PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

Yu, Mingcan; Tyagi, Abdul Malik; Li, Jau‐Yi; Adams, Jonathan; Denning, Timothy L.; Weitzmann, M. Neale; Jones, Rheinallt; Pacifici, Roberto

doi:10.1038/s41467-019-14148-4

Cited by 86 publications

(119 citation statements)

References 62 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…The secretion of inflammatory or osteoclastogenic cytokines of T cells and bone cells was facilitated under long-term PTH administration, such as RANKL, TNF-α, and IL-17, which promoted the bone resorption ( 83 ). PTH induced bone loss via the expansion of intestinal TNF + T and Th17 cells, and the increase in their S1P-receptor-1 mediated egress from the intestine and recruitment to the BM ( 84 ). So targeting the gut microbiota or T cell migration may represent novel therapeutic strategies for PTH-induced osteoporosis.…”

Section: The T Cells In the Regulation Of Various Osteoporosismentioning

confidence: 99%

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

et al. 2020

View full text Add to dashboard Cite

Immune imbalance caused bone loss. Osteoimmunology is emerging as a new interdisciplinary field to explore the shared molecules and interactions between the skeletal and immune systems. In particular, T lymphocytes (T cells) play pivotal roles in the regulation of bone health. However, the roles and mechanisms of T cells in the treatment of osteoporosis are not fully understood. The present review aims to summarize the essential regulatory roles of T cells in the pathophysiology of various cases of osteoporosis and the development of T cell therapy for osteoporosis from osteoimmunology perspective. As T cell-mediated immunomodulation inhibition reduced bone loss, there is an increasing interest in T cell therapy in an attempt to treat osteoporosis. In summary, the T cell therapy may be further pursued as an immunomodulatory strategy for the treatment of osteoporosis, which can provide a novel perspective for drug development in the future.

show abstract

Section: The T Cells In the Regulation Of Various Osteoporosismentioning

confidence: 99%

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Also PTH induced bone loss has been known to depend on T cell activation (Gao et al, 2008[ 53 ]; Tawfeek et al, 2010[ 118 ]), but it was not clear if these T-cells originate in the bone marrow or in the intestine. Only recently, it was shown by Yu et al that bone loss induced by PTH depends on activation of intestinal TNF + and Th17 T cells in response to the gut microbiota and recruitment of these cells to the bone marrow (Yu et al, 2020[ 132 ]). Taken together, increasing evidence attributes the microbiome and metabolites produced by the microbiome, in particular SCFAs, a key regulatory function in bone homeostasis.…”

Section: Pathophysiology Of Osteoporosismentioning

confidence: 99%

Osteoporosis: Pathophysiology and therapeutic options

Föger-Samwald

Dovjak²,

Azizi-Semrad

et al. 2020

EXCLI Journal; 19:Doc1017; ISSN 1611-2156

View full text Add to dashboard Cite

“…Development of the research of gut microbiome involves not only the drug and TCM but also the daily diet of humans. Recently, a rapidly increasing number of studies have indicated the crucial role of the diet for the treatment of disease (Leboeuf et al, 2020;Li et al, 2020b;Moayyedi et al, 2020;Naudin et al, 2020;Yu et al, 2020). In addition, studies about the close relationship between the diet and the intestinal flora have gradually aroused attention, which may offer us some new perspective for disease prevention.…”

Section: Close Relationships Among Diet Gut Microbiome and Health Carementioning

confidence: 99%

Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare

et al. 2020

View full text Add to dashboard Cite

Advances in systems biology, particularly based on the omics approaches, have resulted in a paradigm shift in both traditional Chinese medicine (TCM) and the gut microbiome research. In line with this paradigm shift, the importance of TCM and gut microbiome in healthcare, as well as their interplay, has become clearer. Firstly, we briefly summarize the current status of three topics in this review: microbiome, TCM, and relationship of TCM and microbiome. Second, we focused on TCM's therapeutic effects and gut microbiome's mediation roles, including the relationships among diet, gut microbiome, and health care. Third, we have summarized some databases and tools to help understand the impact of TCM and gut microbiome on diagnosis and treatment at the molecular level. Finally, we introduce the effects of gut microbiome on TCM and host health, with two case studies, one on the metabolic effect of gut microbiome on TCM, and another on cancer treatment. In summary, we have reviewed the current status of the two components of healthcare: TCM and gut microbiome, as well as their concert effects. It is quite clear that as the holobiont, the maintenance of the health status of human would depend heavily on TCM, gut microbiome, and their combined effects.

show abstract

PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

Cited by 86 publications

References 62 publications

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

Osteoporosis: Pathophysiology and therapeutic options

Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare

Contact Info

Product

Resources

About