Psychotropic medicine consumption in 65 countries and regions, 2008–19: a longitudinal study

Brauer, Ruth; Alfageh, Basmah H.; Blais, Joseph E; Chan, Esther W.; Chui, Celine S L; Hayes, Joseph F.; Man, Kenneth K C; Lau, Wallis C.Y.; Yan, Vincent Ka Chun; Beykloo, Maedeh Y; Wang, Zixuan; Wei, Li; Wong, Ian C. K.

doi:10.1016/s2215-0366(21)00292-3

Cited by 69 publications

(66 citation statements)

References 35 publications

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“…The argument for underdiagnosis of those mental conditions in Poland is stronger, since while, historically and socially, the countries have many similarities, Poland is one of the better developed economically, suggesting potentially better access to healthcare services. Globally, the use of antidepressants and antianxiety medication is growing, particularly in high income countries [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Between 2008 and 2019, the average consumption per day per 1000 inhabitants in high income countries measured by daily defined dose increased from 51.98 to 72.93, indicating a 40% increase and equivalent to an average compound growth of 3% per year [ 28 ]. According to the data obtained for this study, in January 2018, the DDD consumption for 1000 citizens per day was 32.94 doses; whereas, in October 2021, it was 49.01, representing a 49% increase over a little under three years, rather than 12 years.…”

Section: Discussionmentioning

confidence: 99%

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Impact of COVID-19 Pandemic on the Use of Antidepressant and Antianxiety Pharmaceuticals as Well as Sick Leave in Poland

Krupa

Czech²,

Pinkas

et al. 2022

IJERPH

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The COVID-19 pandemic caused a major upheaval to the lives of people and placed a strain on societal mental health. The aim of this research is to estimate the impact of the pandemic on the mental condition of the Polish population measured through the consumption of relevant medication and medical leave of absence from the workplace. Methods: We analyzed national-level data on the consumption of pharmaceuticals used in clinical practice in Poland in the treatment of depression and anxiety alongside medical absence in the workplace using the Interrupted Time Series model to estimate the significance of the pandemic. Results: We found no significant change regarding the consumption of pharmaceuticals with the development of the pandemic. Conversely, medical leaves of absence for psychiatric reasons increased significantly with the onset of COVID-19. The influence was strongest in the diagnosis of anxiety or reaction to severe stress and weakest in recurrent depression. Conclusion: The pandemic had a significant influence on the ability to work for psychiatric patients in Poland but did not change pharmaceutical use. Physicians should consider the mental health of patients impacted by the anti-epidemic measures. Further study is needed to fully understand the long-term impact of the pandemic on mental health in Poland.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 Pandemic on the Use of Antidepressant and Antianxiety Pharmaceuticals as Well as Sick Leave in Poland

Krupa

Czech²,

Pinkas

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…Three different redox systems were performed to confirm which active radical of all the major radicals generated during water radiolysis played a leading role in the degradation of sertraline and citalopram: The solutions were saturated with N 2 O, aerated and saturated with Ar (to remove air before irradiation) and irradiated in the presence of tert-butanol addition. The commonly used way of ensuring the predominance of • OH radicals in irradiated solutions is their saturation with N 2 O, which is a result of the following reaction (2).…”

Section: G =mentioning

confidence: 99%

“…95% of their unchanged form, from where they end up in sewage treatment plants [1]. A group of pharmaceuticals whose increase in consumption has particularly increased in recent years are drugs used to treat depressive disorders, which is due especially to the increasing lifestyle in highly developed countries [2] and, for example, the need for isolation caused by the COVID-19 pandemic [3]. It is estimated that globally about 350 million people suffer from depressive disorders, which is an essential cause of handicaps and suicides [4].…”

Section: Introductionmentioning

confidence: 99%

Degradation of Selected Antidepressants Sertraline and Citalopram in Ultrapure Water and Surface Water Using Gamma Radiation

et al. 2021

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Gamma radiation was applied to degradation selected antidepressants in ultrapure water and surface water. Additionally, the influence of typical radical scavengers like carbonate, nitrate and humic acid was determined. The cytotoxicity towards liver cells HepG2 and colon cells Caco2 were measured during the radiation process. It was found that radiation technology, specifically ionizing radiation, can achieve satisfactory degradation efficiency with both SER and CIT. It was shown that the process of decomposition of the tested antidepressants with the highest efficiency occurs in the reaction with the hydroxyl radical.

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“…Psychotropic medications, including antidepressants, anxiolytics, hypnotics, mood stabilisers and antipsychotics, are frequently prescribed for people experiencing mental health problems, with notable increases in prescribing rates observed year on year 1,2 . Globally, the total consumption of psychotropic medication has increased by 4% annually, with the greatest increase observed in antidepressant use 3 . This surge in the use of psychotropic medication has contributed to the ongoing debate surrounding the over-prescribing of these medications and the potentially inappropriate treatment of mental health disorders.…”

Section: Introductionmentioning

confidence: 99%

Mobile phone applications to support psychotropic tapering: a scoping review protocol

et al. 2022

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Background: In the context of a recovery-oriented approach to mental healthcare, the role of psychotropic medication over extended or indefinite periods is increasingly being called into question. To minimise the risks of withdrawal symptoms and relapse, it is crucial that service users who want to discontinue psychotropic medication are supported throughout the tapering process. However, in the absence of effective interventions and supports, service users are increasingly relying on online resources for guidance and support. To date, the evidence base for mobile phone applications (‘apps’) and app-based interventions supporting discontinuation of psychotropic use has not been examined. This scoping review aims to examine the content, underpinning evidence base and impact of available mobile phone apps and app-based interventions to support psychotropic tapering. Methods: A scoping review will be conducted using the Joanna Briggs Institute guidance and results will be reported using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for Scoping Reviews (PRISMA-ScR) guideline. Several electronic databases (MEDLINE, EMBASE, CINAHL, PsycINFO, Web of Science, ACM and IEEE Xplore) will be searched from 2008 onwards. Searches of the major app stores will also be conducted, specifically Apple's App Store (iOS) and Google Play Store (Android). Following screening, key information will be extracted from the included studies and apps. Identified apps will be coded using the Behaviour Change Technique (BCT) Taxonomy. The findings will be described using narrative synthesis. Conclusions: This scoping review will provide a broad overview of available apps to support psychotropic tapering, including a summary of their content using the BCT Taxonomy. The review findings will guide future research relating to the development, implementation and evaluation of app-based interventions to support the tapering of psychotropic medication.

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Psychotropic medicine consumption in 65 countries and regions, 2008–19: a longitudinal study

Cited by 69 publications

References 35 publications

Impact of COVID-19 Pandemic on the Use of Antidepressant and Antianxiety Pharmaceuticals as Well as Sick Leave in Poland

Impact of COVID-19 Pandemic on the Use of Antidepressant and Antianxiety Pharmaceuticals as Well as Sick Leave in Poland

Degradation of Selected Antidepressants Sertraline and Citalopram in Ultrapure Water and Surface Water Using Gamma Radiation

Mobile phone applications to support psychotropic tapering: a scoping review protocol

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