PTERYGIUM: Recent trends and perspectives—A review of pathogenesis and current management options

Ginger-Eke, Helen A; Ogbonnaya, Chimdia; Ezisi, Chinyelu Nkemdilim

doi:10.4103/njo.njo_5_18

Cited by 9 publications

(5 citation statements)

References 2 publications

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“…26,27 In the same vain, genetic alterations of proto-oncogenes such as K-RAS (Kirsten-Ras), alterations in the expression of tumour suppressor genes (p53 or p63), elaboration of several cytokines (including growth factors and growth factor receptors) by UV radiation mediated expression and a high prevalence of human papilloma viruses (HPVs) in pterygium tissue samples have been found in association with the development of this lesion. 27 To this end, pterygium may actually represent a proliferative lesion rather than a degenerative lesion. 27 The infective and inflammatory ophthalmic lesion was the 4th most common (9%) indication for ophthalmic biopsies.…”

Section: Discussionmentioning

confidence: 99%

“…27 To this end, pterygium may actually represent a proliferative lesion rather than a degenerative lesion. 27 The infective and inflammatory ophthalmic lesion was the 4th most common (9%) indication for ophthalmic biopsies. Its value falls within the range of inflammatory ophthalmic lesion (6.06 to 24.8%) with respect to the indication for ophthalmic biopsies as reported from previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Histopathological pattern of Orbito-Ocular Lesions, a retrospective hospital-based study spanning 15 years

Kayoma¹,

Imasogie²

2022

Afr H. Sci.

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Background: Many previous studies on orbito-ocular lesions are skewed in favour of the neoplastic lesions in general and the malignant lesions in particular. This, therefore, creates a vacuum on the spectrum of these lesions, thus may result in problematic diagnostic bias by the ophthalmologist and pathologist. Objective: To give the spectrum and relative frequencies of orbito-ocular biopsies and by extension orbito-ocular lesions/diseases at the University of Benin Teaching Hospital (UBTH). Materials and Methods: A retrospective descriptive study of all cases of orbito-ocular biopsies with histopathologic diagnosis. Results: There were 236 orbito-ocular biopsies. The male to female ratio was slightly in favour of the females. Orbito-ocular biopsies had a wide age range that spanned from the 1st to 10th decade, mean age in the 3rd decade (20-29years) and a peak age in the 1st decade (0-9 years). The neoplastic lesions were the prevalent indication for orbito-ocular biopsies (63.72%) while theconjunctiva (58.10%) was the most common site for orbito-ocular biopsies. Conclusion: This study noted a wide array of orbito-ocular lesions for which biopsies were done for histopathological diagnosis. This we hope will in no small measure increase the diagnostic precision of the ophthalmologist and the pathologists in our own environment. Keywords: Ophthalmic biopsies; ophthalmic lesions; malignant orbito-ocular tumours; benign orbito-ocular tumours; degenerative ophthalmic lesion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histopathological pattern of Orbito-Ocular Lesions, a retrospective hospital-based study spanning 15 years

Kayoma¹,

Imasogie²

2022

Afr H. Sci.

View full text Add to dashboard Cite

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“…Multiple studies have addressed the effect of UVB on limbal cells leading to production of interleukin (IL)-6, IL-8, and growth factors which is linked to inflammation, blood vessel formation, cellular proliferation, and antiapoptosis. [30][31][32] Although the pathogenesis of recurrence due to sunlight has never been well documented, the previously mentioned molecular pathogenesis may possibly apply to any type of pterygium.…”

Section: Discussionmentioning

confidence: 99%

Recurrent pterygium in Bintulu, Sarawak (Malaysian Borneo): determining its risk factors

Murugia

Chong

Lim

et al. 2021

MyJO

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Introduction: Pterygium may give rise to astigmatism in addition to causing blindness in advanced stages, reflecting the importance of timely surgical intervention. Despite various operative approaches, the recurrence rate continues to range from 2% to 89%. Therefore, it is essential to investigate the risk factors influencing recurrence to improve therapeutic strategies. Purpose: To determine the risk factors of pterygium recurrence among the multiethnic cohort of patients in Bintulu, Sarawak (Malaysian Borneo). Study design: Retrospective cohort. Materials and methods: This study was conducted in Bintulu Hospital, Sarawak and involved patients who underwent pterygium excision with conjunctival autografting between April 1, 2016 and May 31, 2019. Patients completed at least a year of follow-up for recurrence detection. Collected data included presence of recurrence, sociodemographics, outdoor activities, habits, first-degree family history, pterygium type and location, as well as laterality. Chi-squared test, Fisher’s exact test, and logistic regression analysis were used. Results: A total of 161 eyes that underwent pterygium excision in 137 patients were identified. Percentage of recurrence was 42%. Mean age during excision was 59.3 ± 11.5 years; age group showed no significance in pterygium recurrence (p = 0.447). Male gender showed statistical significance (p = 0.045, OR 1.90, CI 1.01, 3.58) in chi-squared test but not in logistic regression. Ethnicity, marital status, income, and education level showed no association with recurrence (p > 0.05). Anatomic factors like location (p = 0.353) and laterality (p = 0.955) also showed no association. Smoking (p = 0.867) and alcohol intake (p = 0.397) were insignificant, similar to first-degree family history (p = 0.137). Activities involving sun exposure (p < 0.001, OR 18.34, 95% CI 5.59, 60.17) and recurrent pterygium type (p = 0.001, OR 7.40, 95% CI 1.81, 30.21) supported a positive association with recurrence. Medication adherence (p < 0.001, OR 3.61, 95% CI 1.07, 12.21) and the use of sun protection (p < 0.001, OR 7.90, 95% CI 3.25, 19.19) showed a statistically significant decrease in recurrence. Conclusion: Activities involving sun exposure, use of sun protection, medication adherence, and recurrent pterygium type have shown to be statistically significant in influencing pterygium recurrence.

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“…The bulbar conjunctiva may become increasingly taut as the pterygium enlarges toward the limbus. [6] Symptoms of burning sensation, irritation, lacrimation, and foreign body sensation may accompany the growth of a pterygium onto the cornea. Significant astigmatism may be induced as sectoral corneal steepening occurs.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Tear Production among Adults with Pterygium

2022

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Pterygium is a wing-shaped fibrovascular proliferation that develops over the conjunctiva. This study was carried out to compare the tear production among adult patients with pterygium and a control group. A total of 92 subjects were used for this study which comprised of 52 pterygium subjects and 40 control groups. The tear film production was measured using Schirmer’s test strips and the length of pterygium was measured using PD rule. Visual acuity and external examination were taken on all subjects before tear production measurement. Results showed that for pterygium subjects, tear production of 0-10mm had the highest frequency of 35(67.31%) followed by 11 – 20mm with the frequency of 15(28.85%) and 21 – 30mm with the least frequency of 2(3.85%). For control subjects, tear production of 11 – 20mm had the highest frequency of 24(60%) followed by 21 – 30mm with the frequency of 7(1.75%), 0 – 10mm with frequency of 6(15%) and 31 – 40mm with the least frequency of 3(7.5%). The mean tear production values of pterygium and control subjects were 10.40±5.65mm and 17.65±7.83mm respectively. SPSS version 23 data analysis using the independent sample T-test at 0.05 level of significance showed a significant reduction (P ˂ 0.05) in tear production among pterygium subjects. It was concluded that people with pterygium are more susceptible to dry eye. Public awareness of pterygium and the use of lubricating eye drops were recommended. Keywords: Pterygium, Dry Eye, Tears, Tear film, Tear production, Conjunctiva.

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PTERYGIUM: Recent trends and perspectives—A review of pathogenesis and current management options

Cited by 9 publications

References 2 publications

Histopathological pattern of Orbito-Ocular Lesions, a retrospective hospital-based study spanning 15 years

Histopathological pattern of Orbito-Ocular Lesions, a retrospective hospital-based study spanning 15 years

Recurrent pterygium in Bintulu, Sarawak (Malaysian Borneo): determining its risk factors

Assessment of Tear Production among Adults with Pterygium

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