Psychotropics and the Microbiome: a Chamber of Secrets…

Cussotto, Sofia; Clarke, Gerard; Dinan, Timothy G.; Cryan, John F.

doi:10.1007/s00213-019-5185-8

Cited by 118 publications

(87 citation statements)

References 168 publications

(250 reference statements)

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“…Due to the limited number of studies evaluating the composition of the gastrointestinal microbiota in our results, the heterogeneity of techniques used, variance in findings, and issues around drug use, it is difficult to draw any firm conclusions regarding microbiome alterations in this patient population. This Pandora's box is of intricate complexity (49), such that meaningful results would possibly be best obtained by studying these factors in a much larger, drug-naïve cohort. To date, no extensive analysis has been undertaken to simultaneously evaluate the composition of the gastrointestinal tract microbiota, its metabolites, luminal neurotransmitters and brain neurochemistry in people with fibromyalgia.…”

Section: Gut Microbiotamentioning

confidence: 99%

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Erdrich

Hawrelak

Myers

et al. 2020

Preprint

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Background The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however, this association is poorly understood in fibromyalgia. Our aim was to summarise the research reporting on the gastrointestinal microbiome and its biomarkers in people with fibromyalgia.Methods A systematic review of published original research reporting on the gastrointestinal microbiota and its biomarkers in adults with a diagnosis of fibromyalgia was undertaken.Results From 4771 studies, 11 met our inclusion criteria and were separated into four main groups: papers reporting Helicobacter pylori ; other gut bacterial markers; metabolomics and other biomarkers, which included intestinal permeability and small intestinal bacterial overgrowth.Conclusion The results suggest there is a paucity of quality research in this area, with indications that the gut microbiota may play a role in fibromyalgia within the emerging field of the gut-musculoskeletal axis. Further investigations into the relationship between the gut microbiota, gut dysfunction and fibromyalgia are warranted.

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Section: Gut Microbiotamentioning

confidence: 99%

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Erdrich

Hawrelak

Myers

et al. 2020

Preprint

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“…It is important to note that the growing evidence suggests the intestinal microbiome could be involved in the treatment response. Moreover, gut microorganisms might be necessary to the occurrence of adverse effects such as weight gain (20).…”

Section: Introductionmentioning

confidence: 99%

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

et al. 2020

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Atypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for schizophrenia treatment during acute psychoses, but they are also indicated for maintenance during lifetime, even though they are being used for other psychiatric conditions in clinical practice such as affective disorders and autism spectrum disorder, among others. These drugs are differentiated from typical antipsychotics based on their clinical profile and are a better choice because they cause fewer side effects regarding extrapyramidal symptoms (EPS). Even though they provide clear therapeutic benefits, AAP induce peripheral effects that trigger phenotypic, functional, and systemic changes outside the Central Nervous System (CNS). Metabolic disease is frequently associated with AAP and significantly impacts the patient's quality of life. However, other peripheral changes of clinical relevance are present during AAP treatment, such as alterations in the immune and endocrine systems as well as the intestinal microbiome. These less studied alterations also have a significant impact in the patient's health status. This manuscript aims to revise the peripheral immunological, endocrine, and intestinal microbiome changes induced by AAP consumption recommended in the clinical guidelines for schizophrenia and other psychiatric disorders.

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“…The pathways and mechanism by which these associations are manifest remain to be fully elucidated. However, recent developments in genome sequencing, metabolomics, functional imaging and computational biology have increased our understanding considerably [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Global research trends in microbiome-gut-brain axis during 2009–2018: a bibliometric and visualized study

et al. 2019

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Background The pathways and mechanism by which associations between the gut microbiome and the brain, termed the microbiome-gut-brain axis (MGBA), are manifest but remain to be fully elucidated. This study aims to use bibliometric analysis to estimate the global activity within this rapidly developing field and to identify particular areas of focus that are of current relevance to the MGBA during the last decade (2009–2018). Methods The current study uses the Scopus for data collection. We used the key terms “microbiome-gut-brain axis” and its synonyms because we are concerned with MGBA per se as a new concept in research rather than related topics. A VOSviewer version 1.6.11 was used to visualize collaboration pattern between countries and authors, and evolving research topics by analysis of the term co-occurrence in the title and abstract of publications. Results Between 2009 and 2018, there were 51,504 published documents related to the microbiome, including 1713 articles related to the MGBA: 829 (48.4%) original articles, 658(38.4%) reviews, and 226 (13.2%) other articles such as notes, editorials or letters. The USA took the first place with 385 appearances, followed by Ireland ( n = 161), China ( n = 155), and Canada ( n = 144).The overall citation h-index was 106, and the countries with the highest h-index values were the USA (69), Ireland (58), and Canada (43). The cluster analysis demonstrated that the dominant fields of the MGBA include four clusters with four research directions: “modeling MGBA in animal systems”, “interplay between the gut microbiota and the immune system”, “irritable bowel syndrome related to gut microbiota”, and “neurodegenerative diseases related to gut microbiota”. Conclusions This study demonstrates that the research on the MGBA has been becoming progressively more extensive at global level over the past 10 years. Overall, our study found that a large amount of work on MGBA focused on immunomodulation, irritable bowel syndrome, and neurodevelopmental disorders. Despite considerable progress illustrating the communication between the gut microbiome and the brain over the past 10 years, many issues remain about their relevance for therapeutic intervention of many diseases.

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Psychotropics and the Microbiome: a Chamber of Secrets…

Cited by 118 publications

References 168 publications

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

Global research trends in microbiome-gut-brain axis during 2009–2018: a bibliometric and visualized study

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