Pterospermum acerifolium (L.) wild bark extract induces anticarcinogenic effect in human cancer cells through mitochondrial-mediated ROS generation

Tripathi, Surya Kant; Biswal, Bijesh K.

doi:10.1007/s11033-018-4390-6

Cited by 12 publications

(5 citation statements)

References 35 publications

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“…The most striking feature of polyphenols is undoubtedly their ability to capture reactive oxygen species (ROS), which include both radical and non-radical oxygen species, as well as oxidative free radicals derived from biomolecules, such as low-density lipoproteins (LDL), proteins and oligonucleic acids [32]. This antioxidant ability is frequently associated to the property underlying the prevention and/or reduction of oxidative stressrelated diseases [33][34][35], such as diabetes [30]; cardiovascular diseases [36], neurodegeneration [5], inflammation [33] and carcinogenesis [37][38][39][40]. It is known that cancer is characterized by sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis [41].…”

Section: Discussionmentioning

confidence: 99%

Luehea candicans Increase In Vitro Cell Cancer Metabolism Even with High Polyphenols Content

Camara¹,

Rabêlo²,

Borghesi³

et al. 2019

Med Aromat Plants

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Brazil is the country with the greatest biodiversity; however, most of the plants are used empirically, without scientific evidence. Luehea candicans, popularly called as-açoita-cavalo, is a specie characteristic of the Brazilian Cerrado Biome, used for fight hemorrhages, dysenteries, diarrhea, rheumatism and tumors. On the other hands, there are practically no studies about chemical composition and assess of their biological effects. Thus, the aim of this investigation was characterize and evaluate the antitumor potential of crude hydroethanolic extract from the bare stem parts of this plant, as well as its ethyl acetate and methanolic fractions. For the characterization, the crude extract was submitted to qualitative (phytochemical screening and analysis by direct flow injection by mass spectrometry-FIA-ESI-IT-MS) and quantitative tests (determination of phenolic compounds and determination of total flavonoids and anthocyanins).In order to study the antitumor potential, MTT technique was used to evaluate the cellular metabolism of canine breast cancer tumor cells (TCM) and osteosarcoma (OST). The results demonstrated the presence of polyphenols, mainly flavonoids and tannins. In addition, were observed an increase in metabolism when TCM and OST cells were incubated with all extracts of L candicans. Based on this, L candicans in these tumor types should be careful use, and that in vivo studies should be performed to prove the true effects of this plant.

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Section: Discussionmentioning

confidence: 99%

Luehea candicans Increase In Vitro Cell Cancer Metabolism Even with High Polyphenols Content

Camara¹,

Rabêlo²,

Borghesi³

et al. 2019

Med Aromat Plants

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“…Pterospermum acerifolium ethanolic bark extract induced apoptosis and cytotoxic effect in PANC-1 cells by up-regulating mitochondrial-mediated ROS production [61]. P. acerifolium bark extract also showed apoptosis against lung cancer cells (A549).…”

Section: Plants Extractsmentioning

confidence: 96%

“…In in vitro experiments, fifteen substances, 8-Chrysoeriol, elemene, mastic gum resin, RN1, bitter apricot ethanolic extract (BAEE), coix seed emulsion, Eucalyptus microcorys aqueous extract, Eucalyptus microcorys leaf ethanolic extract, Eucalyptus microcorys fruit aqueous extract, Eucalyptus saligna ethanolic extract, Moringa aqueous leaf extract, Paeonia suffruticosa aqueous extracts (PS), Salvia chinensis polyphenol-rich extract, Pterospermum acerifolium ethanolic bark extract (PaEBE), and Sedum sarmentosum Bunge, extract were conducted at a high concentration of 60 µg/mL or higher [31,36,42,46,53,56,[59][60][61][62][63]. In such cases, when applied to humans, the amount of medicine could be far abundant, which requires attention.…”

Section: Formulationsmentioning

confidence: 99%

“…However, not all researches had in vivo studies, but 17 were effective in a mice model [24,27,33,34,36,40,[43][44][45][46]50,53,54,57,59,60,63,65]. Fifteen substances were administrated at a high concentration of 60 µg/mL or higher, which demands attention when applied to humans [31,36,42,46,51,53,55,56,[59][60][61][62][63]. Twenty substances conducted cytotoxicity experiments [24,26,29,30,36,38,[41][42][43][44]46,[49][50][51]53,55,62].…”

Section: Anti-cancer Mechanisms Of Natural Productsmentioning

confidence: 99%

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Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery

Kim

et al. 2021

Nutrients

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Pancreatic cancer, the seventh most lethal cancer around the world, is considered complicated cancer due to poor prognosis and difficulty in treatment. Despite all the conventional treatments, including surgical therapy and chemotherapy, the mortality rate is still high. Therefore, the possibility of using natural products for pancreatic cancer is increasing. In this study, 68 natural products that have anti-pancreatic cancer effects reported within five years were reviewed. The mechanisms of anti-cancer effects were divided into four types: apoptosis, anti-metastasis, anti-angiogenesis, and anti-resistance. Most of the studies were conducted for natural products that induce apoptosis in pancreatic cancer. Among them, plant extracts such as Eucalyptus microcorys account for the major portion. Some natural products, including Moringa, Coix seed, etc., showed multi-functional properties. Natural products could be beneficial candidates for treating pancreatic cancer.

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“…Several studies found that the accumulation of ROS decreases mitochondrial membrane potential (MMP) and mitochondria depolarization. The presence of ROS leads to cell cycle arrest at the G2/M phase, followed by the accumulation of DNA damage and induction of apoptosis [ 102 , 103 ]. Other researchers reported that marine extracts from nudibranchs, brown algae, and Arctic fungi trigger the intracellular accumulation of ROS in cancer cells originated from human CRC and PC, leading to apoptosis [ 36 , 58 , 61 ].…”

Section: Mechanisms Of Action Of Mnps In Crc and Pcmentioning

confidence: 99%

Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential

Amer

Knaan

2022

IJMS

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Gastrointestinal cancer refers to malignancy of the accessory organs of digestion, and it includes colorectal cancer (CRC) and pancreatic cancer (PC). Worldwide, CRC is the second most common cancer among women and the third most common among men. PC has a poor prognosis and high mortality, with 5-year relative survival of approximately 11.5%. Conventional chemotherapy treatments for these cancers are limited due to severe side effects and the development of drug resistance. Therefore, there is an urgent need to develop new and safe drugs for effective treatment of PC and CRC. Historically, natural sources—plants in particular—have played a dominant role in traditional medicine used to treat a wide spectrum of diseases. In recent decades, marine natural products (MNPs) have shown great potential as drugs, but drug leads for treating various types of cancer, including CRC and PC, are scarce. To date, marine-based drugs have been used against leukemia, metastatic breast cancer, soft tissue sarcoma, and ovarian cancer. In this review, we summarized existing studies describing MNPs that were found to have an effect on CRC and PC, and we discussed the potential mechanisms of action of MNPs as well as future prospects for their use in treating these cancers.

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Pterospermum acerifolium (L.) wild bark extract induces anticarcinogenic effect in human cancer cells through mitochondrial-mediated ROS generation

Cited by 12 publications

References 35 publications

Luehea candicans Increase In Vitro Cell Cancer Metabolism Even with High Polyphenols Content

Luehea candicans Increase In Vitro Cell Cancer Metabolism Even with High Polyphenols Content

Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery

Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential

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