PTEN inhibition preserves trigeminal nucleus caudalis neuron activation through tyrosine phosphorylation of the NR2B subunit at Tyr1472 of the NMDA receptor in a rat model of recurrent migraine

Abstract

These results suggest that, phosphatase and tensin homolog might be a novel and promising candidate for future treatment or prophylaxis of recurrent migraine by attenuating neuron activation in the trigeminal nucleus caudalis.

PTEN Inhibition in Human Disease Therapy

“…A role for PTEN in regulating hyperalgesia and nociception has been proposed based on the observations that animals from rat and mice models of migraine displayed improved mechanical thresholds and less spinal trigeminal neuron activation upon PTEN knockdown, in association with diminished tyrosine phosphorylation of the of the NMDA receptor NR2B subunit [ 225 , 226 ]. Accordingly, the increased mechanical allodynia shown by rats injected with NMDA was attenuated upon co-injection with bpV(phen), with concomitant decrease in Src-mediated NR2B phosphorylation [ 137 ].…”

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“…Pain Relief or Antinociception: PTEN plays a role in regulating hyperalgesia and nociception has been reported based on the results observed from rats and mouse models of migraine showed an increased mechanical threshold and minimal spinal trigeminal neuron activation upon PTEN knockout, in related with reduced tyrosine phosphorylation of the NMDA receptor 34,35 . Moreover, PTEN has been playing a crucial role in the negative regulation in the sensory of the d opioid analgesic receptor (δR) expression 36 .…”

“…QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.11 (1). [35][36][37][38][39][40] The article can be accessed online on www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.11 (1). [35][36][37][38][39][40] PTEN is a regularly expressed protein, function as a dual function like specific protein phospholipid phosphatase.…”

“…[35][36][37][38][39][40] The article can be accessed online on www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.11 (1). [35][36][37][38][39][40] PTEN is a regularly expressed protein, function as a dual function like specific protein phospholipid phosphatase. It maintains several processes and signals transduction pathway mediated through PtdIns (3,4,5) P3 has been widely considered and it shows a specific function in controlling various physiological and pathological important processes like cell proliferation, motility, cell growth, and survival.…”