Pt‐doped NiO Nanoparticle‐Ionic Liquid Modified Electrochemical Sensor: A Powerful Approach for Determination of Epinine in the Presence of Phenylephrine as two Blood Pressure Raising Drugs

Abstract

A new and progressive electroanalytical sensor was made by the incorporation of Pt‐doped NiO nanoparticle (Pt‐NiO‐NPs) into carbon paste electrode (CPE) amplified with 1‐hexyl‐3‐methylimidazolium tetrafluoroborate (1H3MTFB) as a conductive binder. The Pt‐NiO‐NPs/1H3MTFB/CPE caused an extraordinary rise in the oxidation peak current of epinine (∼4.6 times) and simultaneous reduction in the oxidation over‐potential of catecholamine drug (∼120 mV). SWV method was employed to investigate the ability of Pt‐NiO‐NPs/1H3MTFB/CPE as an electroanalytical sensor in the determination of epinine in the presence of phenylephrine as two blood pressure raising drugs with ΔE=280 mV for the first time. Experimental results pertinent to SW voltammetric investigation reveal a linear relation between epinine and phenylephrine currents and drugs concentration in the rages 0.004–450 and 0.02–350 μM, respectively.

Synthesis and Characterization of GO/ZIF-67 Nanocomposite: Investigation of Catalytic Activity for the Determination of Epinine in the Presence of Dobutamine

“…Moreover, limit of detection (LOD) and limit of quantification (LOQ) were obtained 2.0 nM and 6.0 nM respectively (S/N = 3). The detection limit was comparable with the obtained values in references [27] (0.2 µM) and [58] (1.0 nM).…”

“…In the next stage, the slope of the final direct line was plotted as the opposed concentration of epinine (Figure 10B). Finally, the diffusion coefficient equaling to 8.6 × 10 −6 cm 2 s −1 was estimated for epinine, which was comparable with values obtained in references [27] (4.0 × 10 −6 cm 2 s −1 ) and [58]…”