Pterostilbene and 3′-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells

Tolomeo, Manlio; Grimaudo, Stefania; Cristina, Antonietta Di; Roberti, Marinella; Pizzirani, Daniela; Meli, Maria; Dusonchet, Luisa; Gebbia, Nicola; Abbadessa, Vincenzo; Crosta, Lucia; Barucchello, Riccardo; Grisolia, Giuseppina; Invidiata, Francesco Paolo; Daniele, Simona

doi:10.1016/j.biocel.2005.03.004

Cited by 141 publications

(136 citation statements)

References 39 publications

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“…Previously we have described the synthesis of new cis-and trans-resveratrol based derivatives with the aim of discovering new lead compounds with anticancer potential (Roberti et al, 2003;Tolomeo et al, 2005). In this work we investigated the anti-leishmania activity of some of them, with the aim of discovering new lead candidates or tools for the discovery of new therapeutically relevant targets.…”

Section: Discussionmentioning

confidence: 99%

“…We have also demonstrated that pterostilbene 3 and 3 0 -hydroxy pterostilbene 4 possess interesting antileukemic properties and may constitute effective and powerful drugs in MDR and apoptosis-resistant hematological malignancies. Notably, the toxicity of these compounds, evaluated on normal hemopoietic cells (CFU-GM), was very low (Tolomeo et al, 2005;Cao et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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TTAS a new stilbene derivative that induces apoptosis in Leishmania infantum

Tolomeo

Roberti

Scapozza

et al. 2013

Experimental Parasitology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TTAS a new stilbene derivative that induces apoptosis in Leishmania infantum

Tolomeo

Roberti

Scapozza

et al. 2013

Experimental Parasitology

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“…For instance, 3,5-O-methylated stilbenes [pterostilbene (2l; Fig. 5) and 3-hydroxypetrostilbene] are better apoptosis-inducing agents towards several tumor cells [50,51] (Fig. 5).…”

Section: -2 Production Of Stilbene Methyl Ethersmentioning

confidence: 99%

Combinatorial Biosynthesis of Non-bacterial and Unnatural Flavonoids, Stilbenoids and Curcuminoids by Microorganisms

Horinouchi

2008

J Antibiot

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One of the approaches of combinatorial biosynthesis is combining genes from different organisms and designing a new set of gene clusters to produce bioactive compounds, leading to diversification of both chemical and natural product libraries. This makes efficient use of the potential of the host organisms, especially when microorganisms are used. An Escherichia coli system, in which artificial biosynthetic pathways for production of plant-specific medicinal polyketides, such as flavonoids, stilbenoids, isoflavonoids, and curcuminoids, are assembled, has been designed and expressed. Starting with amino acids tyrosine and phenylalanine as substrates, this system yields naringenin, resveratrol, genistein, and curcumin, for example, all of which are beneficial to human health because of their wide variety of biological activities. Supplementation of unnatural carboxylic acids to the recombinant E. coli cells carrying the artificial pathways by precursor-directed biosynthesis results in production of unnatural compounds. Addition of decorating or modification enzymes to the artificial pathway leads to production of natural and unnatural flavonols, flavones, and methylated resveratrols. This microbial system is promising for construction of larger libraries by employing other polyketide synthases and decorating enzymes of various origins. In addition, the concept of building and expressing artificial biosynthetic pathways for production of non-bacterial and unnatural compounds in microorganisms should be successfully applied to production of not only plant-specific polyketides but also many other useful compound classes.

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“…RES also exhibits antimicrobial activity [10]. Other stilbene compounds, namely trans-piceatannol (PIC) and transpterostilbene (TPS), have also been reported to exhibit chemopreventive, antiinflammatory and antioxidant properties [11][12][13][14]. Growth inhibition or apoptosis has been observed in diverse cell types such as lymphocytes, melanocytes, epidermoid cells, and colon cells treated in vitro with stilbenes such as PIC, RES, or TPS [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…PIC, a metabolite of RES, has been reported to induce apoptosis of transformed and primary lymphocytes [17] and to also exhibit cytotoxic actions towards macrophages in vitro [24]. TPS has been found to possess strong apoptosis-inducing properties in leukemia cell lines but not in normal hematopoietic stem cells [14]. Despite these interesting studies, the cytotoxicity of stilbenes such as RES, TPS, and PIC on cells of the immune system, particularly the macrophages, remains to be fully defined.…”

Section: Introductionmentioning

confidence: 99%

In Vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs

Billack¹,

Radkar²,

Adiabouah³

2008

Cellular and Molecular Biology Letters

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Resveratrol (RES), a component of red wine, possesses antiinflammatory properties. The studies described in the present work were aimed at evaluating the potential for RES and related stilbene analogs (piceatannol, PIC; pterostilbene, TPS; trans-stilbene, TS; and trans-stilbene oxide, TSO) to exhibit toxicity towards RAW 264.7 mouse macrophages. The effect of TS, TSO, RES and TPS on RAW 264.7 macrophage viability was determined by two standard methods: (a) the MTT assay and (b) the trypan blue dye exclusion test. Whereas macrophages were more sensitive to PIC (LC 50 trypan ~ 1.3 μM) and to TPS (LC 50 trypan ~ 4.0 μM and LC 50 MTT ~ 8.3 μM) than to RES (LC 50 trypan ~ 8.9 μM and LC 50 MTT ~ 29.0 μM), they were relatively resistant to TSO (LC 50 trypan ~ 61.0 μM and LC 50 MTT > 100 μM) and to TS (LC 50 trypan ≥ 5.0 μM and LC 50 MTT ≥ 5.0 μM). The ability of selected stilbenes (RES, TPS and PIC) to exhibit growth inhibitory effects was also examined. Although RES and TPS were observed to inhibit cell proliferation in macrophages (IC 50 ≤ 25 µM), these cells were resistant to growth inhibition by PIC (IC 50 ≥ 50 µM). The data obtained in the present analysis demonstrate that substituted stilbene compounds such as RES have the capacity to exhibit cytotoxic and anti-proliferative activities in macrophages.

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Pterostilbene and 3′-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells

Cited by 141 publications

References 39 publications

TTAS a new stilbene derivative that induces apoptosis in Leishmania infantum

TTAS a new stilbene derivative that induces apoptosis in Leishmania infantum

Combinatorial Biosynthesis of Non-bacterial and Unnatural Flavonoids, Stilbenoids and Curcuminoids by Microorganisms

In Vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs

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