Pterostilbene influences glycemia and lipidemia and enhances antioxidant status in the liver of rats that consumed sucrose solution

Morais, Juliana Maria Bitencourt de; Cruz, Ellen Mayara Souza; Rosa, Carlos Vinícius Dalto da; Cesário, Roberta Carvalho; Comar, Jurandir Fernando; Moreira, Carolina Campos Lima; Chuffa, Luiz Gustavo de Almeida; Seiva, Fábio Rodrigues Ferreira

doi:10.1016/j.lfs.2021.119048

Cited by 11 publications

(2 citation statements)

References 70 publications

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“…Pterostilbene (3,5-dimethoxy-4 -hydroxystilbene, PTB) is a natural phytoalexin occurring primarily in fruits, such as grapes and blueberries, and in Pterocarpus marsupium heartwood, belonging to Class II of the BCS [9]. PTB has attracted increasing interest, due to its therapeutic properties in several human diseases, which include neurological [10] and metabolic [11,12] disorders. In addition, it has been reported that it possesses antioxidant activity by scavenging reactive oxygen species (ROS) [13], anti-inflammatory activity by reducing the expression of some inflammatory mediators [14], as well as anti-cancer activities by inhibiting and/or preventing the activation of many signaling pathways involved in carcinogenesis [14,15].…”

Section: Introductionmentioning

confidence: 99%

Native Cyclodextrins as Complexation Agents for Pterostilbene: Complex Preparation and Characterization in Solution and in the Solid State

et al. 2021

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Pterostilbene (3,5-dimethoxy-4′-hydroxystilbene, PTB) is a natural dietary stilbene, occurring primarily in blueberries and Pterocarpus marsupium heartwood. The interest in this compound is related to its different biological and pharmacological properties, such as its antioxidant, anti-inflammatory, and anticarcinogenic activities and its capacity to reduce and regulate cholesterol and blood sugar levels. Nevertheless, its use in therapy is hindered by its low aqueous solubility; to overcome this limitation we studied the feasibility of the use of cyclodextrins (CDs) as solubility-enhancing agents. CDs are natural macrocyclic oligomers composed of α-d-glucose units linked by α-1,4 glycosidic bonds to form torus-shaped molecules, responsible for inclusion complex formation with organic molecules. In particular, the aim of this study was to evaluate the feasibility of complexation between PTB and native CDs using various preparative methods. The isolated solid products were characterized using differential scanning calorimetry (DSC), simultaneous thermogravimetric/DSC analysis (TGA/DSC), Fourier transform infrared (FT-IR) spectroscopy, and X-ray diffraction (XRD) on powder and single crystals. The results indicated little or no evidence of the affinity of PTB to complex with α-CD using the kneading method. However, with β-CD and γ-CD thermal analysis revealed an interaction which was also corroborated by FT-IR and 1H-NMR spectroscopy. With β-CD, a hydrated complex of PTB was isolated and its characterization by single-crystal XRD revealed, for the first time, the mode of inclusion of the PTB molecule in the cavity of a CD. To complement the solid-state data, liquid-phase studies were carried out to establish the effect of CDs on the aqueous solubility of PTB and to determine the complex stoichiometries and the association constants for complex formation. Phase-solubility studies showed AL-type profiles for α- and β-CD and a BS profile for γ-CD, with K1:1 values of 1144, 4950, and 133 M−1 for α-CD·PTB, β-CD·PTB, and γ-CD·PTB, respectively. The stoichiometry of CD·PTB complexes, determined by Job’s method, revealed for each system a 1:1 molar ratio. The dissolution rate of PTB was approximately doubled just by employing simple physical mixtures, but the best performance was achieved by products obtained via kneading and co-precipitation, which effected the complete dissolution of PTB in 40 and 20 min for β-CD and γ-CD, respectively.

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Section: Introductionmentioning

confidence: 99%

Native Cyclodextrins as Complexation Agents for Pterostilbene: Complex Preparation and Characterization in Solution and in the Solid State

et al. 2021

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“…At the conclusion of the study, rabbits were kept fasted overnight, then they were euthanized using ketamine (HIKMA Pharmaceuticals, 3310), using (66 mg/kg), and xylazine (Alfasan, 1004111-07), sing (6 mg/kg), via intramuscular injection. 12,13 Following euthanasia, thoracotomy was performed to expose the heart and collect blood. Aortic arch was dissected, and samples collected as well as the following:…”

Section: Induction Of Atherosclerosismentioning

confidence: 99%

Comparing the effectiveness of pterostilbene and sitagliptin on modulating inflammatory levels and inducing autophagy to improve atherosclerosis outcome: A preclinical study in rabbits

et al. 2023

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Background: Inflammation is the key contributor to the development of atherosclerotic plague. This study aims to evaluate the protective and autophagy induction properties of pterostilbene and sitagliptin on modulating the degree of atherosclerosis in rabbit models treated with an atherogenic diet. Methods: 80 rabbits were randomly placed into one of four study groups (20 in each group): normal control diet (NC) fed normal diet for eight weeks, atherogenic control (AC) fed atherogenic diet for eight weeks, pterostilbene treated group (PT) fed atherogenic diet with pterostilbene (at 10 mg/kg/day) orally daily for eight weeks, and sitagliptin treated group (ST) fed atherogenic diet with sitagliptin (at 12 mg/kg/day) orally daily for eight weeks. Results: While serum lipids and F2-isoprostane were elevated significantly in the AC study cohort compared to NC study cohort, (P < 0.001), both pterostilbene and sitagliptin supplementations provided significant improvements in serum lipid parameters and F2-isoprostane in the PT study cohort and ST study cohort, respectively, when compared to the AC study cohort, (P<0.001). Total cholesterol, triglycerides and LDL levels were significantly reduced among the PT and ST study cohorts as compared to the AC study cohort. This was coupled with a significant rise in LC3B levels (marker of tissue autophagy) among the PT study cohort and the ST study cohort, as compared to the AC study cohort, (P < 0.001). The RNA expression of mTORC1 was reduced significantly at both PT study cohort and ST study cohort, (P<0.001). Pterostilbene supplementation induced a significant reduction in tissue expression of PI3K and AKT, (P<0.01), while sitagliptin induced significant reduction in 5’ adenosine monophosphate-activated protein kinase (AMPK) levels, (P<0.001). Conclusions: The results indicate that pterostilbene and/or sitagliptin supplementation can significantly improve the outcome of atherosclerosis due to their effects on the inflammatory pathways which hinder the progression of atherosclerotic plaque formation.

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A Glimpse of necroptosis and diseases

Yang¹,

Chen²,

He³

et al. 2022

Biomedicine & Pharmacotherapy

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Pterostilbene influences glycemia and lipidemia and enhances antioxidant status in the liver of rats that consumed sucrose solution

Cited by 11 publications

References 70 publications

Native Cyclodextrins as Complexation Agents for Pterostilbene: Complex Preparation and Characterization in Solution and in the Solid State

Native Cyclodextrins as Complexation Agents for Pterostilbene: Complex Preparation and Characterization in Solution and in the Solid State

Comparing the effectiveness of pterostilbene and sitagliptin on modulating inflammatory levels and inducing autophagy to improve atherosclerosis outcome: A preclinical study in rabbits

A Glimpse of necroptosis and diseases

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