Pterin Chemistry, Part 91. Synthesis and Crystal Structure of the First Molybdenum (IV)-q-dihydro-L-Biopterin Complex

Abstract

Fischer et al.\ Synthesis and crystal structure of the first molybdenum (IV)-q-L-biopterin complex

Functional and Structural Model for the Molybdenum-Pterin Binding Site in Dimethyl Sulfoxide Reductase. Synthesis, Crystal Structure, and Spectroscopic Investigations of Trichloro(quinoid-N(8)H-6,7-dihydropterin)oxomolybdenum(IV)

“…This structure prompted us, supported by spectroscopical data, to propose a participation of the pterin nucleus in the enzyme reaction of molybdenum dependent oxidoreductases and to formulate a model of an extended molybdenum cofactor in its reduced form (Figure 2). 32 40 In this paper a new molybdenum-quinonoid-dihydropterin complex and its structural and spectroscopical characterization are described. The complex is able to quantitatively reduce the substrate dimethyl sulfoxide to dimethyl sulfide in the absence of oxygen.…”

New Results on the Chemistry of Metal-Tetrahydro-Pterin Complexes

“…These may act as coenzymes of oxidoreductases in numerous biological reactions (2,3). It is difficult to obtain product 1 in high yields, because 6J3-5,6,7,8-tetrahydro-L-biopterin (BH4) is expensive; therefore we tried to obtain an analogous product with a pterin, that is easier to synthesize in large quantities.…”

Iron and Terahydropterin Complex with 1,3,5-Triamino-2,4,6-trihydroxycydohexane as Ligand

“…During our reaserch on the complexes of tetrahydropterin (THP) or tetrahydrobiopterin (THP) with molybdenum and iron, we used 2,4-dioxo-pentane (acetylacetonate, acacoH), whose chelate properties are well known, as second ligand [1][2][3][4]. During the formation of these complexes, THP or THB occupies two of the six coordination sites of the metal, while two acaco anions occupy the four other, so that an activation of 0, by the nucleus Fe(II) seems rather difficult.…”