Pterygium and Associated Ocular Surface Squamous Neoplasia

Hirst, Lawrence W.; Axelsen, Roy A.; Schwab, Ivan R.

doi:10.1001/archophthalmol.2008.531

Cited by 99 publications

(33 citation statements)

References 7 publications

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“…According to these findings showing the function of SDF-1 axis in angiogenesis and the fact that angiogenesis plays important roles in the growth of a pterygium, 3 overexpression of SDF-1, CXCR4 and CXCR7 in our pterygium samples compared to control group probably has crucial roles in the pathogenesis of pterygium. It should be noted that interaction of SDF-1 with CXCR4 or CXCR7 leads to different downstream events 33, 34, 35.…”

Section: Discussionsupporting

confidence: 55%

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Stromal cell derived factor-1, CXCR4 and CXCR7 gene transcripts in pterygia

Bamdad

Khademi

Chenari

et al. 2017

Journal of Current Ophthalmology

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PurposePterygium is a pathologic process with angiogenic and tumor cell like characteristics. Chemokine and chemokine receptors may contribute to the formation and growth of pterygia. The aim of this study was to assess the expression of stromal cell derived factor (SDF)-1, as an angiogenic chemokine, and its receptors, CXCR4 and CXCR7, gene transcripts in pterygia.MethodsRNA was extracted from tissue samples of 33 patients with primary pterygium and 35 volunteers with conjunctiva as the control group. Then the mRNA expression of SDF-1, CXCR4, and CXCR7 was assessed through quantitative Real Time PCR method using appropriate primers.ResultsSDF-1 and both receptors transcripts had significantly higher expression in pterygia samples compared to the control group (P < 0.05). The ratio of CXCR7 transcript expression to CXCR4 was 26.4 in patients while it was 11 in controls.ConclusionAs SDF-1 and its receptors, CXCR4 and CXCR7, were up-regulated in pterygia, SDF-1/CXCR4/CXCR7 axis may contribute to pterygium formation which can be possibly restrained by down-regulating this signaling pathway.

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Section: Discussionsupporting

confidence: 55%

“…Pterygia and ocular surface squamous neoplasia (OSSN) have shared risk factors and may simultaneously occur in a person. The highest rate of OSSN, 9.8% in patients with pterygium after excision, was reported in Australia 3, 4. In contrast, Yeung et al found no case of OSSN in 1127 pterygium specimens 1 …”

Section: Introductionmentioning

confidence: 98%

Stromal cell derived factor-1, CXCR4 and CXCR7 gene transcripts in pterygia

Bamdad

Khademi

Chenari

et al. 2017

Journal of Current Ophthalmology

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“…The condition is associated with chronic ultraviolet radiation exposure and is characterized by induction of cell proliferation, squamous metaplasia, goblet cell hyperplasia, inflammation, fibrosis, angiogenesis, and extracellular matrix breakdown (Chui et al, 2008). Recent studies also provide evidence that pterygium is a stem cell disorder with premalignant features (Chui et al, 2011; Hirst et al, 2009), and that epithelial-mesenchymal transition (EMT) may play a key role in the pathogenesis (Ando et al, 2011; Kato et al, 2007b). Although considerable progress has been made towards understanding the etiology of the disease, the pathogenesis of pterygium is not completely understood (Bradley et al, 2008; Chui et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial–mesenchymal transition in pterygium

Engelsvold

Utheim

Olstad

et al. 2013

Experimental Eye Research

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The current study investigates whether microRNA (miRNA) regulators of epithelial-mesenchymal transition (EMT), tissue fibrosis, and angiogenesis are differentially expressed in human primary pterygium. Genome-wide miRNA and mRNA expression profiling of paired pterygium and normal conjunctiva was performed in the context of conventional excision of pterygium with autotransplantation of conjunctiva (n=8). Quantitative real time polymerase chain reaction (qRT-PCR) was used to validate the expression of key molecules previously detected by microarray. In pterygium, 25 miRNAs and 31 mRNAs were significantly differentially expressed by more than two-fold compared to normal conjunctiva. 14 miRNAs were up-regulated (miR-1246, −486, −451, −3172, −3175, −1308, −1972, −143, −211, −665, −1973, −18a, 143, and −663b), whereas 11 were down-regulated (miR-675, −200b-star, −200a-star, −29b, −200b, −210, −141, −31, −200a, −934, and −375). Unsupervised hierarchical cluster analysis demonstrated that members of the miR-200 family were coexpressed and down-regulated in pterygium. The molecular and cellular functions that were most significant to the miRNA data sets were cellular development, cellular growth and proliferation, and cellular movement. qRT-PCR confirmed the expression of 15 of the 16 genes tested and revealed that miR-429 was down-regulated by more than two-fold in pterygium. The concerted down-regulation of four members from both clusters of the miR-200 family (miR-200a/−200b/−429 and miR-200c/−141), which are known to regulate EMT, and up-regulation of the predicted target and mesenchymal marker fibronectin (FN1), suggest that EMT could potentially play a role in the pathogenesis of pterygium and might constitute promising new targets for therapeutic intervention in pterygium.

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“…Furthermore, pterygium and OSSN can coexist, and several studies have implicated pterygium's origin as a stem cell disorder with premalignant features [19]. The rate of OSSN presence in excised pterygia specimens has been studied in several different countries with results ranging from 0 to 9.8% [20,21,22,23]. The presence of an unexpected OSSN with pterygium is a dilemma because of the vastly contrasting management procedures for pterygium and OSSN.…”

Section: Introductionmentioning

confidence: 99%

“…Most surgeons prefer simple surgical excision, with or without intraoperative mitomycin C application. The use of mitomycin C is helpful in reducing recurrence of pterygia and in the treatment of undetected OSSN [22]. …”

Section: Introductionmentioning

confidence: 99%

Conjunctival Squamous Cell Carcinoma with Corneal Stromal Invasion in Presumed Pterygia: A Case Series

Mendoza¹,

Craven

et al. 2018

Ocul Oncol Pathol

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Aim: To describe 4 cases of conjunctival squamous cell carcinoma (SCC) with corneal stromal invasion. Methods: Retrospective, clinicopathologic case series. Results: All patients had prior resections of presumed pterygia. The degree of corneal involvement dictated the extent of surgical management. One eye with localized invasion was treated with lamellar keratoplasty and plaque brachytherapy. Another case with widespread invasion warranted penetrating keratoplasty and eventual enucleation. Two cases were treated medically prior to surgical intervention: one with localized invasion was treated with topical interferon and retinoic acid; another with significant inflammation was treated with doxycycline and fluorometholone. The patient who underwent keratoplasty and brachytherapy had no recurrence after 7 years of follow-up. Those initially treated medically had resections of recurrence but ultimately required enucleation. Histologically, specimens demonstrated SCC invading the deep corneal stroma, with 2 tumors of the mucoepidermoid type. Conclusions: This series demonstrates the importance of maintaining clinical suspicion of conjunctival squamous neoplasia in pterygia. We recommend that all excised pterygia be submitted for histopathologic evaluation and be carefully evaluated for dysplasia and variants of SCC associated with increased risk of intraocular invasion. Undetected ocular surface squamous neoplasia may give rise to potentially vision- and eye-threatening invasive corneal SCC.

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Pterygium and Associated Ocular Surface Squamous Neoplasia

Cited by 99 publications

References 7 publications

Stromal cell derived factor-1, CXCR4 and CXCR7 gene transcripts in pterygia

Stromal cell derived factor-1, CXCR4 and CXCR7 gene transcripts in pterygia

miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial–mesenchymal transition in pterygium

Conjunctival Squamous Cell Carcinoma with Corneal Stromal Invasion in Presumed Pterygia: A Case Series

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