PTGS2 gene polymorphism -765G>C is associated with coronary artery disease: a meta-analysis

Abstract

ABSTRACT. Previous studies focusing on the association of PTGS2 polymorphism -765G>C with coronary artery disease (CAD) have failed to reach the same conclusion. In the present study, we performed a meta-analysis to systematically summarize the possible association between PTGS2 polymorphism -765G>C and the risk of CAD. We conducted a search of case-control studies on the associations of PTGS2 with susceptibility to CAD in PubMed, EMBASE, and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. CAD risk associated with PTGS2 -765G>C was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95%CI) with the RevMan 5.2 software. Eleven independent case-control studies on PTGS2 -765G>C were included in our meta-analysis. Our results showed that PTGS2 -765G>C was associated with a decreased risk of CAD (OR = 0.66, 95%CI = 0.56-0.79; P < 0.001). This meta-analysis suggests that PTGS2 -765G>C is associated with a decreased risk of CAD.

Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population

“…A meta-analyses of 22 studies including 3,502 CAD patients and 3,071 controls suggested that the angiotensin II receptor, type 1 gene A1166C polymorphism might be a genetic marker for the development of CAD in Chinese populations, especially in the context of studies with northern and older subjects [ 24 , 25 ]. A meta-analyses of 11 studies involving 22,584 subjects showed that PTGS2 -765G/C was associated with a decreased risk of CAD [ 26 ]. A meta-analyses of ten studies with 4,413 patients found that apolipoprotein M T-778C polymorphism was associated with serum lipid levels and the risk of CAD in the Chinese population [ 27 ].…”

Network Pharmacology and Molecular Docking-Based Analysis on Bioactive Anticoronary Heart Disease Compounds in Trichosanthes kirilowii Maxim and Bulbus allii Macrostemi

“…e former, which is structurally expressed in most normal tissues, is a housekeeping enzyme responsible for a variety of physiological functions and is involved in the formation of thromboxane A2. e latter is rarely expressed in normal tissues but is rapidly induced by cytokines and growth factors [29]. COX-2 is involved in angiogenesis, inhibition of apoptosis, and suppression of the immune response, which are closely associated with CHD.…”