Psychotropic Drugs in Pregnancy and Lactation

Goldberg, Harold L.; Nissim, Robyn

doi:10.2190/2bf1-0718-we7f-a9f7

Cited by 62 publications

(25 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with several new "atypical" antipsychotics, clozapine is unique in its effectiveness. Although pharmacological properties and side effects of clozapine are widely known, little is known about the safety profile of clozapine in pregnancy and labour (Goldberg and Nissim, 1994). In this report, we present cases of two pregnant women receiving clozapine treatment.…”

Section: Introductionmentioning

confidence: 93%

Case Report: Clozapine use in two women with schizophrenia during pregnancy

Duran¹,

Uğur²,

Turan³

et al. 2007

J Psychopharmacol

View full text Add to dashboard Cite

Stabilized patients who receive clozapine may wish to have children; but studies on pregnant women receiving clozapine treatment are limited. In this study, we report on clozapine use during pregnancy in two women. The first woman (Case 1) had two deliveries while she was receiving clozapine treatment for schizophrenia. Both her deliveries were term, uncomplicated vaginal deliveries, and the clozapine dose was reduced throughout pregnancy. The second woman (Case 2) developed schizophrenia after her first child was born. She became pregnant after clozapine initiation. She delivered twins by term, uncomplicated vaginal delivery. In our cases, no specific risks for the mothers and their children can be attributed to the use of clozapine. Physicians must be aware of the changes in fertility induced by prolactin-sparing drugs. Mothers who receive clozapine treatment should not be advised to breastfeed their children.

show abstract

Section: Introductionmentioning

confidence: 93%

Case Report: Clozapine use in two women with schizophrenia during pregnancy

Duran¹,

Uğur²,

Turan³

et al. 2007

J Psychopharmacol

View full text Add to dashboard Cite

show abstract

“…FLU could potentially bind to DA and NE reuptake sites at 10 mg/kg, so the highest dose in this study (8 mg/kg) was chosen to avoid these effects. FLU has a half-life (including its metabolites) of approximately 8-15 h in rats (Raap and Van de Kar, 1999), has been successfully administered to pregnant rats (Montero et al, 1990), and has been used by women throughout gestation (Goldberg and Nissim, 1994).…”

Section: Treatmentmentioning

confidence: 99%

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

Johns

Joyner

McMurray

et al. 2005

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Studies using dopaminergic and serotonergic agonists or antagonists implicate involvement of these systems in various aspects of early maternal behavior and postpartum aggression towards an intruder in rats, both of which are associated with the presence of oxytocin in specific brain regions. It is unclear however, if or how long-term uptake inhibition of either neurotransmitter system alone or in combination, affects oxytocin system dynamics or maternal behavior/ aggression. Pregnant women frequently take drugs (antidepressants, cocaine) that induce longterm reuptake inhibition of dopamine and/or serotonin, thus it is important to understand these effects on behavior and biochemistry. Rat dams were treated throughout gestation with amfonelic acid, fluoxetine, or a combination of both, to investigate effects of reuptake inhibition of dopamine and serotonin systems respectively, on maternal behavior, aggression and oxytocin. The more appetitive aspects of maternal behavior (nesting, licking, touching) and activity were increased by the low dose of amfonelic acid, high dose of fluoxetine, or the high dose combination more than other treatments. Aggression was decreased by amfonelic acid and somewhat increased by fluoxetine. Dopamine uptake inhibition appears to have a strong effect on hippocampal oxytocin levels, while receptor dynamics may be more strongly affected by serotonin uptake inhibition.

show abstract

“…Recent studies have shown no increase in the incidence of spontaneous abortions or malformations with the use of amitriptyline or imipramine (Goldberg 1994). However, there is limited information on the safety of other TCAs such as doxepin, dothiepin, lofepramine and clomipramine (McElhatton 1999).…”

Section: Tricyclic Antidepressants (Tcas)mentioning

confidence: 99%

A comparative study of pregnant women attending a tertiary obstetric unit and a district general hospital with a previous history of postnatal depression

Conlon

Price

2006

Journal of Obstetrics and Gynaecology

View full text Add to dashboard Cite

The aim of this study was to compare pregnant women with a previous history of postnatal depression, attending a Tertiary Obstetric Unit in Belfast and a District General Hospital in Newry. Women with a previous history of postnatal depression recorded at booking for their most current pregnancy were studied between January 2001 and May 2002. A total of 443 women (6.6%) in Belfast had a history of postnatal depression, compared with 113 women (6%) in Newry. The most common age range was 31 - 35 years in both centres. Some 69% of women in Belfast compared with 81% of women in Newry were given treatment. Fluoxetine was the commonly prescribed drug for each centre. During this subsequent pregnancy, 19 women (4.3%) in Belfast and five women (4.4%) in Newry remained on antidepressants. There was one woman in each centre who took an overdose during this pregnancy. More women in Newry were given treatment. During the subsequent pregnancy, the percentages of women from each unit requiring antidepressant therapy were similar.

show abstract

Psychotropic Drugs in Pregnancy and Lactation

Abstract: Though no controlled studies have ever been done in pregnant women to truly prove their safety, it appears that most, but not all, current psychotropic drugs appear fairly safe for use in pregnancy.

Cited by 62 publications

References 53 publications

Case Report: Clozapine use in two women with schizophrenia during pregnancy

Case Report: Clozapine use in two women with schizophrenia during pregnancy

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

A comparative study of pregnant women attending a tertiary obstetric unit and a district general hospital with a previous history of postnatal depression

Contact Info

Product

Resources

About