PTEN loss and p27 loss differ among morphologic patterns of prostate cancer, including cribriform

Ronen, Shira; Abbott, Daniel; Kravtsov, Oleksandr; Abdelkader, Amrou; Xu, Yayun; Banerjee, Anjishnu; Iczkowski, Kenneth A.

doi:10.1016/j.humpath.2017.04.024

Cited by 37 publications

(27 citation statements)

References 28 publications

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“…While reports of PTEN alteration in ductal adenocarcinoma are mixed [11,35], multiple series have reported high rates of PTEN loss [36,37]. Furthermore, PTEN loss is associated with multiple markers of poor prognosis and has recently been associated with cribriform morphology, similar to that of ductal histology [38]. This raises the possibility that ductal features may correlate with response to WNT-or PI3K-pathway-targeted therapy.…”

Section: Discussionmentioning

confidence: 99%

Integrative Genomic Analysis of Coincident Cancer Foci Implicates CTNNB1 and PTEN Alterations in Ductal Prostate Cancer

Gillard

Lack

Pontier

et al. 2019

European Urology Focus

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Section: Discussionmentioning

confidence: 99%

Integrative Genomic Analysis of Coincident Cancer Foci Implicates CTNNB1 and PTEN Alterations in Ductal Prostate Cancer

Gillard

Lack

Pontier

et al. 2019

European Urology Focus

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“…The cyclin kinase inhibitor p27Kip1 is considered as a tumor suppressor that plays a critical role in cell proliferation, differentiation, and apoptosis [35][36][37][38]. Dysregulation of p27Kip1 gene expression at the mRNA or the protein level was reported in various cancers [39,40]. Especially, p27Kip1 has been implicated in tumorigenesis and oncogenic progression of gliomas [41,42].…”

Section: Discussionmentioning

confidence: 99%

EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma

Qiu

Xia³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Accumulating evidence suggests that Eyes Absent Homologue 4 (EYA4) plays an important role in tumorigenesis and progression of various cancers. However, the role of EYA4 in glioma development is still unclear. Methods: The expression of EYA4 was examined in glioma tissues by immunohistochemistry. Cell viability and apoptosis were analyzed by CCK-8, BrdU assay, and flow cytometry. Results: We found that EYA4 was upregulated in glioma, and its expression was positively correlated with advanced tumor stage. Moreover, higher expression of EYA4 predicted a worse overall survival in patients with glioma. Forced overexpression of EYA4 enhanced glioma cell proliferation, and EYA4 suppressed the expression of p27Kip1 directly in these cells. Furthermore, Six1 was required for EYA4 to suppress the expression of p27Kip1 in glioma. Conclusion: Together, we demonstrate that EYA4 promotes cell proliferation by directly suppressing the expression of p27Kip1 in glioma.

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“…PTEN acts as a critical tumor suppressor by inhibiting PI3K pathway [ 27 ]. The inactivation of PTEN by genetic (Loss of heterozygosity, mutations) or epigenetic regulation (promoter hypermethylation, miRNAs) has been found in various tumors [ 29 , 53 – 55 ]. In the present study, we showed that EYA2 could suppress the PTEN expression via modulation of miR-93, which negatively regulated the expression of PTEN by binding to its 3′-UTR directly.…”

Section: Discussionmentioning

confidence: 99%

EYA2 promotes lung cancer cell proliferation by downregulating the expression of PTEN

Qiu

Xia³

et al. 2017

Oncotarget

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Lung cancer is the leading cause of cancer-related death worldwide. Despite advances have been made in diagnosis and therapeutic strategies, the prognosis of lung cancer is still very poor. Eyes absent transcriptional cofactor EYA2 has been shown to promote lung cancer cell growth, however, the underlying molecular mechanism is still not fully understood. In the present study, we found that EYA2 was up-regulated in lung cancer, and EYA2 led to increased cell proliferation by inhibiting Phosphatase and tensin homologue (PTEN) expression via modulation of miR-93. Additionally, survival analysis showed that lung cancer patients with higher EYA2 expression predicted a worse prognosis. Therefore, these findings demonstrate that EYA2 may play an important role in lung cancer occurrence and progression. Targeting EYA2 may provide a feasible approach in developing novel anticancer therapeutics.

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PTEN loss and p27 loss differ among morphologic patterns of prostate cancer, including cribriform

Cited by 37 publications

References 28 publications

Integrative Genomic Analysis of Coincident Cancer Foci Implicates CTNNB1 and PTEN Alterations in Ductal Prostate Cancer

Integrative Genomic Analysis of Coincident Cancer Foci Implicates CTNNB1 and PTEN Alterations in Ductal Prostate Cancer

EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma

EYA2 promotes lung cancer cell proliferation by downregulating the expression of PTEN

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