Pt3R5G inhibits colon cancer cell proliferation through inducing ferroptosis by down-regulating SLC7A11

Lin, Han; Yan, Yamei; Fan, Meiyang; Gao, Shanfeng; Zhang, Lingyu; Xiong, Xiaofan; Li, Rufeng; Xiao, Xuan; Wang, Xiaofei; Ni, Lei; Tong, Dongdong; Huang, Chen; Cao, Yang; Yang, Juan

doi:10.1016/j.lfs.2022.120859

Cited by 18 publications

(13 citation statements)

References 49 publications

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“…Luteolin is a well-studied tetrahydroxyflavone with hydroxyl groups at positions 3, 4, 5, and 7 (Ntalouka & Tsirivakou, 2023) (Han, Dong, et al, 2022;Han, Li, & Wu, 2022;Han, Lin, et al, 2022;Han, Yan, et al, 2022). Zheng et al…”

Section: Luteolinmentioning

confidence: 99%

“…FA administration distinctly disrupts the ESCC cells' ability to form colonies and triggers apoptosis, as evidenced by heightened caspase-3 activity. Dong, et al, 2022;Han, Li, & Wu, 2022;Han, Lin, et al, 2022;Han, Yan, et al, 2022). ics, capsaicin demonstrates a potential therapeutic strategy in mitigating ferroptotic cell death in non-malignant conditions (Wang, Li, Wang, Chen, & Goh, 2023;Wang, Li, Wang, Zhu, Liu, et al, 2023;Wang, Lin, Huang, Liu, Chen, et al, 2023;Wang, Liu, Li, Zha, Chen, et al, 2023;Wang, Shen, Lian, Deng, Qu, et al, 2023;Wang, Tan, Zhang, Wu, & Shi, 2023;Wang, Wan, Peng, Zhao, Bai, & Hu, 2023).…”

Section: Ferulic Acidmentioning

confidence: 99%

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Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form of regulated cell death characterized by iron‐dependent lipid peroxidation. This review delves into the roles of key natural phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis and their underlying mechanisms. Emphasizing the significance of amino acid, lipid, and iron metabolism, the study elucidates the diverse pathways through which these phenols regulate ferroptosis. Notably, curcumin, a well‐known polyphenol, exhibits multifaceted interactions with cellular components involved in ferroptosis regulation, providing a distinctive therapeutic avenue. Stilbenes, another phenolic class, demonstrate promising potential in influencing lipid metabolism and iron‐dependent processes, contributing to ferroptotic cell death. Understanding the intricate interplay between these natural phenols and ferroptosis not only illuminates complex cellular regulatory networks but also unveils potential avenues for novel cancer therapies. Exploring these compounds as inducers of ferroptosis presents a promising strategy for targeted cancer treatment, capitalizing on the delicate balance between cellular metabolism and regulated cell death mechanisms. This article synthesizes current knowledge, aiming to stimulate further research into the therapeutic potential of natural phenols in the context of ferroptosis‐mediated cancer therapy.

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Section: Luteolinmentioning

confidence: 99%

Section: Ferulic Acidmentioning

confidence: 99%

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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“…Lysionotin (Lys) is a flavonoid compound that promotes the accumulation of ROS in CRC cells and increases the degradation rate of Nrf2 protein, resulting in ferroptosis ( 113 ). Petunidin 3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(β-D-glucopyranoside) (Pt3R5G) further inhibits the proliferation of human colonic adenocarcinoma cells (RKO) primarily by down-regulating SLC7A11 to inhibit ferroptosis ( 114 ). Auriculasin promotes CRC apoptosis, ferroptosis, and oxidative apoptosis by inducing ROS production, thereby inhibiting cell infiltration ( 114 ).…”

Section: Research Status Of Ferroptosis In Crcmentioning

confidence: 99%

“…Petunidin 3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(β-D-glucopyranoside) (Pt3R5G) further inhibits the proliferation of human colonic adenocarcinoma cells (RKO) primarily by down-regulating SLC7A11 to inhibit ferroptosis ( 114 ). Auriculasin promotes CRC apoptosis, ferroptosis, and oxidative apoptosis by inducing ROS production, thereby inhibiting cell infiltration ( 114 ). Double-targeted PI3K and HDAC inhibitor BEBT-908 developed by Fan et al.…”

Section: Research Status Of Ferroptosis In Crcmentioning

confidence: 99%

Ferroptosis open a new door for colorectal cancer treatment

Liang

Tong

et al. 2023

Front. Oncol.

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Colorectal cancer (CRC) is the third highest incidence and the second highest mortality malignant tumor in the world. The etiology and pathogenesis of CRC are complex. Due to the long course of the disease and no obvious early symptoms, most patients are diagnosed as middle and late stages. CRC is prone to metastasis, most commonly liver metastasis, which is one of the leading causes of death in CRC patients. Ferroptosis is a newly discovered cell death form with iron dependence, which is driven by excessive lipid peroxides on the cell membrane. It is different from other form of programmed cell death in morphology and mechanism, such as apoptosis, pyroptosis and necroptosis. Numerous studies have shown that ferroptosis may play an important role in the development of CRC. For advanced or metastatic CRC, ferroptosis promises to open a new door in the setting of poor response to chemotherapy and targeted therapy. This mini review focuses on the pathogenesis of CRC, the mechanism of ferroptosis and the research status of ferroptosis in CRC treatment. The potential association between ferroptosis and CRC and some challenges are discussed.

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“…The fruit, root bark and leaves of Lycium barbarum are widely used as food and pharmaceutical additives [32], and contains rich chemical components [33]. A large number of studies have shown that it has a variety of favorable biological effects in patients with diabetes [32,34], impaired reproductive systems [35,36], eye diseases [37,38], cardiovascular diseases [39,40] and cancers [41,42]. Lycium barbarum polysaccharide (LBP), the main active component of Lycium barbarum, has been shown to possess anti-oxidation, anti-inflammatory, anti-tumor and anti-aging properties [43][44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure

Huang¹,

Zhang²,

Chen³

et al. 2023

Front. Biosci. (Landmark Ed)

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Ischemic stroke and cranial radiotherapy may induce brain inflammatory response, oxidative stress, apoptosis and neuronal loss, and impairment of neurogenesis. Lycium barbarum has anti-oxidation, anti-inflammatory, anti-tumor and anti-aging properties, may produce both neuroprotective and radioprotective effects. In this narrative review paper, we described the neuroprotective effect of Lycium barbarum in different animal models of experimental ischemic stroke and limited studies in irradiated animal models. Relevant molecular mechanisms are also summarized. It has been shown that in experimental ischemic stroke models, Lycium barbarum produces neuroprotective effects by modulating neuroinflammatory factors such as cytokines and chemokines, reactive oxygen species, and neurotransmitter and receptor systems. In irradiation animal models, Lycium barbarum prevents radiation-induced loss of hippocampal interneurons. Given its minimal side-effects, these preclinical studies suggest that Lycium barbarum may be a promising radio-neuro-protective drug that can be used as an adjunct treatment to radiotherapy for brain tumor and in the treatment of ischemic stroke. At molecular levels, Lycium barbarum may regulate PI3K/Akt/GSK-3β, PI3K/Akt/mTOR, PKCε/Nrf2/HO-1, keap1-Nrf2/HO-1, and NR2A and NR2B receptor-related signal transduction pathways to produce neuroprotective effects.

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Pt3R5G inhibits colon cancer cell proliferation through inducing ferroptosis by down-regulating SLC7A11

Cited by 18 publications

References 49 publications

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Ferroptosis open a new door for colorectal cancer treatment

Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure

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