Summary1,3-Dimethyl-6-tritluoromethanesultonyloxylumazine is prepared bv a reaction of 1 ,3-dimethvllumazine 5-oxide with tritluoromethanesultonic anhydride and is converted efficiently into lumazines with various substituents, for example amino, halogens, phenylthio, thiocyano, phenylseleno, and so on, on the 6-position by reactions with tlle corresponding nucleophiles.