, when compared to effects of a corresponding isopolyoxidovanadate (POV), were found to be more effective initiators of signal transduction by a G protein-coupled receptor (GPCR), specifically the luteinizing hormone receptor (LHR). Here we report that LHRs signal productively when CHO cells expressing the receptor are treated with two heteropolyoxidovanadates PtIV in monoplatino(IV)nonavanadate(V) ([H2PtVIVV9O28]5-, V9Pt), and MoIV in monomolybdo(VI)nonavanadate(V) (Mo[VIVV9O28]5-, V9Mo). Both substituted decavanadate derivatives were more effective than decavanadate which is more charged, has greater stability and forms the [V10O28]6- anion (V10) in cell culture medium at pH 7.4. For viable CHO cells expressing 10 k or 32 k LHR/cell and treated with 11 μM V9Pt and 13 μM V9Mo, mono substituted heteropolyoxidovanadates significantly decreased the packing of plasma membrane lipids for about 1 h. This brief change in membrane structure was accompanied by increased aggregation of LHR and cell signaling as indicated by increased intracellular levels of cAMP. More pronounced changes in lipid packing and LHR signaling were associated with short acting heteropolyoxidovanadates than with the more stable V10. When LHR was overexpressed, V9Pt and V9Mo had little or no effect on membrane lipid packing or receptor aggregation and the LHR was constitutively activated as indicated by elevated intracellular cAMP levels. Speciation of V9Pt and V9Mo in H2O and cell medium was monitored using 51V NMR spectroscopy and confirmed that V9Pt and V9Mo had greater effects on CHO cells despite decomposing more rapidly in the cell growth medium. Thus, under conditions that promote CHO cell growth, V9Pt and V9Mo, despite their smaller molecular charge and their reduced stability, favor LHR signaling over that induced by V10. Importantly, under the same experimental conditions, CHO cells treated with V9Pt and V9Mo do not exhibit as strong toxic effects observed for cells treated with the longer lived V10. In summary, unlike the longer lived V10 which is more growth inhibitory to cells, monosubstituted heteropolyoxidovanadates are more effective in transiently initiating signaling by a G protein-coupled receptor but, because of rapid hydrolysis, inhibit cell growth less.

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Section: Open Access Edited Bysupporting

confidence: 84%

Section: Open Access Edited Bysupporting

confidence: 83%

Section: Open Access Edited Bysupporting

confidence: 71%

Section: Open Access Edited Bymentioning

confidence: 99%

Section: Open Access Edited Bymentioning

confidence: 99%

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Polyoxidovanadates [MoVIVV9O28]5- and [H2PtIVVV9O28]5- interact with CHO cell plasma membrane lipids causing aggregation and activation of a G protein-coupled receptor

et al. 2023

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All‐Inorganic Polyoxometalates Act as Superchaotropic Membrane Carriers

Barba‐Bon,

Gumerova,

Tanuhadi

et al. 2023

Advanced Materials

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Polyoxometalates (POMs) are known antitumoral, antibacterial, antiviral, and anticancer agents and considered as next‐generation metallodrugs. Herein, we report a new biological functionality in neutral physiological media, where selected mixed‐metal POMs are sufficiently stable and able to affect membrane transport of impermeable, hydrophilic, and cationic peptides (heptaarginine, heptalysine, protamine, and polyarginine). The uptake is observed in both, model membranes as well as cells, and attributed to the superchaotropic properties of the polyoxoanions. In view of the structural diversity of POMs these findings pave the way towards their biomedical application in drug delivery or for cell‐biological uptake studies with biological effector molecules or staining agents.This article is protected by copyright. All rights reserved

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Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PL^pro

Gil-Moles

Türck

Basu

et al. 2021

Chemistry A European J

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The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are commonly underrepresented in compound libraries that are used for screening in drug discovery campaigns, however, there is growing evidence for their role in medicinal chemistry. Based on previous results, we have selected more than 100 structurally diverse metal complexes for profiling as inhibitors of two relevant SARS‐CoV‐2 replication mechanisms, namely the interaction of the spike (S) protein with the ACE2 receptor and the papain‐like protease PL pro . In addition to many well‐established types of mononuclear experimental metallodrugs, the pool of compounds tested was extended to approved metal‐based therapeutics such as silver sulfadiazine and thiomersal, as well as polyoxometalates (POMs). Among the mononuclear metal complexes, only a small number of active inhibitors of the S/ACE2 interaction was identified, with titanocene dichloride as the only strong inhibitor. However, among the gold and silver containing complexes many turned out to be very potent inhibitors of PL pro activity. Highly promising activity against both targets was noted for many POMs. Selected complexes were evaluated in antiviral SARS‐CoV‐2 assays confirming activity for gold complexes with N‐heterocyclic carbene (NHC) or dithiocarbamato ligands, a silver NHC complex, titanocene dichloride as well as a POM compound. These studies might provide starting points for the design of metal‐based SARS‐CoV‐2 antiviral agents.

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PtIV- or MoVI-substituted decavanadates inhibit the growth of Mycobacterium smegmatis

Cited by 16 publications

References 50 publications

Polyoxidovanadates [MoVIVV9O28]5- and [H2PtIVVV9O28]5- interact with CHO cell plasma membrane lipids causing aggregation and activation of a G protein-coupled receptor

Polyoxidovanadates [MoVIVV9O28]5- and [H2PtIVVV9O28]5- interact with CHO cell plasma membrane lipids causing aggregation and activation of a G protein-coupled receptor

All‐Inorganic Polyoxometalates Act as Superchaotropic Membrane Carriers

Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PL^pro

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PtIV- or MoVI-substituted decavanadates inhibit the growth of Mycobacterium smegmatis

Cited by 16 publications

References 50 publications

Polyoxidovanadates [MoVIVV9O28]5- and [H2PtIVVV9O28]5- interact with CHO cell plasma membrane lipids causing aggregation and activation of a G protein-coupled receptor

Polyoxidovanadates [MoVIVV9O28]5- and [H2PtIVVV9O28]5- interact with CHO cell plasma membrane lipids causing aggregation and activation of a G protein-coupled receptor

All‐Inorganic Polyoxometalates Act as Superchaotropic Membrane Carriers

Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PLpro

Contact Info

Product

Resources

About

Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PL^pro